{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:06:53Z","timestamp":1780668413415,"version":"3.54.1"},"reference-count":43,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T00:00:00Z","timestamp":1395619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Schistosomiasis is a neglected tropical disease that affects hundreds of millions of people worldwide. Since the treatment of this disease currently relies on a single drug, praziquantel, new and safe schistosomicidal agents are urgently required. Nerolidol, a sesquiterpene present in the essential oils of several plants, is found in many foods and was approved by the U.S. Food and Drug Administration. In this study we analysed the in vitro antiparasitic effect of nerolidol on Schistosoma mansoni adult worms. Nerolidol at concentrations of 31.2 and 62.5 \u03bcM reduced the worm motor activity and caused the death of all male and female schistosomes, respectively. In addition, confocal laser scanning microscopy revealed morphological alterations on the tegument of worms such as disintegration, sloughing and erosion of the surface, and a correlation between viability and tegumental damage was observed. In conclusion, nerolidol may be a promising lead compound for the development of antischistosomal natural agents.<\/jats:p>","DOI":"10.3390\/molecules19033793","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T13:43:41Z","timestamp":1395668621000},"page":"3793-3803","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Antischistosomal Activity of the Terpene Nerolidol"],"prefix":"10.3390","volume":"19","author":[{"given":"Marcos","family":"Silva","sequence":"first","affiliation":[{"name":"Faculdade de Ci\u00eancias de Guarulhos (FACIG\/UNIESP), Av. Guarulhos, 1844,  Guarulhos, SP 07025-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade Federal do Piau\u00ed,  Teresina, PI 64049-550, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rusbene","family":"De Carvalho","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Biotecnologia, Universidade Federal do Piau\u00ed,  Teresina, PI 64049-550, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7180-4896","authenticated-orcid":false,"given":"Dami\u00e3o","family":"De Sousa","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Farmac\u00eauticas, Universidade Federal da Para\u00edba,  Jo\u00e3o Pessoa, PB 58051-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rivelilson","family":"Freitas","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade Federal do Piau\u00ed,  Teresina, PI 64049-550, Brazil"},{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Biotecnologia, Universidade Federal do Piau\u00ed,  Teresina, PI 64049-550, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Pinto","sequence":"additional","affiliation":[{"name":"Enteroparasitas, Instituto Adolfo Lutz, S\u00e3o Paulo, SP 01246-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josu\u00e9","family":"Moraes","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias de Guarulhos (FACIG\/UNIESP), Av. 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