{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:22:52Z","timestamp":1760242972025,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T00:00:00Z","timestamp":1425945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Synthetic approaches to macrosphelide derivatives, based on medicinal chemistry, are summarized. This review contains conventional medicinal chemistry approaches, combinatorial chemistry, fluorous tagging techniques and affinity chromatography preparation. In addition, advances in their apoptosis-inducing activities are also included.<\/jats:p>","DOI":"10.3390\/molecules20034430","type":"journal-article","created":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T10:59:09Z","timestamp":1425985149000},"page":"4430-4449","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Development of Advanced Macrosphelides: Potent  Anticancer Agents"],"prefix":"10.3390","volume":"20","author":[{"given":"Seung-Mann","family":"Paek","sequence":"first","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences,  Gyeongsang National University, Jinju daero, Jinju, Gyeongnam 660-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1021\/np200906s","article-title":"Natural products as sources of new drugs over the 30 years from 1981 to 2010","volume":"75","author":"Newman","year":"2001","journal-title":"J. Nat. Prod."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1016\/j.bbagen.2013.02.008","article-title":"Natural products: A continuing source of novel drug leads","volume":"1830","author":"Cragg","year":"2013","journal-title":"Biochim. Biophys. Acta-Gen. Subj."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1039\/b702942j","article-title":"Identification of the cellular targets of bioactive small organic molecules using affinity reagents","volume":"37","author":"Leslie","year":"2008","journal-title":"Chem. Soc. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/nm1469","article-title":"Tumor metastasis: Mechanistic insights and clinical challenges","volume":"12","author":"Steeg","year":"2006","journal-title":"Nat. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/138161210789941847","article-title":"Recent advances in cancer therapy: An overview","volume":"16","author":"Urruticoechea","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Teicher, B.A., and Andrews, P.A. (2004). Anticancer drug development guide, Humana Press.","DOI":"10.1007\/978-1-59259-739-0"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrd2155","article-title":"Why is cancer drug discovery so difficult?","volume":"6","author":"Kamb","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.7164\/antibiotics.48.1435","article-title":"Macrosphelide, a novel inhibitor of cell-cell adhesion molecule. I. Taxonomy, fermentation, isolation and biological activities","volume":"48","author":"Hayashi","year":"1995","journal-title":"J. Antibiot."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/chir.10203","article-title":"Total synthesis of (+)-macrosphelides a, c, e, f, and g based on enzymatic function","volume":"15","author":"Akita","year":"2003","journal-title":"Chirality"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.3987\/REV-05-597","article-title":"Recent advances in macrosphelide synthesis","volume":"65","author":"Matsuya","year":"2005","journal-title":"Heterocycles"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"10247","DOI":"10.1021\/ja971657w","article-title":"Relative and Absolute Stereochemistries and Total Synthesis of (+)-Macrosphelides A and B, Potent, Orally Bioavailable Inhibitors of Cell-Cell Adhesion","volume":"119","author":"Sunazuka","year":"1997","journal-title":"J. Am. Chem. Soc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1351\/pac199971091673","article-title":"Recent progress of the research on novel microbial metabolites","volume":"71","author":"Omura","year":"1999","journal-title":"Pure Appl. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1006\/bbrc.2002.6572","article-title":"Macrosphelide B Suppressed Metastasis through Inhibition of Adhesion of sLex\/E-Selectin Molecules","volume":"291","author":"Fukami","year":"2002","journal-title":"Biochem. Biophy. Res. Commun."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1111\/j.1365-2672.2009.04174.x","article-title":"Antimicrobial activity of Coniothyrium minitans and its macrolide antibiotic macrosphelide A","volume":"106","author":"Tomprefa","year":"2009","journal-title":"J. Appl. Microbiol."},{"key":"ref_15","unstructured":"Omura, S., and Komiyama, K. (2001). Immunosuppressant macrosphelide B. WO0147516 A1."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"15982","DOI":"10.3390\/molecules191015982","article-title":"Synthetic Advance in Macrosphelides: Natural Anticancer Agents","volume":"19","author":"Paek","year":"2014","journal-title":"Molecules"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3987\/REV-09-660","article-title":"Artificial macrosphelides as a novel apoptosis-inducing compound","volume":"81","author":"Matsuya","year":"2010","journal-title":"Heterocycles"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.1016\/j.tet.2005.02.022","article-title":"Absolute stereochemistries and total synthesis of (+)\/(\u2212)-macrosphelides, potent, orally bioavailable inhibitors of cell\u2013cell adhesion","volume":"61","author":"Sunazuka","year":"2005","journal-title":"Tetrahedron"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.1002\/anie.200352229","article-title":"A combinatorial synthesis of a macrosphelide library utilizing a palladium-catalyzed carbonylation on a polymer support","volume":"42","author":"Takahashi","year":"2003","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"8857","DOI":"10.1016\/j.tetlet.2003.09.186","article-title":"Total synthesis of macrosphelide A by way of palladium-catalyzed carbonylative esterification","volume":"44","author":"Kusaka","year":"2003","journal-title":"Tetrahedron Lett."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1248\/cpb.50.692","article-title":"Formal total synthesis of (+)-macrosphelide A based on regioselective hydrolysis using lipase","volume":"50","author":"Ono","year":"2002","journal-title":"Chem. Pharm. Bull."