{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:37:14Z","timestamp":1790397434279,"version":"4.1.0"},"reference-count":45,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T00:00:00Z","timestamp":1409184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Twelve hybrids derived from triclosan were obtained via Williamson etherification of O-triclosan alkyl bromide plus chalcone and O-coumarin or O-chromone alkyl bromide plus triclosan, respectively. Structures of the products were elucidated by spectroscopic analysis. The synthesized compounds were evaluated for antileishmanial activity against L. (V) panamensis amastigotes. Cytotoxic activity was also evaluated against mammalian U-937 cells. Compounds 7\u20139 and 17, were active against Leishmania parasites (EC50 = 9.4; 10.2; 13.5 and 27.5 \u00b5g\/mL, respectively) and showed no toxicity toward mammalian cells (&gt;200 \u00b5g\/mL). They are potential candidates for antileishmanial drug development. Compounds 25\u201327, were active and cytotoxic. Further studies using other cell types are needed in order to discriminate whether the toxicity shown by these compounds is against tumor or non-tumor cells. The results indicate that compounds containing small alkyl chains show better selectivity indices. Moreover, Michael acceptor moieties may modify both the leishmanicidal activity and cytotoxicity. Further studies are required to evaluate if the in vitro activity against Leishmania panamensis demonstrated here is also observed in vivo.<\/jats:p>","DOI":"10.3390\/molecules190913251","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T10:37:35Z","timestamp":1409222255000},"page":"13251-13266","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Synthesis, Leishmanicidal and Cytotoxic Activity of  Triclosan-Chalcone, Triclosan-Chromone and  Triclosan-Coumarin Hybrids"],"prefix":"10.3390","volume":"19","author":[{"given":"Elver","family":"Otero","sequence":"first","affiliation":[{"name":"Qu\u00edmica de Plantas Colombianas, Instituto de Qu\u00edmica, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia UdeA, Calle 70 No. 52-21, A.A 1226 Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e1n","family":"Vergara","sequence":"additional","affiliation":[{"name":"Qu\u00edmica de Plantas Colombianas, Instituto de Qu\u00edmica, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia UdeA, Calle 70 No. 52-21, A.A 1226 Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2752-4931","authenticated-orcid":false,"given":"Sara","family":"Robledo","sequence":"additional","affiliation":[{"name":"PECET, Instituto de Investigaciones M\u00e9dicas, Facultad de Medicina,  Universidad de Antioquia UdeA, Calle 62 No. 52-59, Lab 632, A.A 1226 Medell\u00edn, Colombia"},{"name":"CIDEPRO-Center for Development of Products against Tropical Diseases, Carrera 53 No 61-30, Sede de Investigacion Universitaria, A.A 1226 Medellin, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson","family":"Cardona","sequence":"additional","affiliation":[{"name":"Qu\u00edmica de Plantas Colombianas, Instituto de Qu\u00edmica, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia UdeA, Calle 70 No. 52-21, A.A 1226 Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Carda","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Inorg\u00e1nica y Org\u00e1nica, Universidad Jaume I, E-12071 Castell\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"V\u00e9lez","sequence":"additional","affiliation":[{"name":"PECET, Instituto de Investigaciones M\u00e9dicas, Facultad de Medicina,  Universidad de Antioquia UdeA, Calle 62 No. 52-59, Lab 632, A.A 1226 Medell\u00edn, Colombia"},{"name":"CIDEPRO-Center for Development of Products against Tropical Diseases, Carrera 53 No 61-30, Sede de Investigacion Universitaria, A.A 1226 Medellin, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Rojas","sequence":"additional","affiliation":[{"name":"SIN-BIO-ME-NA, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia UdeA, Calle 70 No. 52-21, A.A 1226 Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Ot\u00e1lvaro","sequence":"additional","affiliation":[{"name":"SIN-BIO-ME-NA, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia UdeA, Calle 70 No. 52-21, A.A 1226 Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e35671","DOI":"10.1371\/journal.pone.0035671","article-title":"WHO Leishmaniasis Control Team. 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