{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:16:55Z","timestamp":1791501415085,"version":"4.3.4"},"reference-count":254,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T00:00:00Z","timestamp":1407283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["CPRR13091742482"],"award-info":[{"award-number":["CPRR13091742482"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Most anti-cancer drugs are derived from natural resources such as marine, microbial and botanical sources. Cutaneous malignant melanoma is the most aggressive form of skin cancer, with a high mortality rate. Various treatments for malignant melanoma are available, but due to the development of multi-drug resistance, current or emerging chemotherapies have a relatively low success rates. This emphasizes the importance of discovering new compounds that are both safe and effective against melanoma. In vitro testing of melanoma cell lines and murine melanoma models offers the opportunity for identifying mechanisms of action of plant derived compounds and extracts. Common  anti-melanoma effects of natural compounds include potentiating apoptosis, inhibiting cell proliferation and inhibiting metastasis. There are different mechanisms and pathways responsible for anti-melanoma actions of medicinal compounds such as promotion of caspase activity, inhibition of angiogenesis and inhibition of the effects of tumor promoting proteins such as PI3-K, Bcl-2, STAT3 and MMPs. This review thus aims at providing an overview of anti-cancer compounds, derived from natural sources, that are currently used in cancer chemotherapies, or that have been reported to show anti-melanoma, or anti-skin cancer activities. Phytochemicals that are discussed in this review include flavonoids, carotenoids, terpenoids, vitamins, sulforaphane, some polyphenols and crude plant extracts.<\/jats:p>","DOI":"10.3390\/molecules190811679","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T11:04:13Z","timestamp":1407323053000},"page":"11679-11721","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":240,"title":["Review of Natural Compounds for Potential Skin  Cancer Treatment"],"prefix":"10.3390","volume":"19","author":[{"given":"Tawona","family":"Chinembiri","sequence":"first","affiliation":[{"name":"Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0954-2976","authenticated-orcid":false,"given":"Lissinda","family":"Du Plessis","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minja","family":"Gerber","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8916-3927","authenticated-orcid":false,"given":"Josias","family":"Hamman","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0474-9409","authenticated-orcid":false,"given":"Jeanetta","family":"Du Plessis","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.24095\/hpcdp.33.2.03","article-title":"Cancer incidence, mortality and survival trends in Canada, 1970\u20132007","volume":"33","author":"Kachuri","year":"2013","journal-title":"Chronic Dis. Inj. Can."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.imlet.2005.06.008","article-title":"Role of apoptosis in basal cell and squamous cell carcinoma formation","volume":"100","author":"Erb","year":"2005","journal-title":"Immunol. Lett."},{"key":"ref_3","unstructured":"Reed, J.C., and Green, D.R. (2011). Apoptosis: Physiology and Pathology, Cambridge University Press."},{"key":"ref_4","first-page":"305","article-title":"Non-melanoma skin cancer","volume":"Volume 10","author":"Hall","year":"2010","journal-title":"Sauer\u2019s Manual of Skin Diseases"},{"key":"ref_5","first-page":"191","article-title":"Cancer and age","volume":"Volume 1","author":"Birren","year":"2007","journal-title":"Encyclopedia of Gerontology"},{"key":"ref_6","unstructured":"Eckman, M., Labus, D., and Thompson, G. (2010). Atlas of Pathophysiology, Wolters Kluwer Health. [3rd ed.]."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2147\/CCID.S3507","article-title":"Management of superficial basal cell carcinoma: Focus on imiquimod","volume":"2","author":"Raasch","year":"2009","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_8","unstructured":"Sweetman, S.C. (2011). Martindale: The Complete Drug Reference, Pharmaceutical Press. [37th ed.]."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1016\/j.addr.2013.07.012","article-title":"Role of integrated cancer nanomedicine in overcoming drug resistance","volume":"65","author":"Iyer","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1016\/j.addr.2013.09.018","article-title":"Multidrug resistance: Physiological principles and nanomedical solutions","volume":"65","author":"Kunjachan","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.addr.2013.09.019","article-title":"Nanomedicine therapeutic approaches to overcome cancer drug resistance","volume":"65","author":"Markman","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1093\/qjmed\/hcr129","article-title":"The experiences of cancer patients","volume":"104","author":"Alifrangis","year":"2011","journal-title":"QJM"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1136\/bmj.300.6737.1458","article-title":"Attitudes to chemotherapy: Comparing views of patients with cancer with those of doctors, nurses, and general public","volume":"300","author":"Slevin","year":"1990","journal-title":"Brit. Med. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"68","DOI":"10.12968\/ijpn.2011.17.2.68","article-title":"Hard choices: A qualitative study of influences on the treatment decisions made by advanced lung cancer patients","volume":"17","author":"Thornton","year":"2011","journal-title":"Int. Palliat. Nurs."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/annonc\/mdi110","article-title":"Use of complementary and alternative medicine in cancer patients: A European survey","volume":"16","author":"Molassiotis","year":"2005","journal-title":"Ann. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1016\/j.bbagen.2013.02.008","article-title":"Natural products: A continuing source of novel drug leads","volume":"1830","author":"Cragg","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_17","unstructured":"Heinrich, M.B.J., Gibbons, S., and Williamson, E.M. (2004). Fundamentals of Pharmacognosy and Phytotherapy, Churchill Livingstone. [1st ed.]."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.3390\/md11124876","article-title":"Anticancer and cancer preventive properties of marine polysaccharides: Some results and prospects","volume":"11","author":"Fedorov","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_19","first-page":"119","article-title":"Discovery and development of anticancer agents from marine sponges: Perspectives based on a chemistry-experimental therapeutics collaborative program","volume":"10","author":"Valeriote","year":"2012","journal-title":"Exp. Ther. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3390\/md12010098","article-title":"Exploring bioactive properties of marine cyanobacteria isolated from the Portuguese coast: High potential as a source of anticancer compounds","volume":"12","author":"Costa","year":"2014","journal-title":"Mar. Drugs"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/jphp.12097","article-title":"Finding chemo: The search for marine-based pharmaceutical drugs active against cancer","volume":"65","author":"Indumathy","year":"2013","journal-title":"Pharm. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3390\/md12010255","article-title":"Marine-sourced anti-cancer and cancer pain control agents in clinical and late preclinical development","volume":"12","author":"Newman","year":"2014","journal-title":"Mar. Drugs"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S1470-2045(00)00292-8","article-title":"Marine organisms as a source of new anticancer drugs","volume":"2","author":"Schwartsmann","year":"2001","journal-title":"Lancet. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/postgradmedj\/79.938.672","article-title":"Dr William Coley and tumour regression: A place in history or in the future","volume":"79","author":"Cann","year":"2003","journal-title":"Postgrad. Med."},{"key":"ref_25","first-page":"9","article-title":"Natural sources as potential anti-cancer agents: A review","volume":"3","author":"Bhanot","year":"2011","journal-title":"Int. Phytomed."},{"key":"ref_26","unstructured":"Van Wyk, B., van Oudtshoorn, B., and Gericke, N. (1997). Medicinal Plants of South Africa, Briza Publications. [1st ed.]."