{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:06:30Z","timestamp":1789589190354,"version":"build-2803163510"},"reference-count":30,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T00:00:00Z","timestamp":1404864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Inorganic UV filters have become attractive because of their role in protecting the skin from the damage caused by continuous exposure to the sun. However, their large refractive index and high photocatalytic activity have led to the development of alternative inorganic materials such as CePO4 for application as UV filters. This compound leaves a  low amount of white residue on the skin and is highly stable. The aim of this study was to evaluate the physical and chemical stability of a cosmetic formulation containing ordinary organic UV filters combined with 5% CePO4, and, to compare it with other formulations containing the same vehicle with 5% TiO2 or ZnO as inorganic materials. The rheological behavior and chemical stability of the formulations containing these different UV filters were investigated. Results showed that the formulation containing CePO4 is a promising innovative UV filter due to its low interaction with organic filters, which culminates in longer shelf life when compared with traditional formulations containing ZnO or TiO2 filters. Moreover, the recognized ability of CePO4 to leave a low amount of white residue on the skin combined with great stability, suggests that CePO4 can be used as inorganic filter in high concentrations, affording formulations with high SPF values.<\/jats:p>","DOI":"10.3390\/molecules19079907","type":"journal-article","created":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T11:18:18Z","timestamp":1404904698000},"page":"9907-9925","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Stability of Sunscreens Containing CePO4: Proposal for a New Inorganic UV Filter"],"prefix":"10.3390","volume":"19","author":[{"given":"Vitor","family":"Seixas","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Philosophy, Sciences and Languages of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, SP 14040-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo","family":"Serra","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Philosophy, Sciences and Languages of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, SP 14040-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,7,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000109085","article-title":"Transdermal Penetration of UV Filters","volume":"21","author":"Klinubol","year":"2008","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jchromb.2003.12.022","article-title":"Liquid chromatographic assay for common sunscreen agents: Application to in vivo assessment of skin penetration and systemic absorption in human volunteers","volume":"803","author":"Sarveiya","year":"2004","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1046\/j.1365-2125.1999.00056.x","article-title":"Absorption of sunscreens across human skin: An evaluation of commercial products for children and adults","volume":"4","author":"Jiang","year":"1999","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000098701","article-title":"human skin penetration of sunscreen nanoparticles: In-vitro assessment of a novel micronized zinc oxide formulation","volume":"20","author":"Cross","year":"2007","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_5","unstructured":"Lowe, N.J., Shaath, N.A., and Pathak, M.A. (1997). Sunscreens: Development, Evaluation and Regulatory Aspects, Dekker. [1st ed.]."},{"key":"ref_6","unstructured":"Bahia, M.F. (2003). Prote\u00e7\u00e3o Solar Actualiza\u00e7\u00e3o, Editora Universidade do Porto. [1\u00aa ed.]. (In portugueses)."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1046\/j.1365-2133.1997.17761863.x","article-title":"The influence of sunscreen type on photoprotection","volume":"137","author":"Diffey","year":"1997","journal-title":"Br. J. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"9006","DOI":"10.1016\/j.apsusc.2009.06.071","article-title":"ZnO:CeO2-based nanopowders with low catalytic activity as UV bsorbers","volume":"255","author":"Lima","year":"2009","journal-title":"Appl. Surf. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.26850\/1678-4618eqj.v30.1.2005.p59-64","article-title":"Synthesis, structural and morphological characterization of CeO2\u2014ZnO nanosized powder systems from Pechini\u2019s method","volume":"30","author":"Peverari","year":"2005","journal-title":"Eclet. Qu\u00edm."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.dyepig.2012.12.020","article-title":"Cerium phosphate nanoparticles with low photocatalytic activity for UV light absorption application in photoprotection","volume":"97","author":"Lima","year":"2013","journal-title":"Dyes Pigment."},{"key":"ref_11","unstructured":"Lima, J.F., Neri, C.R., and Serra, O.A. (2008). Processo de Obten\u00e7\u00e3o de Nanopart\u00edculas de Fosfato de c\u00e9rio e Formula\u00e7\u00f5es Contendo o. (PI0801782\u20134 A2), Mesmo. Patent, (In portugueses)."