{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T01:24:51Z","timestamp":1780536291036,"version":"3.54.1"},"reference-count":25,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T00:00:00Z","timestamp":1379030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Peperomia pellucida is a plant used in traditional medicine to treat gastric ulcers. Although this gastroprotective activity was reported, the active compounds have not been identified. Therefore, the aim herein was to identify the most active compound in the gastroprotective activity of P. pellucida using an ethanol-induced gastric ulcer experimental rat model. A gastroprotective effect was observed when the hexane and dichloromethane extracts were tested, with the higher effect being obtained with the dichloromethane extract (82.3 \u00b1 5.6%) at 100 mg\/kg. Dillapiole was identified as the most active compound in this extract. Although there have been previous reports on dillapiole, this is the first on its gastroprotective activity. Rats treated with this compound at 3, 10, 30 and 100 mg\/kg showed 23.1, 56.1, 73.2 and 85.5% gastroprotection, respectively. The effect elicited by dillapiole at 100 mg\/kg was not attenuated by pretreatment with indomethacin (10 mg\/kg, s.c.), a prostaglandin synthesis blocker, NG-nitro-l-arginine methyl ester (70 mg\/kg, i.p.), a nitric oxide (NO) synthase inhibitor, or N-ethylmaleimide (10 mg\/kg, s.c.), a blocker of sulfhydryl groups. This suggests that the gastroprotective mechanism of action of dillapiole does not involve prostaglandins, NO or sulfhydryl groups.<\/jats:p>","DOI":"10.3390\/molecules180911327","type":"journal-article","created":{"date-parts":[[2013,9,16]],"date-time":"2013-09-16T11:14:40Z","timestamp":1379330080000},"page":"11327-11337","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Dillapiole, Isolated from Peperomia pellucida,  Shows Gastroprotector Activity against Ethanol-Induced Gastric Lesions in Wistar Rats"],"prefix":"10.3390","volume":"18","author":[{"given":"Ra\u00fal","family":"Rojas-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n, Colonia Santo Tom\u00e1s, Delegaci\u00f3n Miguel Hidalgo, M\u00e9xico D.F., 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Arrieta","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n, Colonia Santo Tom\u00e1s, Delegaci\u00f3n Miguel Hidalgo, M\u00e9xico D.F., 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Cruz-Antonio","sequence":"additional","affiliation":[{"name":"Facultad de Estudios Superiores Zaragoza, UNAM, Batalla del 5 de Mayo Esquina Fuerte de Loreto, Ej\u00e9rcito de Oriente, M\u00e9xico D.F., 09230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9466-1907","authenticated-orcid":false,"given":"Daniel","family":"Arrieta-Baez","sequence":"additional","affiliation":[{"name":"Centro de Nanociencias y Micro y Nanotecnolog\u00edas del Instituto Polit\u00e9cnico Nacional,  Unidad Profesional Adolfo L\u00f3pez Mateos, Luis Enrique Erro S\/N, Zacatenco, M\u00e9xico D.F., 07738, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Vel\u00e1zquez-M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Universidad Tecnol\u00f3gica de la Selva, Entronque Tonin\u00e1 Carretera Ocosingo-Altamirano, Ocosingo, Estado de Chiapas, 29950, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"S\u00e1nchez-Mendoza","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n, Colonia Santo Tom\u00e1s, Delegaci\u00f3n Miguel Hidalgo, M\u00e9xico D.F., 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2013,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1515\/znc-2007-7-812","article-title":"Nerolidol, an antiulcer constituent from the essential oil of Baccharis dracunculifolia DC (Asteraceae)","volume":"62","author":"Klopell","year":"2007","journal-title":"Z. 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