{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:19:31Z","timestamp":1781104771790,"version":"3.54.1"},"reference-count":16,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T00:00:00Z","timestamp":1417564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Two new N-oxide alkaloids with pyrrolo[1,2-\u03b1]azepine skeleton, namely isoneostemocochinine-N-oxide (1) and neostemocochinine-N-oxide (2), as well as three known alkaloids with pyrido[1,2-\u03b1]azepine skeletons, were isolated and identified from the roots of Stemona cochinchinensis (Stemonaceae). The structures of these compounds were elucidated by 1D- and 2D-NMR spectra and other spectroscopic studies. Additionally, the 1H- and 13C-NMR characteristic of N-oxide Stemona alkaloids was summarized. Stemokerrin showed potent anti-tussive activity on citric acid-induced guinea pig model.<\/jats:p>","DOI":"10.3390\/molecules191220257","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T10:27:09Z","timestamp":1417602429000},"page":"20257-20265","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Two New N-Oxide Alkaloids from Stemona cochinchinensis"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6799-5327","authenticated-orcid":false,"given":"Ligen","family":"Lin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine,  Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China"},{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica,  Chinese Academy of Sciences, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Bao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine,  Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anqi","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine,  Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunping","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica,  Chinese Academy of Sciences, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pham-Huu","family":"Dien","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Chemistry, Hanoi National University of Education, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Ye","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica,  Chinese Academy of Sciences, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,12,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/(SICI)1098-1128(199811)18:6<375::AID-MED2>3.0.CO;2-8","article-title":"Recent advances on bioactive natural products from Chinese medicinal plants","volume":"18","author":"Qin","year":"1998","journal-title":"Med. 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