{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:52:43Z","timestamp":1790808763660,"version":"4.1.0"},"reference-count":103,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T00:00:00Z","timestamp":1400803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Ministry of Education, University and Research, Italy","award":["RBFR-0895DC"],"award-info":[{"award-number":["RBFR-0895DC"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Neurodegenerative disorders, such as Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD) and frontotemporal dementias (FTD), are considered distinct entities, however, there is increasing evidence of an overlap from the clinical, pathological and genetic points of view. All neurodegenerative diseases are characterized by neuronal loss and death in specific areas of the brain, for example, hippocampus and cortex for AD, midbrain for PD, frontal and temporal lobes for FTD. Loss of neurons is a relatively late event in the progression of neurodegenerative diseases that is typically preceded by other events such as metabolic changes, synaptic dysfunction and loss, neurite retraction, and the appearance of other abnormalities, such as axonal transport defects. The brain\u2019s ability to compensate for these dysfunctions occurs over a long period of time and results in late clinical manifestation of symptoms, when successful pharmacological intervention is no longer feasible. Currently, diagnosis of AD, PD and different forms of dementia is based primarily on analysis of the patient\u2019s cognitive function. It is therefore important to find non-invasive diagnostic methods useful to detect neurodegenerative diseases during early, preferably asymptomatic stages, when a pharmacological intervention is still possible. Altered expression of microRNAs (miRNAs) in many disease states, including neurodegeneration, and increasing relevance of miRNAs in biofluids in different pathologies has prompted the study of their possible application as neurodegenerative diseases biomarkers in order to identify new therapeutic targets. Here, we review what is known about the role of miRNAs in the pathogenesis of neurodegeneration and the possibilities and challenges of using these small RNA molecules as a signature for neurodegenerative conditions.<\/jats:p>","DOI":"10.3390\/molecules19056891","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T12:46:27Z","timestamp":1400849187000},"page":"6891-6910","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":187,"title":["Circulating miRNAs as Biomarkers for  Neurodegenerative Disorders"],"prefix":"10.3390","volume":"19","author":[{"given":"Margherita","family":"Grasso","sequence":"first","affiliation":[{"name":"Laboratory of RNA Biology and Biotechnology, Centre for Integrative Biology,  University of Trento, via Sommarive 9, 38123 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Piscopo","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Confaloni","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Denti","sequence":"additional","affiliation":[{"name":"Laboratory of RNA Biology and Biotechnology, Centre for Integrative Biology,  University of Trento, via Sommarive 9, 38123 Trento, Italy"},{"name":"Neuroscience Institute, National Research Council (CNR), Padova 35100, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,5,23]]},"reference":[{"key":"ref_1","unstructured":"miRBase Sequence Database. 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