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Ishihara, K., Kawaguchi, T., Matsuya, Y., Sakurai, H., Saiki, I., and Nemoto, H. (2004). Synthesis and biological evaluation of macrosphelide cores. Eur. J. Org. Chem., 3973\u20133978.","DOI":"10.1002\/ejoc.200400338"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.cbi.2007.07.007","article-title":"Rapid and transient intracellular oxidative stress due to novel macrosphelides trigger apoptosis via Fas\/caspase-8-dependent pathway in human lymphoma U937 cells","volume":"170","author":"Ahmed","year":"2007","journal-title":"Chem.-Biol. Interact."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/02656730701299682","article-title":"Enhancement of macrosphelide-induced apoptosis by mild hyperthermia","volume":"23","author":"Ahmed","year":"2007","journal-title":"Int. J. Hyperthermia"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3987\/COM-03-S26","article-title":"Synthesis of various macrosphelides by oxidative derivatization of the macrosphelide core","volume":"61","author":"Matsuya","year":"2003","journal-title":"Heterocycles"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1021\/ol061922v","article-title":"Synthesis of Macrosphelides with a Thiazole Side Chain: New Antitumor Candidates Having Apoptosis-Inducing Property","volume":"8","author":"Matsuya","year":"2006","journal-title":"Org. Lett."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1002\/anie.199615671","article-title":"Epothilone A and B-Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution","volume":"35","author":"Bedorf","year":"1996","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"10073","DOI":"10.1021\/ja971946k","article-title":"Total syntheses of epothilones A and B","volume":"119","author":"Meng","year":"1997","journal-title":"J. Am. Chem. Soc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1021\/ol0350689","article-title":"New strategy for the total synthesis of macrosphelides A and B based on ring-closing metathesis","volume":"5","author":"Matsuya","year":"2003","journal-title":"Org. Lett."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1021\/jo035435u","article-title":"Total Synthesis of Macrosphelides A, B, and E: First Application of Ring-Closing Metathesis for Macrosphelide Synthesis","volume":"69","author":"Kawaguchi","year":"2004","journal-title":"J. Org. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.cbi.2008.10.030","article-title":"Mechanism of apoptosis induced by a newly synthesized derivative of macrosphelides with a thiazole side chain","volume":"177","author":"Ahmed","year":"2009","journal-title":"Chem.-Biol. Interact."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1021\/np060344o","article-title":"Indole alkaloids from three species of the Ervatamia genus: E. officinalis, E. divaricata, and E. divaricata Gouyahua","volume":"70","author":"Zhang","year":"2007","journal-title":"J. Nat. Prod."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"12671","DOI":"10.1016\/j.tet.2007.10.019","article-title":"Total synthesis of trifluoromethylated analogs of macrosphelide A","volume":"63","author":"Wang","year":"2007","journal-title":"Tetrahedron"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0022-1139(01)00375-X","article-title":"Fluorine substituent effects (on bioactivity)","volume":"109","author":"Smart","year":"2001","journal-title":"J. Fluor. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"7544","DOI":"10.1021\/jo0344384","article-title":"Qing Asymmetric Synthesis of Both Enantiomers of anti-4,4,4-Trifluorothreonine and 2-Amino-4,4,4-trifluorobutanoic Acid","volume":"68","author":"Jiang","year":"2003","journal-title":"J. Org. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3987\/COM-08-S(F)47","article-title":"Total synthesis of 2-nor-macrosphelides A and B","volume":"77","author":"Matsuya","year":"2009","journal-title":"Heterocycles"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5799","DOI":"10.1002\/chem.200802661","article-title":"Design, Synthesis, and Biological Evaluation of Artificial Macrosphelides in the Search for New Apoptosis-Inducing Agents","volume":"15","author":"Matsuya","year":"2009","journal-title":"Chem. Eur. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3987\/COM-09-S(S)82","article-title":"Synthesis of macrosphelides containing a heterocyclic side chain as a novel apoptosis inducer","volume":"80","author":"Matsuya","year":"2010","journal-title":"Heterocycles"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"7681","DOI":"10.1016\/j.tet.2011.08.014","article-title":"Syntheses of aza-analogues of macrosphelides via RCM strategy and their biological evaluation","volume":"67","author":"Sugimoto","year":"2011","journal-title":"Tetrahedron"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Rae, A., Aliev, A.E., Anderson, J.E., Castro, J., Ker, J., Parsons, S., Stchedroff, M., Thomas, S., and Tabor, A. (1999). Preparation and structure of homochiral tetrahydro-2 H-1, 3-oxazines. J. Chem. Soc. Perkin Trans. 1, 1933\u20131942.","DOI":"10.1039\/a902667c"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.3987\/COM-11-12357","article-title":"Dihydroazamacrosphelides: Synthesis and apoptosis inducing activities","volume":"83","author":"Sugimoto","year":"2011","journal-title":"Heterocycles"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nchem.1233","article-title":"Binary fluorous tagging enables the synthesis and separation of a 16-stereoisomer library of macrosphelides","volume":"4","author":"Curran","year":"2012","journal-title":"Nat. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1021\/ol0508429","article-title":"Concise Syntheses of (+)-Macrosphelide A and B","volume":"7","author":"Paek","year":"2005","journal-title":"Org. Lett."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"7127","DOI":"10.1039\/C4OB01028K","article-title":"Design and synthesis of a macrosphelide A-biotin chimera","volume":"12","author":"Yun","year":"2014","journal-title":"Org. Biomol. 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