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jep.2005.05.011","article-title":"Plants as a source of anti-cancer agents","volume":"100","author":"Cragg","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.lfs.2005.09.012","article-title":"Drug discovery from medicinal plants","volume":"78","author":"Balunas","year":"2005","journal-title":"Life Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.phrs.2009.01.017","article-title":"Natural compounds for cancer treatment and prevention","volume":"59","author":"Nobili","year":"2009","journal-title":"Pharmacol. Res."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Mansky, P.J., Wallerstedt, D.B., Sannes, T.S., Stagl, J., Johnson, L.L., Blackman, M.R., Grem, J.L., Swain, S.M., and Monahan, B.P. (2013). NCCAM\/NCI phase 1 study of mistletoe extract and gemcitabine in patients with advanced solid tumors. Evid. Based Complement. Alternat. Med., 2013.","DOI":"10.1155\/2013\/964592"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/cncr.27719","article-title":"Phase 2 trial of daily, oral polyphenon E in patients with asymptomatic, Rai stage 0 to II chronic lymphocytic leukemia","volume":"119","author":"Shanafelt","year":"2013","journal-title":"Cancer"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.phymed.2013.09.002","article-title":"Berberine in combination with doxorubicin suppresses growth of murine melanoma B16F10 cells in culture and xenograft","volume":"21","author":"Mittal","year":"2014","journal-title":"Phytomedicine"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1016\/j.fct.2012.07.014","article-title":"Lignan constituents of Tilia amurensis and their biological evaluation on antitumor and anti-inflammatory activities","volume":"50","author":"Kim","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.taap.2013.09.021","article-title":"Green tea polyphenol, (\u2212)-epigallocatechin-3-gallate, induces toxicity in human skin cancer cells by targeting \u03b2-catenin signaling","volume":"273","author":"Singh","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.bbagen.2012.04.013","article-title":"Apigenin induces apoptosis via tumor necrosis factor receptor- and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fluorouracil and cisplatin","volume":"1820","author":"Chan","year":"2012","journal-title":"Biochim. Biophys. Acta Gen. S."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ijc.20785","article-title":"Anti-proliferative and proapoptotic effects of (\u2212)-epigallocatechin-3-gallate on human melanoma: Possible implications for the chemoprevention of melanoma","volume":"114","author":"Nihal","year":"2005","journal-title":"Int. J. Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.abb.2010.11.015","article-title":"Green tea prevents non-melanoma skin cancer by enhancing DNA repair","volume":"508","author":"Katiyar","year":"2011","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1016\/j.foodres.2011.05.021","article-title":"Can phytochemical antioxidant rich foods act as anticancer agents?","volume":"44","author":"Wang","year":"2011","journal-title":"Food Res. Int."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.taap.2013.05.004","article-title":"Antioxidants: Friends or foe in prevention or treatment of cancer: The debate of the century","volume":"271","author":"Saeidnia","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s13205-013-0117-5","article-title":"Anti-cancer potential of flavonoids: Recent trends and future perspectives","volume":"3","author":"Batra","year":"2013","journal-title":"3 Biotech"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3109\/13880209.2011.559476","article-title":"Inhibition of tumor progression by naturally occurring terpenoids","volume":"49","author":"Kuttan","year":"2011","journal-title":"Pharm. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/BF00054304","article-title":"Vegetables, fruit, and cance. II. Mechanisms","volume":"2","author":"Steinmetz","year":"1991","journal-title":"Cancer Causes Control"},{"key":"ref_43","unstructured":"Hendrickson, J.B. (1965). The Molecules of Nature: A Survey of The Biosynthesis And Chemistry of Natural Products, W.A. Benjamin, Inc."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1080\/21551197.2012.698219","article-title":"Flavonoid basics: Chemistry, sources, mechanisms of action, and safety","volume":"31","author":"Corcoran","year":"2012","journal-title":"J. Nutr. Gerontol. Geriatr."},{"key":"ref_45","first-page":"1394","article-title":"Pharmacological Activities of Flavonoids: A Review","volume":"4","author":"Agrawal","year":"2011","journal-title":"Int. J. Pharm. Sci. Nanotech."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0031-9422(00)00235-1","article-title":"Advances in flavonoid research since 1992","volume":"55","author":"Harborne","year":"2000","journal-title":"Phytochemistry"},{"key":"ref_47","first-page":"129","article-title":"Photoprotection of natural flavonoids","volume":"3","author":"Saewan","year":"2013","journal-title":"J. Appl. Pharm. Sci."},{"key":"ref_48","first-page":"172","article-title":"Quercetin","volume":"16","author":"Kelly","year":"2011","journal-title":"Altern. Med. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1111\/j.1349-7006.2011.02035.x","article-title":"Effects of dietary flavonoids, luteolin, and quercetin on the reversal of epithelial-mesenchymal transition in A431 epidermal cancer cells","volume":"102","author":"Lin","year":"2011","journal-title":"Cancer Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"439","DOI":"10.4162\/nrp.2013.7.6.439","article-title":"Anticarcinogenic effect of quercetin by inhibition of insulin-like growth factor (IGF)-1 signaling in mouse skin cancer","volume":"7","author":"Jung","year":"2013","journal-title":"Nutr. Res. Pract."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bbadis.2012.10.010","article-title":"FTIR spectroscopy: A new valuable tool to classify the effects of polyphenolic compounds on cancer cells","volume":"1832","author":"Derenne","year":"2013","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/01635581.2014.864418","article-title":"Site-specific anticancer effects of dietary flavonoid quercetin","volume":"66","author":"Sak","year":"2014","journal-title":"Nutr. Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.nutres.2004.07.005","article-title":"Review of the flavonoids quercetin, hesperetin, and naringenin: Dietary sources, bioactivities, bioavailability, and epidemiology","volume":"24","author":"Erlund","year":"2004","journal-title":"Nutr. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0304-3835(97)04644-2","article-title":"Bioavailability of the dietary antioxidant flavonol quercetin in man","volume":"114","author":"Hollman","year":"1997","journal-title":"Cancer Lett."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3109\/10408363.2011.631268","article-title":"Natural polyphenols in cancer therapy","volume":"48","author":"Asensi","year":"2011","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/1097-0215(20000815)87:4<595::AID-IJC21>3.0.CO;2-5","article-title":"Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential","volume":"87","author":"Caltagirone","year":"2000","journal-title":"Int. J. Cancer"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1271\/bbb.60129","article-title":"Late type apoptosis and apoptosis free lethal effect of quercetin in human melanoma","volume":"70","author":"Rosner","year":"2006","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00280-004-0863-5","article-title":"Apoptosis of murine melanoma B16-BL6 cells induced by quercetin targeting mitochondria, inhibiting expression of PKC-\u03b1 and translocating PKC-\u03b4","volume":"55","author":"Zhang","year":"2005","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1158\/1940-6207.CAPR-09-0220","article-title":"Quercetin potentiates UVB-Induced c-Fos expression: Implications for its use as a chemopreventive agent","volume":"3","author":"Olson","year":"2010","journal-title":"Cancer Prev. