{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T02:31:54Z","timestamp":1768530714883,"version":"3.49.0"},"reference-count":35,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T00:00:00Z","timestamp":1409616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Pathogenic fungi are one of the main causes of hospital-related infections. Since conventional antifungals have become less effective because of the increasing fungal resistance to the standard drugs, the need for new agents is becoming urgent. Herein we report a synthesis of a series of novel N-[imino-(1-oxo-(1H)-phthalazin-2-yl)methyl]-benzenesulfonamide derivatives with in vitro activity against yeast-like fungi isolated from the oral cavity and respiratory tract of patients with candidiasis. These compounds were synthesized by the one-step or two-step reactions of 1-(2-alkylthiobenzensulfonyl)-2-aminoguanidines with the appropriate ortho-carbonyl benzoic acids. The biological study revealed that new derivatives have shown significant growth-inhibitory activity, superior or comparable, than those of the reference drug fluconazole. The most promising activities were observed against Candida albicans, with inhibition at least 1\u20133 (12.5%\u201337.5%) of the eight tested strains at the low MIC level of \u22646.2\u201325 \u00b5g\/mL.<\/jats:p>","DOI":"10.3390\/molecules190913704","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T10:12:38Z","timestamp":1409652758000},"page":"13704-13723","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Synthesis and Anti-Yeast Evaluation of Novel 2-Alkylthio-4-chloro-5-methyl-N-[imino-(1-oxo-(1H)-phthalazin-2-yl)methyl]benzenesulfonamide Derivatives"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2794-5031","authenticated-orcid":false,"given":"Jaros\u0142aw","family":"S\u0142awi\u0144ski","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry, Medical University of Gda\u0144sk, Al. Gen. J. Hallera 107,  Gda\u0144sk 80-416, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aneta","family":"Pogorzelska","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Medical University of Gda\u0144sk, Al. Gen. J. Hallera 107,  Gda\u0144sk 80-416, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"\u017bo\u0142nowska","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Medical University of Gda\u0144sk, Al. Gen. J. Hallera 107,  Gda\u0144sk 80-416, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"K\u0119dzia","sequence":"additional","affiliation":[{"name":"Department of Oral Microbiology, Medical University of Gda\u0144sk, ul. Do Studzienki 38,  Gda\u0144sk 80-227, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Zi\u00f3\u0142kowska-Klinkosz","sequence":"additional","affiliation":[{"name":"Department of Oral Microbiology, Medical University of Gda\u0144sk, ul. Do Studzienki 38,  Gda\u0144sk 80-227, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Kwapisz","sequence":"additional","affiliation":[{"name":"Department of Oral Microbiology, Medical University of Gda\u0144sk, ul. Do Studzienki 38,  Gda\u0144sk 80-227, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2014,9,2]]},"reference":[{"key":"ref_1","first-page":"1068","article-title":"The epidemiology of fungal infections in patients with hematologic malignancies: The SEIFEM-2004 study","volume":"91","author":"Pagano","year":"2006","journal-title":"Haematol. Hematol. 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