{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:35:01Z","timestamp":1790184901345,"version":"4.1.0"},"reference-count":170,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T00:00:00Z","timestamp":1431993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Lichens are a form of symbiont between a fungus and an alga or cyanobacterium, which contains a wide variety of organic compounds with certain secondary metabolite classes typical of these organisms. The Ramalina genus has approximately 246 species distributed around the World, of which in this review approximately 118 species with published chemical or biological activity studies of extracts or isolated compounds were cited. From the 153 mentioned compounds, only 27 passed were tested for biological activity, being usnic acid the most studied compound and the one showing the best results in almost all in vitro tests performed, although other compounds also presented excellent results as antimicrobial, antitumor and  anti-inflammatory agents, among others. Extracts of several species also presented significant results in performed biological tests, demonstrating the potential that these organisms have, in particular, the gender Ramalina, to produce bioactive molecules that can be used as a model for the production of pharmaceuticals.<\/jats:p>","DOI":"10.3390\/molecules20058952","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T10:35:57Z","timestamp":1432031757000},"page":"8952-8987","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Chemistry and Biological Activity of Ramalina Lichenized Fungi"],"prefix":"10.3390","volume":"20","author":[{"given":"Ant\u00f4nio","family":"Moreira","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Ci\u00eancias Qu\u00edmicas, Universidade Estadual do Norte Fluminense Darcy Ribeiro, UENF, Avenida Alberto Lamego 2000, Campos dos Goytacazes, 28013-602 Rio de Janeiro, Brazil"},{"name":"Instituto Federal Fluminense, IFF, Avenida Souza Mota 350, Parque Fund\u00e3o,  Campos dos Goytacazes, 28060-010 Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimundo","family":"Braz-Filho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Ci\u00eancias Qu\u00edmicas, Universidade Estadual do Norte Fluminense Darcy Ribeiro, UENF, Avenida Alberto Lamego 2000, Campos dos Goytacazes, 28013-602 Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Mussi-Dias","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Entomologia e Fitopatologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, UENF, Avenida Alberto Lamego 2000, Campos dos Goytacazes, 28013-602 Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Vieira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Ci\u00eancias Qu\u00edmicas, Universidade Estadual do Norte Fluminense Darcy Ribeiro, UENF, Avenida Alberto Lamego 2000, Campos dos Goytacazes, 28013-602 Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,5,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Huneck, S., and Yoshimura, I. (1996). Identification of Lichen Substances, Springer-Verlag.","DOI":"10.1007\/978-3-642-85243-5"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1079\/PGR200572","article-title":"Lichens\u2014A promising source of bioactive secondary metabolites","volume":"3","author":"Boustie","year":"2005","journal-title":"Plant Genet. Resour."},{"key":"ref_3","first-page":"110","article-title":"A qu\u00edmica dos liquens","volume":"21","author":"Honda","year":"1998","journal-title":"Quim. Nova"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0021-9673(93)83356-W","article-title":"Identification of lichen substances by a standardized high-performance liquid chromatographic method","volume":"647","author":"Feige","year":"1993","journal-title":"J. Chromatogr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.phytochem.2013.02.002","article-title":"Comparative metabolite profiling and chemical study of Ramalina siliquosa complex using LC-ESI-MS\/MS approach","volume":"89","author":"Parrot","year":"2013","journal-title":"Phytochemistry"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s00253-006-0611-3","article-title":"Ecological and biotechnological aspects of lichens","volume":"73","author":"Oksanen","year":"2006","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_7","unstructured":"Kirk, P.M., Cannon, P.F., Minter, D.W., and Stalpers, J.A. (2008). Dictionary of the Fungi, CABI\u2014Europe-UK, Cromwell Press."