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.taap.2013.03.015","article-title":"Quercitin protects skin from UVB-induced oxidative damage","volume":"269","author":"Yin","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.bcp.2013.11.008","article-title":"Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling","volume":"87","author":"Cao","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jphotobiol.2006.01.006","article-title":"Protective effect of topical formulations containing quercetin against UVB-induced oxidative stress in hairless mice","volume":"84","author":"Casagrande","year":"2006","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.ejps.2012.04.024","article-title":"Anti-inflammatory activity and percutaneous absorption of quercetin and its polymethoxylated compound and glycosides: The relationships to chemical structures","volume":"47","author":"Lin","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"601","DOI":"10.3923\/pjbs.2013.601.609","article-title":"Biocompatible nanoparticles for sustained topical delivery of anticancer phytoconstituent quercetin","volume":"16","author":"Sneha","year":"2013","journal-title":"Pak. J. Biol. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.3109\/03639045.2011.641564","article-title":"Permeation and skin retention of quercetin from microemulsions containing Transcutol\u00ae P","volume":"38","author":"Censi","year":"2012","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.jff.2013.04.002","article-title":"Antioxidative phenolic constituents of skins of onion varieties and their activities","volume":"5","author":"Albishi","year":"2013","journal-title":"J. Funct. Foods"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1016\/j.foodchem.2012.11.139","article-title":"Review: A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention","volume":"138","author":"Allen","year":"2013","journal-title":"Food Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1021\/jf000892m","article-title":"Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants","volume":"49","author":"Miean","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"298","DOI":"10.2174\/138955711795305335","article-title":"A review on the dietary flavonoid kaempferol","volume":"11","year":"2011","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/S0006-2952(01)00583-4","article-title":"Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: Regulation of cyclin-dependent kinases CDK2 and CDK1","volume":"61","author":"Casagrande","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1248\/cpb.c12-00372","article-title":"The effect of submicron emulsion systems on transdermal delivery of kaempferol","volume":"60","author":"Chao","year":"2012","journal-title":"Chem. Pharm. Bull."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.jiec.2011.11.126","article-title":"In vitro skin permeation and cellular protective effects of flavonoids isolated from Suaeda asparagoides extracts","volume":"18","author":"Park","year":"2011","journal-title":"J. Ind. Eng. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1038\/srep03169","article-title":"Antioxidant induces DNA damage, cell death and mutagenicity in human lung and skin normal cells","volume":"3","author":"Lu","year":"2013","journal-title":"Sci. Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2174\/1568013053005454","article-title":"Dietary phytochemicals in chemoprevention of cancer","volume":"5","author":"Russo","year":"2005","journal-title":"Curr. Med. Chem. Immunol. Endocr. Metab. Agents"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1207\/S15327914NC382_16","article-title":"Induction of apoptosis and cell cycle arrest in cancer cells by in vivo metabolites of teas","volume":"38","author":"Zhang","year":"2000","journal-title":"Nutr. Cancer"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s11095-010-0054-5","article-title":"Anti-melanoma effects of vorinostat in combination with polyphenolic antioxidant (\u2212)-epigallocatechin-3-gallate (EGCG)","volume":"27","author":"Nihal","year":"2010","journal-title":"Pharm. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.4161\/cc.8.13.8862","article-title":"(\u2212)-Epigallocatechin-3-gallate (EGCG) sensitizes melanoma cells to interferon induced growth inhibition in a mouse model of human melanoma","volume":"8","author":"Nihal","year":"2009","journal-title":"Cell Cycle"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.phrs.2011.03.001","article-title":"Review: Cancer prevention by tea: Evidence from laboratory studies","volume":"64","author":"Chung","year":"2011","journal-title":"Pharm. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1207\/S15327914nc392_20","article-title":"Differential responses of skin cancer-chemopreventive agents silibinin, quercetin, and epigallocatechin 3-gallate on mitogenic signaling and cell cycle regulators in human epidermoid carcinoma A431 cells","volume":"39","author":"Bhatia","year":"2001","journal-title":"Nutr. Cancer"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/carcin\/bgq285","article-title":"(\u2212)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1\/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells","volume":"32","author":"Nandakumar","year":"2011","journal-title":"Carcinogenesis"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1468-3083.2006.02045.x","article-title":"Effects of polyphenols on skin damage due to ultraviolet A rays: An experimental study on rats","volume":"21","author":"Senen","year":"2007","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Watson, R.R., and Preedy, V.R. (2010). Bioactive Foods in Promoting Health: Fruits and Vegetables, Elsevier.","DOI":"10.1201\/b10330"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1007\/s11095-010-0089-7","article-title":"Apigenin: A promising molecule for cancer prevention","volume":"27","author":"Shukla","year":"2010","journal-title":"Pharm. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jams.2013.07.002","article-title":"Research article: Apigenin, a bioactive flavonoid from lycopodium lavatum, stimulates nucleotide excision repair genes to protect skin keratinocytes from ultraviolet B-induced reactive oxygen species and DNA damage","volume":"6","author":"Das","year":"2013","journal-title":"J. Acupunct. Meridian Stud."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/carcin\/bgs358","article-title":"Src kinase is a direct target of apigenin against UVB-induced skin inflammation","volume":"34","author":"Byun","year":"2013","journal-title":"Carcinogenesis"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ijpharm.2013.11.017","article-title":"Pharmaceutical nanotechnology: Enhanced in vitro and in vivo skin deposition of apigenin delivered using ethosomes","volume":"460","author":"Qin","year":"2014","journal-title":"Int. J. Pharm."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.toxlet.2013.09.012","article-title":"Strategic formulation of apigenin-loaded PLGA nanoparticles for intracellular trafficking, DNA targeting and improved therapeutic effects in skin melanoma in vitro","volume":"223","author":"Das","year":"2013","journal-title":"Toxicol. Lett."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.fct.2013.09.037","article-title":"Efficacy of PLGA-loaded apigenin nanoparticles in Benzo[a]pyrene and ultraviolet-B induced skin cancer of mice: Mitochondria mediated apoptotic signalling cascades","volume":"62","author":"Das","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ijpharm.2008.08.002","article-title":"In vitro and in vivo evaluation of topical delivery and potential dermal use of soy isoflavones genistein and daidzein","volume":"364","author":"Huang","year":"2008","journal-title":"Int. J. Pharm."