{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:09:36Z","timestamp":1785892176683,"version":"3.56.0"},"reference-count":37,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T00:00:00Z","timestamp":1409616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A one-pot preparation of pyridyl isothiocyanates (ITCs) from their corresponding amines has been developed. This method involves aqueous iron(III) chloride-mediated desulfurization of a dithiocarbamate salt that is generated in situ by treatment of an amine with carbon disulfide in the present of DABCO or sodium hydride. The choice of base is of decisive importance for the formation of the dithiocarbamate salts. This one-pot process works well for a wide range of pyridyl ITCs. Utilizing this protocol, some highly  electron-deficient pyridyl and aryl ITCs are obtained in moderate to good yields.<\/jats:p>","DOI":"10.3390\/molecules190913631","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T10:12:38Z","timestamp":1409652758000},"page":"13631-13642","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A One-Pot Approach to Pyridyl Isothiocyanates from Amines"],"prefix":"10.3390","volume":"19","author":[{"given":"Hao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Applied Chemistry, College of Science, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Quan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, College of Science, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, College of Science, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Bo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, College of Science, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, College of Science, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang-Zhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, College of Science, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,9,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Pedras, M.S.C., Zheng, Q.-A., and Gadagi, R.S. 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