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1016\/j.jssc.2006.06.013","article-title":"UV absorption properties of ceria-modified compositions within the fluorite-type solid solution CeO2\u2013Y6WO12","volume":"179","author":"Chevire","year":"2006","journal-title":"J. Solid State Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.3390\/molecules17022219","article-title":"Benefits of combinations of vitamin A, C and E derivatives in the stability of cosmetic formulations","volume":"17","author":"Gianeti","year":"2012","journal-title":"Molecules"},{"key":"ref_14","unstructured":"Costa, A. (2012). Tratado Internacional de Cosmec\u00eauticos, Guanabara Koogan. (In portugueses)."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ijpharm.2006.07.015","article-title":"Stability of cosmetics formulations containing vitamins E and A esters: Chemical and physical aspects","volume":"11","author":"Guaratini","year":"2006","journal-title":"Int. J. Pharm."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.1208\/ps050107","article-title":"Rheology and stability of water-in-oil-in-water multiple emulsions containing Span 83 and Tween 80","volume":"5","author":"Jiao","year":"2003","journal-title":"AAPS Pharm. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/jcla.20016","article-title":"Determining shelf life by comparing degradations temperatures","volume":"18","author":"Magari","year":"2004","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1081\/DIS-200066829","article-title":"Physicochemical characterization of canola oil water nanoemulsions obtained by determination of required HLB number and emulsion phase inversion methods","volume":"27","author":"Morais","year":"2006","journal-title":"J. Dispers. Sci. Technol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0927-7757(00)00796-2","article-title":"Effects of amine oxide compounds on the zeta potencial of emulsion droplets by phosphatidylcoline","volume":"181","author":"Jeong","year":"2001","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0378-5173(03)00364-8","article-title":"Systematic characteriztion of oil-in-watr emulsion for formulation design","volume":"263","author":"Roland","year":"2003","journal-title":"Int. J. Pharm."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.3390\/molecules14082684","article-title":"Physical carboxymethylscleroglucan\/calcium ion hydrogels as modified drug delivery systems in topical formulations","volume":"14","author":"Corrente","year":"2009","journal-title":"Molecules"},{"key":"ref_22","unstructured":"Brummer, R. (2006). Rheology Essentials of Cosmetic and Food Emulsions, Springer Verlarg. [1st ed.]."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.colsurfa.2008.05.019","article-title":"Effects of polymeric dispersants on the rheology and UV-protecting properties of complex suspensions of titanium dioxides and zinc oxides","volume":"326","author":"Nasu","year":"2008","journal-title":"Coll. Surf. A"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0378-5173(02)00462-3","article-title":"Rheological behavior and the SPF of sunscreens","volume":"250","author":"Gaspar","year":"2003","journal-title":"Int. J. Pharm."},{"key":"ref_25","first-page":"70","article-title":"Formulation of sunscreens with enhancement sun protection factor response based on solid lipid nanoparticles","volume":"33","author":"Nesseem","year":"2011","journal-title":"Int. J. Pharm."},{"key":"ref_26","unstructured":"Swarbrick, J., and Boylan, J.C. (1992). Encyclopedia of Pharmaceutical Technology, Marcel Dekker Inc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jphotobiol.2010.09.002","article-title":"UV-shielding property, photocatalytic activity and photocytotoxicity of ceria colloid solutions","volume":"102","author":"Zholobak","year":"2011","journal-title":"J. Photoch. Photobiol. B: Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0254-0584(02)00027-5","article-title":"UV shielding properties of zinc oxide-doped ceria fine powders derived via soft solution chemical routes","volume":"75","author":"Li","year":"2002","journal-title":"Mater. Chem. Phys."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.ica.2005.12.057","article-title":"Inorganic and organic UV filters: Their role and efficacy in sunscreens and suncare products","volume":"360","author":"Serpone","year":"2007","journal-title":"Inorg. Chim. Acta"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jphotobiol.2004.12.006","article-title":"Reactive oxygen species produced upon photoexcitation of sunscreens containing titanium dioxide (an EPR study)","volume":"79","author":"Brezov","year":"2005","journal-title":"J. Photochem. Photobiol. B: Biol."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/19\/7\/9907\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:13:28Z","timestamp":1760217208000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/19\/7\/9907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,9]]},"references-count":30,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,7]]}},"alternative-id":["molecules19079907"],"URL":"https:\/\/doi.org\/10.3390\/molecules19079907","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,9]]}}}