{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:21:37Z","timestamp":1772792497706,"version":"3.50.1"},"reference-count":69,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Three diorganotin(IV) complexes of the general formula R2Sn[RcC(O)N(RN)O] (Rc = aryl, RN = Alkyl) have been synthesized by refluxing in toluene the corresponding diorganotin(IV) oxides with the free ligand N-methyl p-fluorobenzohydroxamic acid, using a Dean and Stark water separator. The ligand was derived from the reaction of the corresponding p-fluorobenzoyl chloride and N-methylhydroxylamine hydrochloride in the presence of sodium hydrogen carbonate. The isolated free ligand and its respective diorganotin compounds have been characterized by elemental analysis, IR and 1H-, 13C-, 119Sn-NMR spectroscopies. The crystal structures of the diorganotin complexes have been confirmed by single crystal X-ray diffraction methods. The investigations carried out on the diorganotin(IV) complexes of N-methyl p-fluorobenzohydroxamic acid confirmed a 1:2 stoichiometry. The complex formation took place through the O,O-coordination via the carbonyl oxygen and subsequent deprotonated hydroxyl group to the tin atom. The crystal structures of three diorganotin complexes were determined and were found to adopt six coordination geometries at the tin centre with coordination to two ligand moieties.<\/jats:p>","DOI":"10.3390\/molecules18078696","type":"journal-article","created":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T13:28:05Z","timestamp":1374586085000},"page":"8696-8711","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Diorganotin(IV) Derivatives of N-Methyl p-Fluorobenzo-Hydroxamic Acid: Preparation, Spectral Characterization,  X-ray Diffraction Studies and Antitumor Activity"],"prefix":"10.3390","volume":"18","author":[{"family":"Naqeebullah","sequence":"first","affiliation":[{"name":"School of Chemical Sciences and Food Technology, Faculty of Science & Technology,  Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor Darul Ehsan, Malaysia"},{"name":"Department of Chemistry, Faculty of Basic Sciences, University of Balochistan,  87300 Sariab Road Quetta, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Farina","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences and Food Technology, Faculty of Science & Technology,  Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor Darul Ehsan, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kok","family":"Chan","sequence":"additional","affiliation":[{"name":"Environmental Health Programme, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lo","family":"Mun","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nor","family":"Rajab","sequence":"additional","affiliation":[{"name":"Biomedical Science Programme, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theng","family":"Ooi","sequence":"additional","affiliation":[{"name":"Biomedical Science Programme, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2013,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7121","DOI":"10.1016\/j.tetlet.2011.10.103","article-title":"A convenient procedure for the solid-phase synthesis of hydroxamic acids on PEGA resins","volume":"52","author":"Nandurkar","year":"2011","journal-title":"Tetrahedron Lett."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S0039-9140(02)00135-2","article-title":"Dihydroxamate based siderophore model, piperazine-1,4-bis-(N-methyl-acetohydroxamic acid (PIPDMAHA), as a chelating agent of molybdenum(VI)","volume":"57","author":"Farkas","year":"2002","journal-title":"Talanta"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1016\/j.bmcl.2003.07.020","article-title":"\u03b1-Substituted hydroxamic acids as novel bacterial deformylase inhibitor-based antibacterial agents","volume":"13","author":"Jain","year":"2003","journal-title":"Bioorg. 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