{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:00:56Z","timestamp":1792425656703,"version":"4.5.0"},"reference-count":26,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T00:00:00Z","timestamp":1416268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Colciencias-COLOMBIA","award":["111548925424"],"award-info":[{"award-number":["111548925424"]}]},{"name":"Cidepro"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Six derivatives of the known biopesticide rotenone were prepared by several chemical transformations. Rotenone and its derivatives showed differential in vitro antiparasitic activity and selective cytotoxicity. In general, compounds were more active against Plasmodium falciparum than Leishmania panamensis. Rotenone had an EC50 of  19.0 \u00b5M against P. falciparum, and 127.2 \u00b5M against L. panamensis. Although chemical transformation does not improve its biological profile against P. falciparum, three of its derivatives showed a significant level of action within an adequate range of activity with EC50 values &lt; 50.0 \u00b5M. This antiplasmodial activity was not due to red blood cell hemolysis, since LC50 was &gt;&gt;400 \u00b5M. On the other hand, all derivatives displayed a  non-specific cytotoxicity on several cell lines and primary human cell cultures.<\/jats:p>","DOI":"10.3390\/molecules191118911","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T11:39:36Z","timestamp":1416310776000},"page":"18911-18922","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Preparation of Rotenone Derivatives and in Vitro Analysis of Their Antimalarial, Antileishmanial and Selective  Cytotoxic Activities"],"prefix":"10.3390","volume":"19","author":[{"given":"Yulieth","family":"Upegui","sequence":"first","affiliation":[{"name":"PECET, Instituto de Investigaciones M\u00e9dicas, Facultad de Medicina, Universidad de Antioquia,  Calle 70 #52-21, Medell\u00edn 050010, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Gil","sequence":"additional","affiliation":[{"name":"Grupo Qu\u00edmica Org\u00e1nica de Productos Naturales, Instituto de Qu\u00edmica, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia, Calle 70 #52-21, Medell\u00edn 050010, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiston","family":"Qui\u00f1ones","sequence":"additional","affiliation":[{"name":"Grupo Qu\u00edmica Org\u00e1nica de Productos Naturales, Instituto de Qu\u00edmica, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia, Calle 70 #52-21, Medell\u00edn 050010, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Torres","sequence":"additional","affiliation":[{"name":"Grupo Qu\u00edmica Org\u00e1nica de Productos Naturales, Instituto de Qu\u00edmica, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia, Calle 70 #52-21, Medell\u00edn 050010, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Escobar","sequence":"additional","affiliation":[{"name":"Grupo Qu\u00edmica Org\u00e1nica de Productos Naturales, Instituto de Qu\u00edmica, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia, Calle 70 #52-21, Medell\u00edn 050010, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Robledo","sequence":"additional","affiliation":[{"name":"PECET, Instituto de Investigaciones M\u00e9dicas, Facultad de Medicina, Universidad de Antioquia,  Calle 70 #52-21, Medell\u00edn 050010, Colombia"},{"name":"Center for Development of Products against Tropical Diseases-CIDEPRO, Medell\u00edn 050010, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Echeverri","sequence":"additional","affiliation":[{"name":"Grupo Qu\u00edmica Org\u00e1nica de Productos Naturales, Instituto de Qu\u00edmica, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia, Calle 70 #52-21, Medell\u00edn 050010, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,11,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/1756-3305-4-234","article-title":"Neglected tropical diseases and the millennium development goals: Why the \u201cother diseases\u201d matter: Reality versus rhetoric","volume":"4","author":"Molyneux","year":"2011","journal-title":"Parasit Vector."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1242\/jeb.00589","article-title":"Antimalarial drug discovery: Old and new approaches","volume":"206","author":"Rosenthal","year":"2003","journal-title":"J. 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