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s10529-009-0191-2","article-title":"Human dermal fibroblast proliferation activity of usimine-C from Antarctic lichen Ramalina terebrata","volume":"32","author":"Lee","year":"2010","journal-title":"Biotechnol. Lett."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.phymed.2011.06.007","article-title":"Ramalin, a novel nontoxic antioxidant compound from the Antarctic lichen Ramalina terebrata","volume":"18","author":"Paudel","year":"2011","journal-title":"Phytomedicine"},{"key":"ref_10","unstructured":"Yim, J.H., Lee, H.K., Bhattarai, H.D., Babita, P., Kim, I.C., Hong, S.G., Kim, D.K., Lee, Y.K., Gu, S., and Oh, H.C. (2010). Antioxidant Activities of Ramalin Isolated from Ramalina terebrata Extracts. (WO 2,010,053,327 A2)."},{"key":"ref_11","unstructured":"Yim, J.H., Kim, I.C., Lee, S.G., Kim, D.K., Han, S.J., Lee, H.S., Seok, K.H., Kim, S.J., Kim, T.K., and Kang, P.S. (2011). Pharmaceutical Composition for the Treatment of Inflammatory Disease or Immune Disease Containing Ramalin. (WO 2,011,152,671 A2)."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1055\/s-2006-961433","article-title":"Chemical constituents of the lichen Ramalina hierrensis","volume":"58","author":"Gonzalez","year":"1992","journal-title":"Planta Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/cber.19320650415","article-title":"Lichen substances.III. Constitution of obtusatic acid","volume":"65B","author":"Asahina","year":"1932","journal-title":"Ber. Dtsch. Chem. Ges. B"},{"key":"ref_14","first-page":"1391","article-title":"Galactomannan and isolichenan componentes of the carbohydrate-rich lichen Ramalina ecklonii (Spreng.) Mey. & Flot","volume":"55","author":"Miceno","year":"1991","journal-title":"Agric. Biol. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1016\/0031-9422(92)83708-7","article-title":"An unusual glucomannan from Tornabenia intricata","volume":"31","author":"Teixeira","year":"1992","journal-title":"Phytochemistry"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0144-8617(99)00048-X","article-title":"The glucans of Ramalina celastri; relation with chemotypes of other lichens","volume":"40","author":"Stuelp","year":"1999","journal-title":"Carbohydr. Polym."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0378-1097(03)00066-1","article-title":"Linear \u03b2-mannose containig polysaccharide, \u03b2-xylan, and amylose from the cultured photobiont Trebouxia sp. of the ascolichen Ramalina celastri","volume":"220","author":"Cordeiro","year":"2003","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S0031-9422(03)00336-4","article-title":"Comparative studies of the polysaccharides from species of the genus Ramalina-lichenized fungi-of three distinct habitats","volume":"63","author":"Cordeiro","year":"2003","journal-title":"Phytochemistry"},{"key":"ref_19","first-page":"79","article-title":"Elucidation of polysaccharide origin in Ramalina peruviana symbiosis","volume":"238","author":"Cordeiro","year":"2004","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.femsle.2005.01.040","article-title":"A fungus-type \u03b2-galactofuranan in the cultivated Trebouxia photobiont of the lichen Ramalina gracilis","volume":"244","author":"Cordeiro","year":"2005","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0008-6215(84)85090-9","article-title":"Polysaccharides of the lichens Cetraria islandica and Ramalina usnea","volume":"128","author":"Gorin","year":"1984","journal-title":"Carbohydr. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1248\/cpb.27.238","article-title":"Polysaccharides of lichen symbionts","volume":"27","author":"Takahashi","year":"1979","journal-title":"Chem. Pharm. Bull."},{"key":"ref_23","first-page":"209","article-title":"Analysis monosaccharide of the polysaccharide in Ramalina sinensis with HPLC","volume":"34","author":"Mamut","year":"2013","journal-title":"Shipin Gongye"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1093\/pcp\/pct079","article-title":"Arabitol provided by lichenous fungi enhances ability to dissipate excess light energy in a symbiotic green alga under desiccation","volume":"54","author":"Kosugi","year":"2013","journal-title":"Plant Cell Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.5586\/asbp.1979.002","article-title":"Chemical composition of Ramalina fraxinea (L.) Ach. Thallus","volume":"48","author":"Krzacek","year":"1979","journal-title":"Acta Soc. Bot. Pol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1021\/ja01160a118","article-title":"Method of isolation of usnic acid from Ramalina reticulata","volume":"72","author":"Stark","year":"1950","journal-title":"J. Am. Chem. Soc."