{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T07:43:48Z","timestamp":1776757428304,"version":"3.51.2"},"reference-count":39,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T00:00:00Z","timestamp":1409097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The goal of this study was to determine the rat lens aldose reductase-inhibitory effects of 95% ethanol extracts from the leaves of C. esculenta and, its organic solvent soluble fractions, including the dichloromethane (CH2Cl2), ethyl acetate (EtOAc),  n-butanol (BuOH) and water (H2O) layers, using dl-glyceraldehyde as a substrate. Ten compounds, namely tryptophan (1), orientin (2), isoorientin (3), vitexin (4), isovitexin (5), luteolin-7-O-glucoside (6), luteolin-7-O-rutinoside (7), rosmarinic acid (8), 1-O-feruloyl-d-glucoside (9) and 1-O-caffeoyl-d-glucoside (10) were isolated from the EtOAc and BuOH fractions of C. esculenta. The structures of compounds 1\u201310 were elucidated by spectroscopic methods and comparison with previous reports. All the isolates were subjected to an in vitro bioassay to evaluate their inhibitory activity against rat lens aldose reductase. Among tested compounds, compounds 2 and 3 significantly inhibited rat lens aldose reductase, with IC50 values of 1.65 and 1.92 \u03bcM, respectively. Notably, the inhibitory activity of orientin was 3.9 times greater than that of the positive control, quercetin (4.12 \u03bcM). However, the isolated compounds showed only moderate ABTS+ [2,29-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)] activity. These results suggest that flavonoid derivatives from Colocasia esculenta (L.) Schott represent potential compounds for the prevention and\/or treatment of diabetic complications.<\/jats:p>","DOI":"10.3390\/molecules190913212","type":"journal-article","created":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T09:52:39Z","timestamp":1409133159000},"page":"13212-13224","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Inhibitory Effects of Colocasia esculenta (L.) Schott Constituents on Aldose Reductase"],"prefix":"10.3390","volume":"19","author":[{"given":"Hong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacology, College of Medicine, Hallym University, 200-702 Chuncheon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Hallym University, 200-702 Chuncheon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beom","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Hallym University, 200-702 Chuncheon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Hallym University, 200-702 Chuncheon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4548-1285","authenticated-orcid":false,"given":"Soon","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Hallym University, 200-702 Chuncheon, Korea"},{"name":"Department of Center for Aging and Health Care, Hallym University, 200-702 Chuncheon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2014,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","article-title":"Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"7592","DOI":"10.1016\/j.bmc.2006.07.002","article-title":"Aldose reductase inhibitory effect by tectorigenin derivatives from viola hondoensis","volume":"14","author":"Moon","year":"2006","journal-title":"Bioorg. 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