{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:14:48Z","timestamp":1791267288552,"version":"4.1.0"},"reference-count":26,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T00:00:00Z","timestamp":1390262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Ursolic acid, an important bioactive compound, was isolated from ethanol extract of aerial parts of Sambucus australis. In order to develop bioactive ursolic acid derivatives, two semi-synthetic compounds were obtained through modification at C-3. The antibacterial activity of the ursolic acid and its derivatives was investigated. The microdilution method was used for determination of the minimal inhibitory concentration (MIC), against twelve bacterial strains. The influence of ursolic acid and its derivatives on the susceptibility of some bacterial pathogens to the aminoglycosides antibiotics neomycin, amikacin, kanamycin and gentamicin was evaluated. The most representative synergistic effect was observed by 3\u03b2-formyloxy-urs-12-en-28-oic acid at the concentration of  64 \u03bcg\/mL in combination with kanamycin against Escherichia coli (27), a multidrug-resistant clinical isolate from sputum, with reduction of MIC value from 128 \u03bcg\/mL to  8 \u03bcg\/mL. Ursolic acid and its derivatives were examined for their radical scavenger activity using the DPPH assay, and showed significant activity.<\/jats:p>","DOI":"10.3390\/molecules19011317","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T11:55:07Z","timestamp":1390305307000},"page":"1317-1327","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":223,"title":["Antibacterial and Antioxidant Activities of Ursolic Acid  and Derivatives"],"prefix":"10.3390","volume":"19","author":[{"given":"Patr\u00edcia","family":"Do Nascimento","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica e Inorg\u00e2nica, Universidade Federal do Cear\u00e1,  Fortaleza-CE 60451-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Telma","family":"Lemos","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica e Inorg\u00e2nica, Universidade Federal do Cear\u00e1,  Fortaleza-CE 60451-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayla","family":"Bizerra","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica e Inorg\u00e2nica, Universidade Federal do Cear\u00e1,  Fortaleza-CE 60451-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c2ngela","family":"Arriaga","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica e Inorg\u00e2nica, Universidade Federal do Cear\u00e1,  Fortaleza-CE 60451-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica e Inorg\u00e2nica, Universidade Federal do Cear\u00e1,  Fortaleza-CE 60451-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilvandete","family":"Santiago","sequence":"additional","affiliation":[{"name":"Departamento de Farm\u00e1cia, Universidade Federal do Cear\u00e1, Fortaleza-CE 60430-370, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimundo","family":"Braz-Filho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Ci\u00eancias Qu\u00edmicas (LCQUI)-CCT-UENF\/PPGQO-DEQUIM-UFRRJ,  Campos dos Goytacazes-RJ 28013-602, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Costa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa de Produtos Naturais, Universidade Regional do Cariri,  Crato-CE 63105-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1021\/np200060p","article-title":"Uncoupling and antioxidant effects of ursolic acid in isolated rat heart mitochondria","volume":"74","author":"Liobikas","year":"2011","journal-title":"J. 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