{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:30:22Z","timestamp":1787614222503,"version":"build-2736575974"},"reference-count":58,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T00:00:00Z","timestamp":1378166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Honokiol is a bioactive component isolated from the medicinal herbs Magnolia officinalis and Magnolia grandiflora that has antioxidative, anti-inflammatory, antithrombotic, and antitumor activities. The inhibitory potentials of honokiol on eight major human cytochrome P450 (CYP) enzymes 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, and 3A4, and four UDP-glucuronosyltransferases (UGTs) 1A1, 1A4, 1A9, and 2B7 in human liver microsomes were investigated using liquid chromatography-tandem mass spectrometry. Honokiol strongly inhibited CYP1A2-mediated phenacetin O-deethylation, CYP2C8-mediated amodiaquine N-deethylation, CYP2C9-mediated diclofenac 4-hydroxylation, CYP2C19-mediated [S]-mephenytoin 4-hydroxylation, and UGT1A9-mediated propofol glucuronidation with Ki values of 1.2, 4.9, 0.54, 0.57, and 0.3 \u03bcM, respectively. Honokiol also moderately inhibited CYP2B6-mediated bupropion hydroxylation and CYP2D6-mediated bufuralol 1'-hydroxylation with Ki values of 17.5 and 12.0 \u03bcM, respectively. These in vitro results indicate that honokiol has the potential to cause pharmacokinetic drug interactions with other co-administered drugs metabolized by CYP1A2, CYP2C8, CYP2C9, CYP2C19, and UGT1A9.<\/jats:p>","DOI":"10.3390\/molecules180910681","type":"journal-article","created":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T12:43:48Z","timestamp":1378212228000},"page":"10681-10693","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Effect of Honokiol on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes"],"prefix":"10.3390","volume":"18","author":[{"given":"Hyeon-Uk","family":"Jeong","sequence":"first","affiliation":[{"name":"College of Pharmacy, the Catholic University of Korea, Bucheon 420-743, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae","family":"Kong","sequence":"additional","affiliation":[{"name":"College of Pharmacy, the Catholic University of Korea, Bucheon 420-743, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon","family":"Kwon","sequence":"additional","affiliation":[{"name":"College of Pharmacy, the Catholic University of Korea, Bucheon 420-743, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Woon","family":"Hong","sequence":"additional","affiliation":[{"name":"Huons Co., Ltd., Ansan 426-791, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung","family":"Yeon","sequence":"additional","affiliation":[{"name":"Huons Co., Ltd., Ansan 426-791, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Huons Co., Ltd., Ansan 426-791, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae","family":"Lee","sequence":"additional","affiliation":[{"name":"Huons Co., Ltd., Ansan 426-791, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Cho","sequence":"additional","affiliation":[{"name":"College of Pharmacy, the Catholic University of Korea, Bucheon 420-743, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1055-9628","authenticated-orcid":false,"given":"Hye","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy, the Catholic University of Korea, Bucheon 420-743, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2013,9,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.phymed.2007.03.005","article-title":"Protective action of honokiol, administered orally, against oxidative stress in brain of mice challenged with NMDA","volume":"14","author":"Cui","year":"2007","journal-title":"Phytomedicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.bcp.2008.06.012","article-title":"Honokiol is a potent scavenger of superoxide and peroxyl radicals","volume":"76","author":"Dikalov","year":"2008","journal-title":"Biochem. 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