{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T17:51:12Z","timestamp":1775238672054,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Eleven new 2,6-di-tert-butyl-4-(5-aryl-1,3,4-oxadiazol-2-yl)phenols 5a\u2013k were synthesized by reacting aryl hydrazides with 3,5-di-tert butyl 4-hydroxybenzoic acid in the presence of phosphorus oxychloride. The resulting compounds were characterized based on their IR, 1H-NMR, 13C-NMR, and HRMS data. 2,2-Diphenyl-1-picrylhydrazide (DPPH) and ferric reducing antioxidant power (FRAP) assays were used to test the antioxidant properties of the compounds. Compounds 5f and 5j exhibited significant free-radical scavenging ability in both assays.<\/jats:p>","DOI":"10.3390\/molecules19033436","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T12:06:02Z","timestamp":1395317162000},"page":"3436-3449","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Synthesis of New 2,5-Di-substituted 1,3,4-Oxadiazoles Bearing 2,6-Di-tert-butylphenol Moieties and Evaluation of Their Antioxidant Activity"],"prefix":"10.3390","volume":"19","author":[{"given":"Raied","family":"Shakir","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia"},{"name":"Department of Chemistry, Ibn Al-haitham, University of Baghdad, Baghdad 61023, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azhar","family":"Ariffin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmood","family":"Abdulla","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Faculty of Medicine, University of Malaya,  Kuala Lumpur 50603, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2014,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.resp.2010.08.019","article-title":"Redox-control of matrix metalloproteinase-1: A critical link between free radicals, matrix remodeling and degenerative disease","volume":"174","author":"Kar","year":"2010","journal-title":"Respir. 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