{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:53:36Z","timestamp":1788630816150,"version":"build-2803163510"},"reference-count":9,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T00:00:00Z","timestamp":1363219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>An article by Sasidharan et al. recently published in the journal Molecules [1] claimed to show the hepatoprotective effects of lantadene A against acetaminophen-induced liver damage in mice. While reading this paper, I came across certain points that need to be clarified and taken up in the interest of science and other scientists working in this area.<\/jats:p>","DOI":"10.3390\/molecules18033442","type":"journal-article","created":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T12:22:04Z","timestamp":1363263724000},"page":"3442-3444","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Remarks on Sasidharan et al. \u201cEvaluation of the Hepatoprotective Effects of Lantadene A, a Pentacyclic Triterpenoid of Lantana Plants against Acetaminophen-induced Liver Damage\u201d. Molecules 2012, 17, 13937-13947"],"prefix":"10.3390","volume":"18","author":[{"given":"Manu","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Jaypee University of Information Technology, Waknaghat-173234, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2013,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"13937","DOI":"10.3390\/molecules171213937","article-title":"Evaluation of the Hepatoprotective Effects of Lantadene A, a Pentacyclic Triterpenoid of Lantana Plants against Acetaminophen-induced Liver Damage","volume":"17","author":"Chen","year":"2012","journal-title":"Molecules"},{"key":"ref_2","unstructured":"ToxNet Toxicology Data Network, Lantadene, Available online:http:\/\/toxnet.nlm.nih.gov\/cgi-bin\/sis\/search\/a?dbs+hsdb:@term+@DOCNO+3503."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/jbt.2570060108","article-title":"Molecular structure, polymorphism, and toxicity of lantadene A, the pentacyclic triterpenoid from the hepatotoxic plant Lantana camara","volume":"6","author":"Sharma","year":"1991","journal-title":"J. Biochem. Toxicol."},{"key":"ref_4","unstructured":"National Research Council (2010). Guide for Care and Use of Laboratory Animals, National Academy Press."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0041-0101(99)00204-4","article-title":"Biotransformation of lantadenes, the pentacyclic triterpenoid hepatotoxins of lantana plant, in guinea pig","volume":"38","author":"Sharma","year":"2000","journal-title":"Toxicon"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1751-0813.1977.tb00195.x","article-title":"The oral toxicity for sheep of triterpene acids isolated from Lantana camara","volume":"53","author":"Seawright","year":"1977","journal-title":"Aust. Vet. J."},{"key":"ref_7","first-page":"10","article-title":"Toxicity of isolated Lantana (Lantana camara L) constituents to male and female guinea pigs","volume":"31","author":"Sharma","year":"1989","journal-title":"Vet. Hum. Toxicol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/10408440601177863","article-title":"A review of the hepatotoxic plant Lantana camara","volume":"37","author":"Sharma","year":"2007","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/MCG.0b013e31818a3854","article-title":"Acetaminophen hepatotoxicity and acute liver failure","volume":"43","author":"Chun","year":"2009","journal-title":"J. Clin. Gastroenterol."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/18\/3\/3442\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:45:32Z","timestamp":1760219132000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/18\/3\/3442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,14]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3]]}},"alternative-id":["molecules18033442"],"URL":"https:\/\/doi.org\/10.3390\/molecules18033442","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,14]]}}}