{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:45:22Z","timestamp":1790819122227,"version":"4.1.0"},"reference-count":37,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T00:00:00Z","timestamp":1404259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this work we investigated the in vivo protective effects of Baccharis dracunculifolia leaves extract (BdE) against carbon tetrachloride (CCl4)- and acetaminophen (APAP)-induced hepatotoxicity. Total phenolic content, total flavonoid content, antioxidant DPPH radical scavenging activity, and HPLC analysis were performed. Our results showed that pretreatment with BdE significantly reduced the damage caused by CCl4 and APAP on the serum markers of hepatic injury, AST, ALT, and ALP. Results were confirmed by histopathological analysis. Phytochemical analysis, performed by HPLC, showed that BdE was rich in p-coumaric acid derivatives, caffeoylquinic acids and flavonoids. BdE also showed DPPH antioxidant activity (EC50 of 15.75 \u00b1 0.43 \u03bcg\/mL), and high total phenolic (142.90 \u00b1 0.77 mg GAE\/g) and flavonoid (51.47 \u00b1 0.60 mg RE\/g) contents. This study indicated that B. dracunculifolia leaves extract has relevant in vivo hepatoprotective properties.<\/jats:p>","DOI":"10.3390\/molecules19079257","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T04:14:27Z","timestamp":1404360867000},"page":"9257-9272","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Protective Effects of Baccharis dracunculifolia Leaves Extract against Carbon Tetrachloride- and Acetaminophen-Induced Hepatotoxicity in Experimental Animals"],"prefix":"10.3390","volume":"19","author":[{"given":"T\u00falio","family":"Rezende","sequence":"first","affiliation":[{"name":"Identifica\u00e7\u00e3o e Pesquisa em Princ\u00edpios Ativos  Naturais - NIPPAN, Faculdade de Farm\u00e1cia, Universidade Federal de Juiz de Fora, Rua Jos\u00e9 Louren\u00e7o Kelmer, s\/n \u2013 Campus Universit\u00e1rio, Bairro S\u00e3o Pedro, CEP36036-900, Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Corr\u00eaa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Bioatividade Celular e Molecular, Universidade Federal de Juiz de Fora, Rua Jos\u00e9 Louren\u00e7o Kelmer, s\/n \u2013 Campus Universit\u00e1rio, Bairro S\u00e3o Pedro, CEP36036-900, Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Aarestrup","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia e Patologia Experimental, Universidade Federal de Juiz de Fora, Rua Jos\u00e9 Louren\u00e7o Kelmer, s\/n \u2013 Campus Universit\u00e1rio, Bairro S\u00e3o Pedro, CEP36036-900, Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Aarestrup","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia e Patologia Experimental, Universidade Federal de Juiz de Fora, Rua Jos\u00e9 Louren\u00e7o Kelmer, s\/n \u2013 Campus Universit\u00e1rio, Bairro S\u00e3o Pedro, CEP36036-900, Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orlando","family":"De Sousa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacologia de Produtos Naturais, Universidade Federal de Juiz de Fora, Rua Jos\u00e9 Louren\u00e7o Kelmer, s\/n \u2013 Campus Universit\u00e1rio, Bairro S\u00e3o Pedro, CEP36036-900, Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ademar","family":"Da Silva Filho","sequence":"additional","affiliation":[{"name":"Identifica\u00e7\u00e3o e Pesquisa em Princ\u00edpios Ativos  Naturais - NIPPAN, Faculdade de Farm\u00e1cia, Universidade Federal de Juiz de Fora, Rua Jos\u00e9 Louren\u00e7o Kelmer, s\/n \u2013 Campus Universit\u00e1rio, Bairro S\u00e3o Pedro, CEP36036-900, Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,7,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.foodchem.2011.09.026","article-title":"Antioxidant and hepatoprotective activity of ethanolic extract of leaves of Solidago microglossa containing polyphenolic compounds","volume":"131","author":"Sabir","year":"2012","journal-title":"Food Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.fct.2011.11.014","article-title":"Baccharis dracunculifolia, the main source of green propolis, exhibits potent antioxidant activity and prevents oxidative mitochondrial damage","volume":"50","author":"Mello","year":"2012","journal-title":"Food Chem. 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