{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T15:56:05Z","timestamp":1769874965519,"version":"3.49.0"},"reference-count":35,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T00:00:00Z","timestamp":1426464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The composition of the essential oil from leaves of Skimmia laureola was determined by GC and GC-MS. Twenty-eight components were identified, accounting for 93.9% of the total oil. The oil is mainly composed of monoterpenes (93.5%), of which monoterpene hydrocarbons and oxygenated monoterpenes represent 11.0% and 82.5%, respectively. Sesquiterpenes constitute only 0.3% of the total oil. Linalyl acetate is the main component (50.5%), with linalool (13.1%), geranyl acetate (8.5%) and cis-p-menth-2-en-1-ol (6.2%) as other principal constituents. The essential oil showed a significant antispasmodic activity, in a dose range of 0.03\u201310 mg\/mL. The essential oil also possesses antibacterial and antifungal activities against some pathogenic strains. The phytotoxic and cytotoxic activities were also assessed.<\/jats:p>","DOI":"10.3390\/molecules20034735","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T11:17:39Z","timestamp":1426504659000},"page":"4735-4745","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Chemical Composition and Biological Activities of the Essential Oil of Skimmia laureola Leaves"],"prefix":"10.3390","volume":"20","author":[{"family":"Barkatullah","sequence":"first","affiliation":[{"name":"Department of Botany, University of Peshawar, Peshawar 25000, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Ibrar","sequence":"additional","affiliation":[{"name":"Department of Botany, University of Peshawar, Peshawar 25000, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveed","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1070-3207","authenticated-orcid":false,"given":"Vincenzo","family":"De Feo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Salerno, Fisciano 84084, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,3,16]]},"reference":[{"key":"ref_1","first-page":"636","article-title":"Traditional uses of some medicinal plants of Swat Valley, Pakistan","volume":"6","author":"Hamayun","year":"2007","journal-title":"Indian J. 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