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1600-0781.2008.00329.x","article-title":"Topical isoflavones provide effective photoprotection to skin","volume":"24","author":"Lin","year":"2008","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Iovine, B., Iannella, M.L., Gasparri, F., Monfrecola, G., and Bevilacqua, M.A. (2011). Synergic effect of genistein and daidzein on UVB-induced DNA damage: An effective photoprotective combination. J. Biomed. Biotechnol.","DOI":"10.1155\/2011\/692846"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0955-2863(02)00184-5","article-title":"Effects of genistein and daidzein on the cell growth, cell cycle, and differentiation of human and murine melanoma cells","volume":"13","author":"Wang","year":"2002","journal-title":"J. Nutr. Biochem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/01635580903191585","article-title":"Natural phenolic compounds from medicinal herbs and dietary plants: Potential use for cancer prevention","volume":"62","author":"Huang","year":"2010","journal-title":"Nutr. Cancer"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1016\/j.bmcl.2006.01.117","article-title":"Synthesis of phospholipase A2 inhibitory biflavonoids","volume":"16","author":"Chen","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jep.2013.03.079","article-title":"Effect of a Garcinia gardneriana (Planchon and Triana) Zappi hydroalcoholic extract on melanogenesis in B16F10 melanoma cells","volume":"148","author":"Campos","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1080\/08923970802278276","article-title":"Amentoflavone inhibits experimental tumor metastasis through a regulatory mechanism involving MMP-2, MMP-9, prolyl hydroxylase, lysyl oxidase, VEGF, ERK-1, ERK-2, STAT-1, NM23 and cytokines in lung tissues of C57BL\/6 mice","volume":"30","author":"Guruvayoorappan","year":"2008","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"19641","DOI":"10.1074\/jbc.M110.186239","article-title":"The biflavonoid amentoflavone inhibits neovascularization preventing the activity of proangiogenic vascular endothelial growth factors","volume":"286","author":"Tarallo","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/1534735407302345","article-title":"Effect of amentoflavone on the inhibition of pulmonary metastasis induced by B16F-10 melanoma cells in C57BL\/6 mice","volume":"6","author":"Guruvayoorappan","year":"2007","journal-title":"Integr. Cancer Ther."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jmgm.2013.12.008","article-title":"Discovery of potent inhibitor for matrix metalloproteinase-9 by pharmacophore based modeling and dynamics simulation studies","volume":"49","author":"Kalva","year":"2014","journal-title":"J. Mol. Graphics Modell."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.mam.2005.10.001","article-title":"Carotenoid actions and their relation to health and disease","volume":"26","author":"Krinsky","year":"2005","journal-title":"Mol. Aspects. Med."},{"key":"ref_101","unstructured":"Rodriguez-Amaya, D.B. (2001). A Guide to Carotenoid Analysis in Foods, ILSI Press."},{"key":"ref_102","first-page":"725","article-title":"An international evaluation of the cancer preventive potential of carotenoids","volume":"7","author":"Vainio","year":"1998","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bbadis.2004.12.006","article-title":"Bioactivity and protective effects of natural carotenoids","volume":"1740","author":"Stahl","year":"2005","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.3390\/molecules17033202","article-title":"Cancer chemoprevention by carotenoids","volume":"17","author":"Tanaka","year":"2012","journal-title":"Molecules"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.clindermatol.2010.03.033","article-title":"Nutrition and nonmelanoma skin cancers","volume":"28","author":"Payette","year":"2010","journal-title":"Clin. Dermatol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1207\/S15327914nc392_21","article-title":"\u03b2-carotene uptake and bioconversion to retinol differ between human melanocytes and keratinocytes","volume":"39","author":"Andersson","year":"2001","journal-title":"Nutr. Cancer"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1207\/s15327914nc4701_10","article-title":"mechanism of activation of caspase cascade during \u03b2-carotene-induced apoptosis in human tumor cells","volume":"47","author":"Palozza","year":"2003","journal-title":"Nutr. Cancer"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.nutres.2007.04.009","article-title":"\u03b2-Carotene down-regulates inducible nitric oxide synthase gene expression and induces apoptosis by suppressing bcl-2 expression and activating caspase-3 and p53 genes in B16F-10 melanoma cells","volume":"27","author":"Guruvayoorappan","year":"2007","journal-title":"Nutr. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1177\/1534735407305978","article-title":"Beta-carotene inhibits tumor-specific angiogenesis by altering the cytokine profile and inhibits the nuclear translocation of transcription factors in B16F-10 melanoma cells","volume":"6","author":"Guruvayoorappan","year":"2007","journal-title":"Integr. Cancer Ther."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1207\/s15327914nc5102_13","article-title":"The microarray expression analysis identifies BAX as a mediator of \u03b2-carotene effects on apoptosis","volume":"51","author":"Bodzioch","year":"2005","journal-title":"Nutr. Cancer"},{"key":"ref_111","first-page":"1143","article-title":"Dietary factors in the prevention and treatment of non-melanoma skin cancer and melanoma","volume":"28","author":"Bialy","year":"2002","journal-title":"Dermatol. Surg."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1158\/1055-9965.1042.13.6","article-title":"Diet and melanoma in a case-control study","volume":"13","author":"Millen","year":"2004","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/1534735406298897","article-title":"Disease regression in malignant melanoma: Spontaneous resolution or a result of treatment with antioxidants, green tea, and pineapple cores? A case report","volume":"6","author":"Michael","year":"2007","journal-title":"Integr. Cancer Ther."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1093\/jn\/137.9.2098","article-title":"Antioxidant supplementation increases the risk of skin cancers in women but not in men","volume":"137","author":"Hercberg","year":"2007","journal-title":"J. Nutr."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1016\/j.ejca.2010.06.008","article-title":"Incidence of skin cancers during 5-year follow-up after stopping antioxidant vitamins and mineral supplementation","volume":"46","author":"Ezzedine","year":"2010","journal-title":"Eur. J. Cancer"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1056\/NEJM199605023341801","article-title":"Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease","volume":"334","author":"Hennekens","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"ref_117","first-page":"837","article-title":"Serological precursors of cancer: Malignant melanoma, basal and squamous cell skin cancer, and prediagnostic levels of retinol, beta- carotene, lycopene, alpha-tocopherol, and selenium","volume":"4","author":"Breslow","year":"1995","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"260S","DOI":"10.1093\/ajcn\/53.1.260S","article-title":"Prediagnostic serum levels of carotenoids and vitamin E as related to subsequent cancer in Washington County, Maryland","volume":"53","author":"Comstock","year":"1991","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.lfs.2007.09.018","article-title":"Lycopene inhibits PDGF-BB-induced signaling and migration in human dermal fibroblasts through interaction with PDGF-BB","volume":"81","author":"Chiang","year":"2007","journal-title":"Life Sci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1042\/BST0351377","article-title":"Inhibitory effect of lycopene on PDGF-BB-induced signalling and migration in human dermal fibroblasts: A possible target for cancer","volume":"35","author":"Wu","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"604","DOI":"10.3390\/md10030604","article-title":"Fucoxantin: A treasure from the sea","volume":"10","author":"Gemello","year":"2012","journal-title":"Mar. Drugs"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1007\/s10126-013-9507-2","article-title":"Isolation of fucoxanthin and highly unsaturated monogalactosyldiacylglycerol from brown alga Fucus evanescens C Agardh and in vitro investigation of their antitumor activity","volume":"15","author":"Imbs","year":"2013","journal-title":"Mar. Biotechnol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"5130","DOI":"10.3390\/md11125130","article-title":"Fucoxanthin: A marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms","volume":"11","author":"Kumar","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.etap.2012.10.002","article-title":"Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells","volume":"35","author":"Kim","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.bbrc.2013.09.019","article-title":"Marine algal fucoxanthin inhibits the metastatic potential of cancer cells","volume":"439","author":"Chung","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1111\/j.2042-7158.2010.01139.x","article-title":"Anti-pigmentary activity of fucoxanthin and its influence on skin mRNA expression of melanogenic molecules","volume":"62","author":"Shimoda","year":"2010","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Ju Hye, L., Kishikawa, M., Kumazoe, M., Yamada, K., and