},{"key":"ref_27","first-page":"386","article-title":"Chemical investigation of Indian lichens. XIV. Chemical components of Ramalina calicaris and Ramalina sinensis","volume":"11B","author":"Mittal","year":"1952","journal-title":"J. Sci. Ind. Res. India"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0031-9422(00)86273-1","article-title":"Some constituents of the lichen Ramalina siliquosa","volume":"4","author":"Culberson","year":"1965","journal-title":"Phytochemistry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF03049170","article-title":"Indian lichens. VIII. Lichens growing on sandal trees","volume":"30A","author":"Seshadri","year":"1949","journal-title":"Proc.-Indian Acad. Sci. Sect. A"},{"key":"ref_30","first-page":"799","article-title":"Lichen substances. XXXIX. A new lichen acid, norstictinic acid, and the occurrence of d-arabitol in lichens","volume":"67B","author":"Ashina","year":"1934","journal-title":"Ber. Dtsch. Chem. Ges. B"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.ijbiomac.2008.02.002","article-title":"Galactofuranose-rich heteropolysaccharide from Trebouxia sp., photobiont of the lichen Ramalina gracilis and its effect on macrophage activation","volume":"42","author":"Cordeiro","year":"2008","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0008-6215(85)85027-8","article-title":"Structural diversity of d-galacto-d-mannan components isolated from lichens having ascomycetous mycobionts","volume":"142","author":"Gorin","year":"1985","journal-title":"Carbohydr. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0008-6215(94)00257-G","article-title":"Chemotypes of mannose-containing polysaccharides of lichens mycobionts: A possible aid in classification and identification","volume":"266","author":"Teixeira","year":"1995","journal-title":"Carbohydr. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S1567-5769(02)00003-6","article-title":"Effect of a soluble \u03b1-d-glucan from the lichenized fungus Ramalina celastri on macrophage activity","volume":"2","author":"Carbonero","year":"2002","journal-title":"Int. Immunopharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1574-6968.2011.02309.x","article-title":"Does apossymbiotically cultivated fungus Ramalina produce isolichenan?","volume":"321","author":"Cordeiro","year":"2011","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/BF00387655","article-title":"Occurrence of starch in Chlorophyceae phycobionts","volume":"93","author":"Peveling","year":"1970","journal-title":"Planta"},{"key":"ref_37","first-page":"25","article-title":"Polysaccharide composition of Ramalina terebrata","volume":"1","author":"McAvoy","year":"2012","journal-title":"Abstr. Pap. Am. Chem. Soc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0031-9422(00)97135-8","article-title":"Polyols produced by the cultured phyco- and mycobionts of some Ramalina species","volume":"10","author":"Komiya","year":"1971","journal-title":"Phytochemistry"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"333","DOI":"10.2307\/2805533","article-title":"Analysis of chemical and morphological variation in the Ramalina siliquosa species complex","volume":"19","author":"Culberson","year":"1967","journal-title":"Brittonia"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1016\/S0031-9422(00)82741-7","article-title":"L\u2019acide O-m\u00e9thyl-4\u2032 nors\u00e9kika\u00efque, nouveau metadepside isole d\u2019um lichen du genre Ramalina","volume":"18","author":"Molho","year":"1979","journal-title":"Phytochemistry"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1039\/jr9350001379","article-title":"Lichen acids. Part VI. Constituensts of Ramalina scopulorum","volume":"329","author":"Curd","year":"1935","journal-title":"J. Chem. Soc."