{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:27:07Z","timestamp":1760243227603,"version":"build-2065373602"},"reference-count":15,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T00:00:00Z","timestamp":1416355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>We describe a ligand-based approach towards compounds with more specific targeting for Burkitt\u2019s lymphoma. Using three-dimensional ligand-based similarity searches and a previously described hit compound, we have identified six compounds that are chemically different but with similar spatial conformations. Biological evaluation revealed that one compound has better growth inhibition and improved selectivity towards Burkitt\u2019s lymphoma cells than the query compound. However, initial mechanism-of-action studies show a different target profile in comparison with the previous hit compound, which does not involve the inhibition of the proteasome or the NF\u03baB pathway. The data from this study provide a solid basis for further efforts in the search for selective agents against Burkitt\u2019s lymphoma.<\/jats:p>","DOI":"10.3390\/molecules191119209","type":"journal-article","created":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T10:56:41Z","timestamp":1416394601000},"page":"19209-19219","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of Novel Small-Molecule Compounds with  Selective Cytotoxicity for Burkitt\u2019s Lymphoma Cells  Using 3D Ligand-Based Virtual Screening"],"prefix":"10.3390","volume":"19","author":[{"given":"Martina","family":"Gobec","sequence":"first","affiliation":[{"name":"University of Ljubljana, Faculty of Pharmacy, A\u0161ker\u010deva cesta 7, Ljubljana 1000, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izidor","family":"Sosi\u010d","sequence":"additional","affiliation":[{"name":"University of Ljubljana, Faculty of Pharmacy, A\u0161ker\u010deva cesta 7, Ljubljana 1000, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Brus","sequence":"additional","affiliation":[{"name":"University of Ljubljana, Faculty of Pharmacy, A\u0161ker\u010deva cesta 7, Ljubljana 1000, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ale\u0161","family":"Obreza","sequence":"additional","affiliation":[{"name":"University of Ljubljana, Faculty of Pharmacy, A\u0161ker\u010deva cesta 7, Ljubljana 1000, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislav","family":"Gobec","sequence":"additional","affiliation":[{"name":"University of Ljubljana, Faculty of Pharmacy, A\u0161ker\u010deva cesta 7, Ljubljana 1000, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Mlinari\u010d-Ra\u0161\u010dan","sequence":"additional","affiliation":[{"name":"University of Ljubljana, Faculty of Pharmacy, A\u0161ker\u010deva cesta 7, Ljubljana 1000, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2014,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0092-8674(84)90227-7","article-title":"Activation and somatic mutation of the translocated c-myc gene in burkitt lymphoma cells","volume":"36","author":"Taub","year":"1984","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1056\/NEJMoa055759","article-title":"Molecular Diagnosis of Burkitt's Lymphoma","volume":"354","author":"Dave","year":"2006","journal-title":"N. 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