Tachibana, H. (2010). Vitamin A enhances antitumor effect of a green tea polyphenol on melanoma by upregulating the polyphenol sensing molecule 67-kDa laminin receptor. PLoS One, 5.","DOI":"10.1371\/journal.pone.0011051"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1755-148X.2010.00702.x","article-title":"Silencing and re-expression of retinoic acid receptor beta2 in human melanoma","volume":"23","author":"Fan","year":"2010","journal-title":"Pigm. Cell Melanoma Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1093\/aje\/kwj115","article-title":"Sun exposure, diet, and melanoma in Hawaii Caucasians","volume":"164","author":"Saltzman","year":"2006","journal-title":"Am. J. Epidemiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1038\/jid.2012.21","article-title":"Association of vitamin A and carotenoid intake with melanoma risk in a large prospective cohort","volume":"132","author":"Asgari","year":"2012","journal-title":"J. Invest. Dermatol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1600-0781.2011.00557.x","article-title":"Current sunscreen controversies: A critical review","volume":"27","author":"Burnett","year":"2011","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1177\/1559827612460499","article-title":"Ultraviolet radiation and the skin: An in-depth review","volume":"7","author":"Morganroth","year":"2013","journal-title":"Am. J. Lifestyle Med."},{"key":"ref_133","first-page":"173","article-title":"13 cis-Retinoic acid regulates cytokine production and inhibits angiogenesis by disrupting endothelial cell migration and tube formation","volume":"7","author":"Guruvayoorappan","year":"2008","journal-title":"J. Exp. Ther. Oncol."},{"key":"ref_134","first-page":"2194","article-title":"Characterization of the effects of different retinoids on the growth and differentiation of a human melanoma cell line and selected subclones","volume":"40","author":"Meyskens","year":"1980","journal-title":"Cancer Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ejphar.2013.04.038","article-title":"The combination of the antiestrogen endoxifen with all-trans-retinoic acid has anti-proliferative and anti-migration effects on melanoma cells without inducing significant toxicity in non-neoplasic cells","volume":"715","author":"Ribeiro","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/sj.bjc.6600882","article-title":"Dietary intakes of vitamins A, C, and E and risk of melanoma in two cohorts of women","volume":"88","author":"Feskanich","year":"2003","journal-title":"Br. J. Cancer"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s00262-003-0407-6","article-title":"L-ascorbic acid (vitamin C) induces the apoptosis of B16 murine melanoma cells via a caspase-8-independent pathway","volume":"52","author":"Kang","year":"2003","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.canlet.2007.05.009","article-title":"Reciprocal effects of ascorbate on cancer cell growth and the expression of matrix metalloproteinases and transforming growth factor-\u03b2","volume":"256","author":"Neena","year":"2007","journal-title":"Cancer Lett."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1002\/jcb.21336","article-title":"The molecular mechanisms of vitamin C on cell cycle regulation in B16F10 murine melanoma","volume":"102","author":"Hahm","year":"2007","journal-title":"J. Cell. Biochem."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/jcb.22997","article-title":"Vitamin C down-regulates VEGF production in B16F10 murine melanoma cells via the suppression of p42\/44 MAPK activation","volume":"112","author":"Kim","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/jcp.21391","article-title":"Vitamin C suppresses proliferation of the human melanoma cell SK-MEL-2 through the inhibition of cyclooxygenase-2 (COX-2) expression and the modulation of insulin-like growth factor II (IGF-II) production","volume":"216","author":"Koo","year":"2008","journal-title":"J. Cell. Physiol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.ejca.2008.10.003","article-title":"Vitamin D and skin cancer: A meta-analysis","volume":"45","author":"Gandini","year":"2009","journal-title":"Eur. J. Cancer"},{"key":"ref_143","first-page":"160","article-title":"Why vitamin D for cancer patients?","volume":"3","author":"Gandini","year":"2009","journal-title":"Ecancermedicalscience"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Tang, J.Y., Fu, T., Lau, C., Oh, D.H., Bikle, D.D., and Asgari, M.M. (2012). Vitamin D in cutaneous carcinogenesis: Part I. J. Am. Acad. Dermatol., 67.","DOI":"10.1016\/j.jaad.2012.07.022"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0035112","article-title":"Pre-diagnostic circulating vitamin D and risk of melanoma in men","volume":"7","author":"Major","year":"2012","journal-title":"PLoS One"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1038\/jid.2008.451","article-title":"A cohort study of vitamin D intake and melanoma risk","volume":"129","author":"Asgari","year":"2009","journal-title":"J. Invest. Dermatol."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Geyu, L., Hongmei, N., Qureshi, A.A., and Jiali, H. (2012). Pre-diagnostic plasma 25-hydroxyvitamin D levels and risk of non-melanoma skin cancer in women. PLoS One, 7.","DOI":"10.1371\/journal.pone.0035211"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1080\/01635581.2011.539314","article-title":"Inverse association between dietary vitamin D and risk of cutaneous melanoma in a northern Italy population","volume":"63","author":"Vinceti","year":"2011","journal-title":"Nutr. Cancer"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.humpath.2010.09.014","article-title":"Original contribution: Expression of vitamin D receptor decreases during progression of pigmented skin lesions","volume":"42","author":"Brozyna","year":"2011","journal-title":"Hum. Pathol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.ejca.2007.04.018","article-title":"Does solar exposure, as indicated by the non-melanoma skin cancers, protect from solid cancers: Vitamin D as a possible explanation","volume":"43","author":"Tuohimaa","year":"2007","journal-title":"Eur. J. Cancer"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1067\/msy.2002.119191","article-title":"Vitamin E inhibits melanoma growth in mice","volume":"131","author":"Malafa","year":"2002","journal-title":"Surgery"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1001\/jama.287.23.3116","article-title":"Vitamins for chronic disease prevention","volume":"287","author":"Fairfield","year":"2002","journal-title":"J. Am. Med. Assoc."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/01635580802567166","article-title":"Evidence of gamma-tocotrienol as an apoptosis-inducing, invasion-suppressing, and chemotherapy drug-sensitizing agent in human melanoma cells","volume":"61","author":"Chang","year":"2009","journal-title":"Nutr. Cancer"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0271-5317(97)00036-5","article-title":"Human study: Effect of vitamin E succinate on free radical formation, lipid peroxidation levels and cyclooxygenase activity in murine melanoma cells","volume":"17","author":"Ottino","year":"1997","journal-title":"Nutr. Res."},{"key":"ref_155","first-page":"550","article-title":"Effects of tocopherol (vitamin E) acid succinate on morphological alterations and growth inhibition in melanoma cells in culture","volume":"42","author":"Prasad","year":"1982","journal-title":"Cancer Res."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0952-3278(96)90052-6","article-title":"The role of adenylate cyclase, cAMP and PGE2 in the in vitro growth regulation of murine melanoma cells by vitamin E","volume":"54","author":"Ottino","year":"1996","journal-title":"Prostaglandins Leukotrienes Essent. Fatty Acids"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/BF02574523","article-title":"Inhibition of angiogenesis and promotion of melanoma dormancy by vitamin E succinate","volume":"9","author":"Malafa","year":"2002","journal-title":"Ann. Surg. Oncol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1111\/j.1468-3083.2011.04219.x","article-title":"Clinical evaluation of photoprotective effect by a topical antioxidants combination (tocopherols and tocotrienols)","volume":"26","author":"Pedrelli","year":"2012","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Burns, E.M., Tober, K.L., Riggenbach, J.A., Kusewitt, D.F., Young, G.S., and Oberyszyn, T.M. (2013). Differential effects of topical vitamin E and C E Ferulic\u00ae treatments on ultraviolet light B-induced cutaneous tumor development in Skh-1 mice. PLoS One, 8.","DOI":"10.1371\/journal.pone.0063809"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jconrel.2014.03.009","article-title":"Review: Vitamin E-based nanomedicines for anti-cancer drug delivery","volume":"182","author":"Nicolas","year":"2014","journal-title":"J. Controlled Release"},{"key":"ref_161","unstructured":"Mann, J., Davidson, R.S., Hobbs, J.B., Banthorpe, D.V., and Harbone, J.B. (1994). Natural Products: Their Chemistry and Biological Significance, Addison Wesley Longman."