{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:15:50Z","timestamp":1787505350931,"version":"build-2736575974"},"reference-count":23,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T00:00:00Z","timestamp":1408406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this study, we report the antibacterial activities of six polyphenols (i.e., luteolin, quercetin, scutellarin, apigenin, chlorogenic acid, and resveratrol) against 29 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA), and in vitro antibacterial activities of two-drug combinations. All of the MRSA strains evaluated were clinical isolates from patients with MRSA bacteremia. The antibacterial activities were determined by agar dilution method, and the two-drug antibacterial activities were determined by the checkerboard agar dilution method. It was found that luteolin, quercetin and resveratrol show obvious antibacterial activities against MRSA, and the results of  two-drug antibacterial activity show either synergy or additivity, without evidences of antagonistic effects.<\/jats:p>","DOI":"10.3390\/molecules190812630","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T10:40:39Z","timestamp":1408444839000},"page":"12630-12639","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Studies of the in Vitro Antibacterial Activities of Several Polyphenols against Clinical Isolates of Methicillin-Resistant Staphylococcus aureus"],"prefix":"10.3390","volume":"19","author":[{"given":"Yanli","family":"Su","sequence":"first","affiliation":[{"name":"Department of Infection and Critical Care Medicine, Beijing Friendship Hospital,  Capital Medical University, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Ma","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Infection and Critical Care Medicine, Beijing Friendship Hospital,  Capital Medical University, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infection and Critical Care Medicine, Beijing Friendship Hospital,  Capital Medical University, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infection and Critical Care Medicine, Beijing Friendship Hospital,  Capital Medical University, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/S0140-6736(06)68853-3","article-title":"Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat","volume":"368","author":"Grundmann","year":"2006","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"10322","DOI":"10.3390\/molecules170910322","article-title":"Antibacterial and synergy of berberines with antibacterial agents against clinical multi-drug resistant isolates of methicillin-resistant Staphylococcus aureus (MRSA)","volume":"17","author":"Zuo","year":"2012","journal-title":"Molecules"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1469-0691.2007.01721.x","article-title":"Combating resistance in a challenging, changing environment","volume":"13","author":"Goldstein","year":"2007","journal-title":"Clin. 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