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1515\/znc-2004-5-617","article-title":"Evaluation of the antimicrobial activity of the acetone extract of the lichen Ramalina farinacea and its (+)-usnic acid, norstitic acid, and protocetraric acid constituents","volume":"59","author":"Tay","year":"2004","journal-title":"Z. Naturforschung C"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1017\/S0024282972000349","article-title":"Typification of Ramalina usnea (L.) R. H. Howe","volume":"5","author":"Imshaug","year":"1972","journal-title":"Lichenologist"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.bse.2003.08.010","article-title":"Chemical study of Ramalina africana (Ramalinaceae) from the Garhwal Himalayas","volume":"32","author":"Shukla","year":"2004","journal-title":"Biochem. Syst. Ecol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0367-326X(99)00054-4","article-title":"Antimicrobial activity and cytotoxicity of Ramalina farinacea","volume":"70","author":"Esimone","year":"1999","journal-title":"Fitoterapia"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"203","DOI":"10.5507\/bp.2008.031","article-title":"Biodiversity of the chemical constituents in the epiphytic lichenized ascomycete Ramalina lacera grown on difference substrates Crataegus sinaicus, Pinus halepensis, and Quercus calliprinos","volume":"152","author":"Hanus","year":"2008","journal-title":"Biomed. Pap."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1078\/094471103322331458","article-title":"Cytotoxic activity of some lichen extracts on murine and human cancer cell lines","volume":"10","author":"Tomasi","year":"2003","journal-title":"Phytomedicine"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1515\/znc-2007-7-813","article-title":"Lichen secondary metabolites from the cultured lichen mycobionts of Teloschistes chrysophthalmus and Ramalina celastri and their antiviral activities","volume":"62","author":"Fazio","year":"2007","journal-title":"Z. Naturforschung C"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s10886-008-9584-2","article-title":"Lichen substances prevent lichens from nutrient deficiency","volume":"35","author":"Hauck","year":"2009","journal-title":"J. Chem. Ecol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.3891\/acta.chem.scand.10-1116","article-title":"Dyeing of wool with lichens and lichen substances","volume":"10","author":"Solberg","year":"1956","journal-title":"Acta Chem. Scand."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s12223-012-0100-2","article-title":"Studies on nutritional requirement for the culture of lichen Ramalina nervulosa and Ramalina pacifica to enhance the production of antioxidant metabolites","volume":"57","author":"Verma","year":"2012","journal-title":"Folia Microbiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/13880200601028503","article-title":"HPLC analysis of usnic acid in some Ramalina species from Anatolia and investigation of their antimicrobial activities","volume":"45","author":"Cansaran","year":"2007","journal-title":"Pharm. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0031-9422(02)00383-7","article-title":"Usnic acid","volume":"61","year":"2002","journal-title":"Phytochemistry"},{"key":"ref_54","first-page":"3347","article-title":"Tissue cultures of Usnea rubescens and Ramalina yasudae and production of usnic acid in their cultures","volume":"49","author":"Yamamoto","year":"1985","journal-title":"Agric. Biol. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0031-9422(00)85190-0","article-title":"Stenosporic acid, a new depside in Ramalina stenospora","volume":"9","author":"Culberson","year":"1970","journal-title":"Phytochemistry"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1248\/cpb.17.1305","article-title":"Formation of lichen substances by mycobionts of lichens. Isolation of (+)-usnic acid and salazinic acid from mybobionts of Ramalina sp","volume":"17","author":"Komiya","year":"1969","journal-title":"Chem. Pharm. Bull."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.3891\/acta.chem.scand.19-1185","article-title":"Studies on the chemistry of lichens","volume":"19","author":"Bendz","year":"1965","journal-title":"Acta Chem. Scand."},{"key":"ref_58","unstructured":"Urdapilleta, A.A.A. (2006). Atividade de Subst\u00e2ncias Isoladas de L\u00edquens Sobre Formas Promastigotas de Leishmania (L.) amazonensis e Leishmania (V.) braziliensis. [Master\u2019s Thesis, Universidade de Bras\u00edlia]."