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1080\/01635580902898743","article-title":"Anticancer properties of Ganoderma Lucidum methanol extracts in vitro and in vivo","volume":"61","author":"Tufegdzic","year":"2009","journal-title":"Nutr. Cancer"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/j.fct.2008.01.027","article-title":"Anti-tumor effect of Coriolus versicolor methanol extract against mouse B16 melanoma cells: In vitro and in vivo study","volume":"46","author":"Harhaji","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2008-2231-21-39","article-title":"Cytotoxic activities of phytochemicals from Ferula species","volume":"21","author":"Valiahdi","year":"2013","journal-title":"Daru J. Pharm. Sci."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.taap.2012.08.035","article-title":"A novel mechanism of filaggrin induction and sunburn prevention by \u03b2-damascenone in Skh-1 mice","volume":"265","author":"Uddin","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.fct.2005.09.001","article-title":"A review of the toxicity of Melaleuca alternifolia (tea tree) oil","volume":"44","author":"Hammer","year":"2006","journal-title":"Food Chem. Toxicol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jdermsci.2012.05.005","article-title":"Topically applied Melaleuca alternifolia (tea tree) oil causes direct anti-cancer cytotoxicity in subcutaneous tumour bearing mice","volume":"67","author":"Ireland","year":"2012","journal-title":"J. Dermatol. Sci."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S1572-5995(08)80032-4","article-title":"Stilbenoids: Chemistry and bioactivities","volume":"Volume 34","author":"Rahman","year":"2008","journal-title":"Studies in Natural Products Chemistry"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Ramawat, K.G., and Merillon, J.M. (2013). Natural Products, Springer.","DOI":"10.1007\/978-3-642-22144-6"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/138945006776359331","article-title":"Resveratrol as a chemopreventive agent: A promising molecule for fighting cancer","volume":"7","author":"Delmas","year":"2006","journal-title":"Curr. Drug Targets"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0304-3835(02)00676-6","article-title":"Resveratrol is a potent inducer of apoptosis in human melanoma cells","volume":"190","author":"Niles","year":"2003","journal-title":"Cancer Lett."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/jcb.22601","article-title":"Resveratrol induces cell-cycle disruption and apoptosis in chemoresistant B16 melanoma","volume":"110","author":"Gatouillat","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1177\/1753425912436589","article-title":"Resveratrol inhibits LPS-induced epithelial-mesenchymal transition in mouse melanoma model","volume":"18","author":"Chen","year":"2012","journal-title":"Innate Immun."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jss.2013.02.037","article-title":"A potential role for resveratrol as a radiation sensitizer for melanoma treatment","volume":"183","author":"Fang","year":"2013","journal-title":"J. Surg. Res."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jss.2010.07.033","article-title":"Enhancing melanoma treatment with resveratrol","volume":"172","author":"Osmond","year":"2012","journal-title":"J. Surg. Res."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1093\/jn\/136.10.2542","article-title":"Resveratrol is rapidly metabolized in athymic (Nu\/Nu) mice and does not inhibit human melanoma xenograft tumor growth","volume":"136","author":"Niles","year":"2006","journal-title":"J. Nutr."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0891-5849(02)00911-5","article-title":"Original contribution: Inhibition of cancer growth by resveratrol is related to its low bioavailability","volume":"33","author":"Asensi","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Guan, H., Singh, N.P., Singh, U.P., Nagarkatti, P.S., and Nagarkatti, M. (2012). Resveratrol prevents endothelial cells injury in high-dose interleukin-2 therapy against melanoma. PLoS One, 7.","DOI":"10.1371\/journal.pone.0035650"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/biof.1068","article-title":"Curcumin in various cancers","volume":"39","author":"Shehzad","year":"2013","journal-title":"Biofactors"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1440-1681.2011.05648.x","article-title":"Discovery of curcumin, a component of golden spice, and its miraculous biological activities","volume":"39","author":"Gupta","year":"2012","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.canlet.2008.03.025","article-title":"Curcumin and cancer: An \u201cold-age\u201d disease with an \u201cage-old\u201d solution","volume":"267","author":"Anand","year":"2008","journal-title":"Cancer Lett."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bbrc.2014.04.024","article-title":"Curcumin-induced melanoma cell death is associated with mitochondrial permeability transition pore (mPTP) opening","volume":"448","author":"Qiu","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1006\/excr.2001.5381","article-title":"Curcumin induces apoptosis in human melanoma cells through a Fas Receptor\/Caspase-8 Pathway Independent of p53","volume":"271","author":"Bush","year":"2001","journal-title":"Exp. Cell. Res."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Tsai, K.D., Yang, S.M., Tseng, M.J., Lin, J.C., Hsu, J.D., Lee, Y.J., and Cherng, J.M. (2012). Curcumin protects against UVB-induced skin cancers in SKH-1 hairless mouse: Analysis of early molecular markers in carcinogenesis. Evid. Based Complement. Alternat. Med., 2012.","DOI":"10.1155\/2012\/593952"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Dahmke, I.N., Backes, C., Rudzitis-Auth, J., Laschke, M.W., Leidinger, P., Menger, M.D., Meese, E., and Mahlknecht, U. (2013). Curcumin intake affects miRNA signature in murine melanoma with mmu-miR-205-5p most significantly altered. PLoS One, 8.","DOI":"10.1371\/journal.pone.0081122"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/0194599811400711","article-title":"Curcumin inhibits skin squamous cell carcinoma tumor growth in vivo","volume":"145","author":"Phillips","year":"2011","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1016\/j.biomaterials.2013.12.090","article-title":"Curcumin nanoformulations: A review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment","volume":"35","author":"Naksuriya","year":"2014","journal-title":"Biomaterials"},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Mimeault, M., and Batra, S.K. (2011). Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy. Chin. Med., 6.","DOI":"10.1186\/1749-8546-6-31"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.ijpharm.2013.06.052","article-title":"Selection of high efficient transdermal lipid vesicle for curcumin skin delivery","volume":"454","author":"Zhao","year":"2013","journal-title":"Int. J. Pharm."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.colsurfb.2010.08.018","article-title":"Terpene microemulsions for transdermal curcumin delivery: Effects of terpenes and cosurfactants","volume":"82","author":"Liu","year":"2011","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jmhi.2012.10.005","article-title":"Curcumin-Piperine\/Curcumin-Quercetin\/Curcumin-Silibinin dual drug-loaded nanoparticulate combination therapy: A novel approach to target and treat multidrug-resistant cancers","volume":"7","author":"Moorthi","year":"2013","journal-title":"J. Med. Hypotheses Ideas"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.mrrev.2006.10.004","article-title":"Sulforaphane as a promising molecule for fighting cancer","volume":"635","author":"Fimognari","year":"2007","journal-title":"Mutat. Res."