{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:10:56Z","timestamp":1791774656846,"version":"4.3.4"},"reference-count":46,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T00:00:00Z","timestamp":1416873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A series of 12 novel monosubstituted N-benzyl amides of salinomycin (SAL) was synthesized for the first time and characterized by NMR and FT-IR spectroscopic methods. Molecular structures of three salinomycin derivatives in the solid state were determined using single crystal X-ray method. All compounds obtained were screened for their antiproliferative activity against various human cancer cell lines as well as against the most problematic bacteria strains such as methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (MRSE), and Mycobacterium tuberculosis. Novel salinomycin derivatives exhibited potent anticancer activity against drug-resistant cell lines. Additionally, two N-benzyl amides of salinomycin revealed interesting antibacterial activity. The most active were N-benzyl amides of SAL substituted at -ortho position and the least anticancer active derivatives were those substituted at the -para position.<\/jats:p>","DOI":"10.3390\/molecules191219435","type":"journal-article","created":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T11:01:31Z","timestamp":1416913291000},"page":"19435-19459","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Synthesis, Anticancer and Antibacterial Activity of Salinomycin N-Benzyl Amides"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0877-1726","authenticated-orcid":false,"given":"Micha\u0142","family":"Antoszczak","sequence":"first","affiliation":[{"name":"Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89 b, 61-614 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Maj","sequence":"additional","affiliation":[{"name":"Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0775-9242","authenticated-orcid":false,"given":"Agnieszka","family":"Napi\u00f3rkowska","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Tuberculosis and Pulmonary Diseases, P\u0142ocka 26,  01-138 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Stefa\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology, University of Warsaw, Oczki 3, 02-007 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Augustynowicz-Kope\u0107","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Tuberculosis and Pulmonary Diseases, P\u0142ocka 26,  01-138 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4980-6606","authenticated-orcid":false,"given":"Joanna","family":"Wietrzyk","sequence":"additional","affiliation":[{"name":"Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Janczak","sequence":"additional","affiliation":[{"name":"Institute of Low Temperature and Structure Research, Polish Academy of Sciences, P.O. Box 1410, 50-950 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogumil","family":"Brzezinski","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89 b, 61-614 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4770-215X","authenticated-orcid":false,"given":"Adam","family":"Huczy\u0144ski","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89 b, 61-614 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,11,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1747-0285.2011.01287.x","article-title":"Salinomycin\u2014A new cancer drug candidate","volume":"79","year":"2012","journal-title":"Chem. Biol. 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