{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:58:24Z","timestamp":1777532304013,"version":"3.51.4"},"reference-count":32,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T00:00:00Z","timestamp":1414713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Simarouba amara stem bark decoction has been traditionally used in Brazil to treat malaria, inflammation, fever, abdominal pain, diarrhea, wounds and as a tonic. In this study, we investigate the hepatoprotective effects of the aqueous extract of S. amara stem bark (SAAE) on CCl4-induced hepatic damage in rats. SAAE was evaluated by high performance liquid chromatography. The animals were divided into six groups (n = 6\/group). Groups I (vehicle\u2014corn oil), II (control-CCl4), III, IV, V and VI were pretreated during 10 consecutive days, once a day p.o, with Legalon\u00ae 50 mg\/kg b.w, SAAE at doses 100, 250 and 500 mg\/kg b.w, respectively. The hepatotoxicity was induced on 11th day with 2 mL\/kg of 20% CCl4 solution. 24 h after injury, the blood samples were collected and their livers were removed to biochemical and immunohistochemical analyzes. The SAAE decreased the levels of liver markers and lipid peroxidation in all doses and increased the catalase levels at doses 250 and 500 mg\/kg. Immunohistochemical results suggested hepatocyte proliferation in all doses. These results may be related to catechins present in SAAE. Thus, SAAE prevented the oxidative damage at the same time that increased regenerative and reparative capacities of the liver.<\/jats:p>","DOI":"10.3390\/molecules191117735","type":"journal-article","created":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T10:32:28Z","timestamp":1414751548000},"page":"17735-17746","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hepatoprotective Effect of the Aqueous Extract of Simarouba amara Aublet (Simaroubaceae) Stem Bark against Carbon Tetrachloride (CCl4)-Induced Hepatic Damage in Rats"],"prefix":"10.3390","volume":"19","author":[{"given":"H\u00e9lida","family":"Maranh\u00e3o","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Universidade Federal de Pernambuco,  Recife 50740-521, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Universidade Federal de Pernambuco,  Recife 50740-521, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa","family":"Rolim","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Universidade Federal de Pernambuco,  Recife 50740-521, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Neto","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Universidade Federal de Pernambuco,  Recife 50740-521, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacinto","family":"Neto","sequence":"additional","affiliation":[{"name":"Department of Histology and Embriology, Universidade Federal de Pernambuco,  Recife 50670-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reginaldo","family":"Filho","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport Science, Universidade Federal de Pernambuco,  Vit\u00f3ria de Santo Ant\u00e3o 55608-680, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport Science, Universidade Federal de Pernambuco,  Vit\u00f3ria de Santo Ant\u00e3o 55608-680, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Costa-Silva","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport Science, Universidade Federal de Pernambuco,  Vit\u00f3ria de Santo Ant\u00e3o 55608-680, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Universidade Federal de Pernambuco,  Vit\u00f3ria de Santo Ant\u00e3o 55608-680, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almir","family":"Wanderley","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Universidade Federal de Pernambuco,  Recife 50740-521, Brazil"},{"name":"Department of Physiology and Pharmacology, Universidade Federal de Pernambuco,  Recife 50760-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2014,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1590\/S0001-37652002000300004","article-title":"Chemical constituents of Simarouba versicolor","volume":"73","author":"Arriaga","year":"2002","journal-title":"An. 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