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3109\/01480545.2010.538694","article-title":"Induction of apoptosis by sulforaphane in highly metastatic B16F-10 melanoma cells","volume":"34","author":"Hamsa","year":"2011","journal-title":"Drug Chem. Toxicol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1007\/s10495-013-0959-7","article-title":"Sulforaphane-induced apoptosis involves p53 and p38 in melanoma cells","volume":"19","author":"Rudolf","year":"2014","journal-title":"Apoptosis"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/08923970701511728","article-title":"Modulation of cell-mediated immune response in B16F-10 melanoma-induced metastatic tumor-bearing C57BL\/6 mice by sulforaphane","volume":"29","author":"Thejass","year":"2007","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1016\/j.lfs.2005.12.038","article-title":"Antimetastatic activity of Sulforaphane","volume":"78","author":"Thejass","year":"2006","journal-title":"Life Sci."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1021\/jf062630b","article-title":"Kinetics of the stability of broccoli (Brassica oleracea cv. italica) myrosinase and isothiocyanates in broccoli juice during pressure\/temperature treatments","volume":"55","author":"Eylen","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ijpharm.2009.11.009","article-title":"Development of sulforaphane-encapsulated microspheres for cancer epigenetic therapy","volume":"386","author":"Do","year":"2010","journal-title":"Int. J. Pharm."},{"key":"ref_199","first-page":"1393","article-title":"Formulation and evaluation of drug-loaded targeted magnetic microspheres for cancer therapy","volume":"8","author":"Enriquez","year":"2013","journal-title":"Int. J. Nanomedicine"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jphotobiol.2008.01.011","article-title":"Hypericin phototoxicity induces different modes of cell death in melanoma and human skin cells","volume":"91","author":"Davids","year":"2008","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S1357-2725(01)00126-1","article-title":"Hypericin in cancer treatment: More light on the way","volume":"34","author":"Agostinis","year":"2002","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jphotobiol.2010.09.012","article-title":"Photodynamic therapy using topically applied hypericin: Comparative effect with methyl-aminolevulinic acid on UV induced skin tumours","volume":"102","author":"Boiy","year":"2011","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jphotobiol.2005.11.001","article-title":"Photophysical properties of Hypericum perforatum L. extrSacts-novel photosensitizers for PDT","volume":"82","author":"Skalkos","year":"2006","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/cpr.12020","article-title":"Hypericum perforatum L. subsp. perforatum induces inhibition of free radicals and enhanced phototoxicity in human melanoma cells under ultraviolet light","volume":"46","author":"Menichini","year":"2013","journal-title":"Cell Prolif."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1351\/PAC-CON-11-10-08","article-title":"Antiproliferative withanolides from the Solanaceae: A structure-activity study","volume":"84","author":"Zhang","year":"2012","journal-title":"Pure Appl. Chem."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1177\/1534735408330715","article-title":"Effect of withaferin A on the development and decay of thermotolerance in B16F1 melanoma: A preliminary study","volume":"8","author":"Kalthur","year":"2009","journal-title":"Integr. Cancer Ther."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1177\/1534735410378664","article-title":"Enhancement of the response of B16F1 melanoma to fractionated radiotherapy and prolongation of survival by withaferin A and\/or hyperthermia","volume":"9","author":"Kalthur","year":"2010","journal-title":"Integr. Cancer Ther."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1007\/s10495-011-0625-x","article-title":"Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2","volume":"16","author":"Mayola","year":"2011","journal-title":"Apoptosis"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/ptr.1378","article-title":"Effect of Withania somnifera on B16F-10 melanoma induced metastasis in mice","volume":"18","author":"Leyon","year":"2004","journal-title":"Phytother. Res."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s00280-009-1093-7","article-title":"Induction of necrosis and cell cycle arrest in murine cancer cell lines by Melaleuca alternifolia (tea tree) oil and terpinen-4-ol","volume":"65","author":"Greay","year":"2010","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s00280-010-1267-3","article-title":"Inhibition of established subcutaneous murine tumour growth with topical Melaleuca alternifolia (tea tree) oil","volume":"66","author":"Greay","year":"2010","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1046\/j.0022-202X.2004.22236.x","article-title":"Terpinen-4-ol, the main component of Melaleuca alternifolia (tea tree) oil inhibits the in vitro growth of human melanoma cells","volume":"122","author":"Calcabrini","year":"2004","journal-title":"J. Invest. Dermatol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.bbrc.2005.07.076","article-title":"[6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo","volume":"335","author":"Sanghwa","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cbi.2009.05.012","article-title":"[6]-Gingerol induces reactive oxygen species regulated mitochondrial cell death pathway in human epidermoid carcinoma A431 cells","volume":"181","author":"Nigam","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/BF02980033","article-title":"Antitumor activity of the Korean mistletoe lectin is attributed to activation of macrophages and NK cells","volume":"26","author":"Yoon","year":"2003","journal-title":"Arch. Pharm. Res."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0192-0561(98)00024-1","article-title":"Prophylactic effect of Korean mistletoe (Viscum album coloratum) extract on tumor metastasis is mediated by enhancement of NK cell activity","volume":"20","author":"Yoon","year":"1998","journal-title":"Int. J. Immunopharmacol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0304-3835(95)03956-W","article-title":"Inhibitory effect of Korean mistletoe (Viscum album coloratum) extract on tumour angiogenesis and metastasis of haematogenous and non-haematogenous tumour cells in mice","volume":"97","author":"Yoon","year":"1995","journal-title":"Cancer Lett."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.tox.2004.09.009","article-title":"Influence of mistletoe lectins and cytokines induced by them on cell prolifertion of human melanoma cells in vitro","volume":"207","author":"Thies","year":"2005","journal-title":"Toxicology"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.canlet.2005.11.016","article-title":"Interleukin-12 is associated with the in vivo anti-tumor effect of mistletoe extracts in B16 mouse melanoma","volume":"243","author":"Delignat","year":"2006","journal-title":"Cancer Lett."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1002\/ptr.4604","article-title":"A novel triterpene extract from mistletoe induces rapid apoptosis in murine B16.F10 melanoma cells","volume":"26","author":"Schempp","year":"2012","journal-title":"Phytother. Res."},{"key":"ref_221","first-page":"38","article-title":"Safety and efficacy of the long-term adjuvant treatment of primary intermediate- to high-risk malignant melanoma (UICC\/AJCC stage II and III) with a standardized fermented European mistletoe (Viscum album L.) extract. Results from a multicenter, comparative, epidemiological cohort study in Germany and Switzerland","volume":"55","author":"Augustin","year":"2005","journal-title":"Arzneimittel-Forsch."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1089\/acm.2007.6175","article-title":"Successful treatment of metastatic malignant melanoma with Viscum album extract (Iscador\u00ae M)","volume":"13","author":"Kirsch","year":"2007","journal-title":"J. Altern. Complement. Med."},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Jim\u00e9nez-Medina, E., Garcia-Lora, A., Paco, L., Algarra, I., Collado, A., and Garrido, F. (2006). A new extract of the plant Calendula officinalis produces a dual vitro effect: Cytotoxic anti-tumor activity and lymphocyte activation. BMC Cancer, 6.","DOI":"10.1186\/1471-2407-6-119"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1021\/np068016b","article-title":"Anti-inflammatory, anti-tumor-promoting, and cytotoxic activities of constituents of marigold (Calendula officinalis) flowers","volume":"69","author":"Ukiya","year":"2006","journal-title":"J. Nat. Prod."