{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T01:31:35Z","timestamp":1789349495958,"version":"build-2803163510"},"reference-count":28,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T00:00:00Z","timestamp":1395619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The study of medicinal plants for treatment of periodontitis is of great value to establish their efficacy as sources of new antimicrobial drugs. Five hundred and fifty eight Korean local plant extracts were screened for antibacterial activity against representative periodontopathic bacteria such as Porphyromonas gingivalis, Prevotella intermedia, and Fusobacterium nucleatum. Among the various medicinal plants, the alcohol extract of Pittosporum tobira, which significantly exhibited antibacterial effect for all tested strains, showed the highest activity in the antimicrobial assays. NMR analyses revealed that  R1-barrigenol, a triterpene sapogenin, was the most effective compound in P. tobira. These results demonstrated that P. tobira possesses antimicrobial properties and would be beneficial for the prevention and treatment of periodontitis.<\/jats:p>","DOI":"10.3390\/molecules19033607","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T13:43:41Z","timestamp":1395668621000},"page":"3607-3616","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound"],"prefix":"10.3390","volume":"19","author":[{"given":"Jung-Hyun","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University, Kyunghee Daero 26, Dongdaemungu, Seoul 130-701, Korea"},{"name":"Institute of Oral Biology, Kyung Hee University, Kyunghee Daero 26, Dongdaemungu,  Seoul 130-701, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Life Science, Gachon University, Seongnam Daero 1342, Seongnam,  Gyeonggi-Do 461-701, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Life Science, Gachon University, Seongnam Daero 1342, Seongnam,  Gyeonggi-Do 461-701, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Life Science, Gachon University, Seongnam Daero 1342, Seongnam,  Gyeonggi-Do 461-701, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Life Science, Gachon University, Seongnam Daero 1342, Seongnam,  Gyeonggi-Do 461-701, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoang","family":"Khoa","sequence":"additional","affiliation":[{"name":"Department of Biological & Environmental Science, Dongguk University, Pildongro-1gil 30, Junggu, Seoul 100-715, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Biological & Environmental Science, Dongguk University, Pildongro-1gil 30, Junggu, Seoul 100-715, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Biological & Environmental Science, Dongguk University, Pildongro-1gil 30, Junggu, Seoul 100-715, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University, Kyunghee Daero 26, Dongdaemungu, Seoul 130-701, Korea"},{"name":"Institute of Oral Biology, Kyung Hee University, Kyunghee Daero 26, Dongdaemungu,  Seoul 130-701, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,3,24]]},"reference":[{"key":"ref_1","first-page":"74","article-title":"Profiles of periodontal conditions in adults measured by CPITN","volume":"41","author":"Miyazaki","year":"1991","journal-title":"Int. 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