{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T04:55:16Z","timestamp":1764046516810,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T00:00:00Z","timestamp":1430265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"King Abdulaziz City for Science and Technology (KACST)","award":["11-BIO2138-04"],"award-info":[{"award-number":["11-BIO2138-04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Two new DTPA-bis(amide) based ligands conjugated with the arylpiperazinyl moiety were synthesized and subsequently transformed into their corresponding Gd(III) complexes 1 and 2 of the type [Gd(L)H2O]\u00b7nH2O. The relaxivity (R1) of these complexes was measured, which turned out to be comparable with that of Omniscan\u00ae, a commercially available MRI contrast agent. The cytotoxicity studies of these complexes indicated that they are non-toxic, which reveals their potential and physiological suitability as MRI contrast agents. All the synthesized ligands and complexes were characterized with the aid of analytical and spectroscopic methods, including elemental analysis, 1H-NMR, FT-IR, XPS and fast atom bombardment (FAB) mass spectrometry.<\/jats:p>","DOI":"10.3390\/molecules20057807","type":"journal-article","created":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T11:02:35Z","timestamp":1430305355000},"page":"7807-7819","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Gd-Complexes of New Arylpiperazinyl Conjugates of  DTPA-Bis(amides): Synthesis, Characterization and  Magnetic Relaxation Properties"],"prefix":"10.3390","volume":"20","author":[{"given":"Abdullah","family":"Ba-Salem","sequence":"first","affiliation":[{"name":"Chemistry Department, King Fahd University of Petroleum and Minerals, Dhahran-31261,  Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisar","family":"Ullah","sequence":"additional","affiliation":[{"name":"Chemistry Department, King Fahd University of Petroleum and Minerals, Dhahran-31261,  Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Center of Research Excellence in Nanotechnology, King Fahd University of Petroleum and Minerals, Dhahran-31261, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Faiz","sequence":"additional","affiliation":[{"name":"Physics Department, King Fahd University of Petroleum and Minerals, Dhahran-31261,  Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8530-8711","authenticated-orcid":false,"given":"Zaheer","family":"Ul-Haq","sequence":"additional","affiliation":[{"name":"Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/242190a0","article-title":"Image formation by induced local interactions: Examples employing nuclear magnetic resonance","volume":"242","author":"Lauterbur","year":"1973","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1021\/cr980440x","article-title":"Gadolinium(III) chelates as MRI contrast agents: Structure, dynamics, and applications","volume":"99","author":"Caravan","year":"1999","journal-title":"Chem. 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