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/ptr.4807","article-title":"Chamomile and marigold tea: Chemical characterization and evaluation of anticancer activity","volume":"27","author":"Savikin","year":"2013","journal-title":"Phytother. Res."},{"key":"ref_226","first-page":"1773","article-title":"Inhibition of metastasis of B16F-10 melanoma cells in C57BL\/6 mice by an extract of Calendula officinalis L flowers","volume":"11","author":"Preethi","year":"2010","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1080\/10408398.2010.490883","article-title":"Rosemary and cancer prevention: Preclinical perspectives","volume":"51","author":"Ngo","year":"2011","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bcp.2004.09.019","article-title":"Carnosol inhibits the invasion of B16\/F10 mouse melanoma cells by suppressing metalloproteinase-9 through down-regulating nuclear factor-kappaB and c-Jun","volume":"69","author":"Huang","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1111\/j.1751-1097.2012.01156.x","article-title":"Modulation of photochemical damage in normal and malignant cells by naturally occurring compounds","volume":"88","author":"Lee","year":"2012","journal-title":"Photochem. Photobiol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.intimp.2008.02.013","article-title":"Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-\u03baB mediated activation of bcl-2 in B16F-10 melanoma cells","volume":"8","author":"Manu","year":"2008","journal-title":"Int. Immunopharmacol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3109\/10715762.2012.656101","article-title":"Sensitization of ionizing radiation-induced apoptosis by ursolic acid","volume":"46","author":"Koh","year":"2012","journal-title":"Free Radic. Res."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1007\/s10495-013-0962-z","article-title":"Ursolic acid differentially modulates apoptosis in skin melanoma and retinal pigment epithelial cells exposed to UV-VIS broadband radiation","volume":"19","author":"Lee","year":"2014","journal-title":"Apoptosis"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1177\/1534735410367647","article-title":"Antiangiogenic activity of ursolic acid","volume":"9","author":"Kanjoormana","year":"2010","journal-title":"Integr. Cancer Ther."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"233","DOI":"10.4103\/2229-5186.99595","article-title":"Cytotoxicity study of plant Aloe vera (Linn)","volume":"3","author":"Chandu","year":"2012","journal-title":"Chron. Young Sci."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.lfs.2010.07.003","article-title":"Antitumor properties of aloe-emodin and induction of transglutaminase 2 activity in B16\u2013F10 melanoma cells","volume":"87","author":"Tabolacci","year":"2010","journal-title":"Life Sci."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1016\/j.fct.2012.05.047","article-title":"Cell-type dependent response of melanoma cells to aloe emodin","volume":"50","author":"Radovic","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00726-011-1166-x","article-title":"Aloin enhances cisplatin antineoplastic activity in B16-F10 melanoma cells by transglutaminase-induced differentiation","volume":"44","author":"Tabolacci","year":"2013","journal-title":"Amino Acids"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"582","DOI":"10.5897\/AJPP11.079","article-title":"Eupatilin: A flavonoid compound isolated from the artemisia plant, induces apoptosis and G2\/M phase cell cycle arrest in human melanoma A375 cells","volume":"5","author":"Rasul","year":"2011","journal-title":"Afr. J. Pharm. Pharmacol."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.phytol.2012.05.018","article-title":"Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells","volume":"5","author":"Priestap","year":"2012","journal-title":"Phytochem. Lett."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jchromb.2013.09.027","article-title":"Isolation, cytotoxicity evaluation and HPLC-quantification of the chemical constituents from Artemisia amygdalina Decne","volume":"940","author":"Lone","year":"2013","journal-title":"J. Chromatogr. B Biomed. Appl."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1080\/10412905.2013.820670","article-title":"Chemical composition and bioactivity of the essential oil of Artemisia anomala from China","volume":"25","author":"Zhao","year":"2013","journal-title":"J. Essent. Oil Res."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bej.2013.03.009","article-title":"Alpinia oxyphylla Miq. bioactive extracts from supercritical fluid carbon dioxide extraction","volume":"78","author":"Lee","year":"2013","journal-title":"Biochem. Eng. J."},{"key":"ref_243","doi-asserted-by":"crossref","unstructured":"Lo, C.Y., Liu, P.L., Lin, L.C., Chen, Y.T., Hseu, Y.C., Wen, Z.H., and Wang, H.M. (2013). Antimelanoma and antityrosinase from Alpinia galangal constituents. Sci. World J., 2013.","DOI":"10.1155\/2013\/186505"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s10616-012-9499-1","article-title":"Galangin induces B16F10 melanoma cell apoptosis via mitochondrial pathway and sustained activation of p38 MAPK","volume":"65","author":"Zhang","year":"2013","journal-title":"Cytotechnology"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/jcb.24312","article-title":"Galangin inhibits tumor growth and metastasis of B16F10 melanoma","volume":"114","author":"Zhang","year":"2013","journal-title":"J. Cell. Biochem."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1023\/A:1011398120476","article-title":"Advising patients on the use of complementary and alternative medicine","volume":"26","author":"Jonas","year":"2001","journal-title":"Appl. Psychophysiol. Biofeedback"},{"key":"ref_247","doi-asserted-by":"crossref","unstructured":"Joos, S., Glassen, K., and Musselmann, B. (2012). Herbal medicine in primary healthcare in Germany: The patient\u2019s perspective. Evid. Based Complement. Alternat. Med.","DOI":"10.1155\/2012\/294638"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.7326\/0003-4819-142-12_Part_2-200506211-00003","article-title":"Challenges in systematic reviews of Complementary and Alternative Medicine topics","volume":"142","author":"Shekelle","year":"2005","journal-title":"Ann. Intern. Med."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.jclinepi.2006.11.018","article-title":"Matched-pair study showed higher quality of placebo-controlled trials in Western phytotherapy than conventional medicine","volume":"60","author":"Nartey","year":"2007","journal-title":"J. Clin. Epidemiol."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev.pharmtox.43.100901.135757","article-title":"Complementary and alternative therapeutics: Rigorous research is needed to support claims","volume":"43","author":"Kinsel","year":"2003","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1177\/2156587211429351","article-title":"Beyond randomized controlled trials: Evidence in complementary medicine","volume":"17","author":"Golden","year":"2012","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1142\/S0192415X11009081","article-title":"Scientific publications from Mainland China, Taiwan, and Hong Kong in integrative and complementary medicine journals: A ten-year literature survey","volume":"39","author":"Li","year":"2011","journal-title":"Am. J. Chin. Med."},{"key":"ref_253","first-page":"13","article-title":"Evidence Based Medicine and CAM: A review","volume":"43","author":"Maino","year":"2012","journal-title":"Optom. Vis. Dev."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1089\/acm.2011.0110","article-title":"Portrayal of Complementary and Alternative Medicine for Cancer by Top Online News Sites","volume":"18","author":"Price","year":"2012","journal-title":"J. Altern. Complement. Med."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/19\/8\/11679\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:14:27Z","timestamp":1760217267000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/19\/8\/11679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,6]]},"references-count":254,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,8]]}},"alternative-id":["molecules190811679"],"URL":"https:\/\/doi.org\/10.3390\/molecules190811679","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,6]]}}}