{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:46:26Z","timestamp":1790124386705,"version":"4.0.1"},"reference-count":100,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T00:00:00Z","timestamp":1427414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Tetrazoles represent a class of five-membered heterocyclic compounds with polynitrogen electron-rich planar structural features. This special structure makes tetrazole derivatives useful drugs, explosives, and other functional materials with a wide range of applications in many fields of medicine, agriculture, material science, etc. Based on our research works on azoles and other references in recent years, this review covers reported work on the synthesis and biological activities of tetrazole derivatives.<\/jats:p>","DOI":"10.3390\/molecules20045528","type":"journal-article","created":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T17:12:08Z","timestamp":1427476328000},"page":"5528-5553","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":196,"title":["Tetrazolium Compounds: Synthesis and Applications in Medicine"],"prefix":"10.3390","volume":"20","author":[{"given":"Cheng-Xi","family":"Wei","sequence":"first","affiliation":[{"name":"Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao 028000, Inner Mongolia, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Bian","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao 028000, Inner Mongolia, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Hua","family":"Gong","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao 028000, Inner Mongolia, China"},{"name":"Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao 028000,  Inner Mongolia, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,3,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1021\/ic50094a011","article-title":"Platinum- and palladium-tetrazole complexes","volume":"9","author":"Jonassen","year":"1970","journal-title":"Inorg. 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