{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:06:30Z","timestamp":1791111990345,"version":"4.1.0"},"reference-count":68,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T00:00:00Z","timestamp":1404950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Plumbagin is a plant naphtoquinone exerting anti-cancer properties including apoptotic cell death induction and generation of reactive oxygen species (ROS). The aim of this study was to elucidate parameters explaining the differential leukemia cell sensitivity towards this compound. Among several leukemia cell lines, U937 monocytic leukemia cells appeared more sensitive to plumbagin treatment in terms of cytotoxicity and level of apoptotic cell death compared to more resistant Raji Burkitt lymphoma cells. Moreover, U937 cells exhibited a ten-fold higher ROS production compared to Raji. Neither differential incorporation, nor efflux of plumbagin was detected. Pre-treatment with thiol-containing antioxidants prevented ROS production and subsequent induction of cell death by apoptosis whereas non-thiol-containing antioxidants remained ineffective in both cellular models. We conclude that the anticancer potential of plumbagin is driven by pro-oxidant activities related to the cellular thiolstat.<\/jats:p>","DOI":"10.3390\/molecules190710011","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T11:22:59Z","timestamp":1404991379000},"page":"10011-10032","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Plumbagin Modulates Leukemia Cell Redox Status"],"prefix":"10.3390","volume":"19","author":[{"given":"Fran\u00e7ois","family":"Gaascht","sequence":"first","affiliation":[{"name":"Laboratoire de Biologie Mol\u00e9culaire et Cellulaire du Cancer (LBMCC), H\u00f4pital Kirchberg, 9, Rue Edward Steichen, L-2540 Luxembourg, Grand-Duchy of Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Teiten","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Mol\u00e9culaire et Cellulaire du Cancer (LBMCC), H\u00f4pital Kirchberg, 9, Rue Edward Steichen, L-2540 Luxembourg, Grand-Duchy of Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9308-8176","authenticated-orcid":false,"given":"Claudia","family":"Cerella","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Mol\u00e9culaire et Cellulaire du Cancer (LBMCC), H\u00f4pital Kirchberg, 9, Rue Edward Steichen, L-2540 Luxembourg, Grand-Duchy of Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Dicato","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Mol\u00e9culaire et Cellulaire du Cancer (LBMCC), H\u00f4pital Kirchberg, 9, Rue Edward Steichen, L-2540 Luxembourg, Grand-Duchy of Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denyse","family":"Bagrel","sequence":"additional","affiliation":[{"name":"Laboratoire Structure et R\u00e9activit\u00e9 des Syst\u00e8mes Mol\u00e9culaires Complexes, UMR CNRS 7565, Universit\u00e9 de Lorraine, Campus Bridoux, Rue du G\u00e9n\u00e9ral Delestraint, F-57070 Metz, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0115-4725","authenticated-orcid":false,"given":"Marc","family":"Diederich","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 151-742, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.2217\/epi.11.73","article-title":"Epigenomics of leukemia: From mechanisms to therapeutic applications","volume":"3","author":"Florean","year":"2011","journal-title":"Epigenomics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.bcp.2012.02.004","article-title":"Micrornas in cancer management and their modulation by dietary agents","volume":"83","author":"Karius","year":"2012","journal-title":"Biochem. 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