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1017\/S0024282907006901","article-title":"The lichen genus Ramalina on the Galapagos","volume":"39","author":"Aptroot","year":"2007","journal-title":"Lichenologist"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/lich.1993.1010","article-title":"The genus Ramalina in Brazil","volume":"25","author":"Kashiwadani","year":"1993","journal-title":"Lichenologist"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1017\/S0024282978000262","article-title":"Evolution relationships in the Ramalina usnea complex","volume":"10","author":"Rundel","year":"1978","journal-title":"Lichenologist"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1055\/s-0033-1350711","article-title":"Phenolic compounds with in vitro activity against respiratory syncytial from the Nigerian lichen Ramalina farinacea","volume":"79","author":"Lai","year":"2013","journal-title":"Planta Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1515\/znb-1966-0928","article-title":"Lichen constituents. XXXIV. Structure and composition of Ramalina boulhautiana","volume":"21","author":"Huneck","year":"1966","journal-title":"Z. Naturforschung B"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1515\/znb-1966-0131","article-title":"Lichen constituents. XX. Chemistry of Chilean lichens. 8. Componets of Ramalina chilensis","volume":"21","author":"Huneck","year":"1966","journal-title":"Z. Naturforschung B"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/cber.19330660106","article-title":"Lichen substances. XVI. Constituents of Ramalina species with special reference to sekikaic acid","volume":"66B","author":"Asahina","year":"1933","journal-title":"Ber. Dtsch. Chem. Ges. B"},{"key":"ref_66","first-page":"28","article-title":"Chemical constituents and antibacterial activity of Ramalina subcomplanata","volume":"14","author":"Kumar","year":"1995","journal-title":"J. Nepal Chem. Soc."},{"key":"ref_67","first-page":"252","article-title":"Components of Ramalina pollinaria","volume":"20","author":"Morozova","year":"1984","journal-title":"Khim. Prirod. Soed."},{"key":"ref_68","first-page":"517","article-title":"Chemical constituents of Umbilicaria indica Frey and Ramalina farinacea L. Ach","volume":"45","author":"Rao","year":"1976","journal-title":"Curr. Sci."},{"key":"ref_69","first-page":"807","article-title":"Chemical components of lichens. II. Ramalina tingitana","volume":"69","author":"Gonzalez","year":"1973","journal-title":"Anal. Quim."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1639\/0007-2745(1969)72[254:TTOLFL]2.0.CO;2","article-title":"Typification of lichen farinaceous","volume":"72","author":"Hawksworth","year":"1969","journal-title":"Bryologist"},{"key":"ref_71","first-page":"165","article-title":"Content of lichen substances in some species of Ramalina","volume":"22","author":"Popiolek","year":"1967","journal-title":"Ann. Univ. Mariae Curie\u2013Sklodowska Sect. C"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1639\/0007-2745(1967)70[397:TCCORP]2.0.CO;2","article-title":"Chemical constituents of Ramalina paludosa","volume":"70","author":"Culberson","year":"1967","journal-title":"Bryologist"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1515\/znb-1967-0131","article-title":"Lichen constituents. XXXVI. Chemistry of Chilean lichens. 15. Constituents of Ramalina cactacearum, var. ambigua, and Medusulina chilena","volume":"22","author":"Huneck","year":"1967","journal-title":"Z. Naturforschung B"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF00625475","article-title":"The presence of usnic acid in Lecanora melanophthalma and Ramalina terebrata","volume":"51","author":"Huneck","year":"1964","journal-title":"Naturwissenschaften"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1071\/CH9600277","article-title":"Chemistry of Australian lichens. I. Some constituents of Parmelia conspersa, Ramalina fraxinea, Usnea barbata, and Usnea ceratina from the New England region","volume":"13","author":"Briner","year":"1960","journal-title":"Aust. J. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1002\/cber.19370700828","article-title":"Lichen substances. LXXXIII. A new depside, boninic acid; synthesis of boninic acid and of homosekikaic acid","volume":"70B","author":"Asahina","year":"1937","journal-title":"Ber. Dtsch. Chem. Ges. B"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1248\/yakushi1881.1923.496_423","article-title":"Chemical constituents of a Chinese drug \u201cshi-hoa\u201d and their constitutions","volume":"496","author":"Nakao","year":"1923","journal-title":"Yakugaku Zasshi"},{"key":"ref_78","first-page":"91","article-title":"Tinctorial constituents of some lichens, which are used as dyes in Irland","volume":"33","author":"Ryan","year":"1917","journal-title":"Proc. R. Irish Acad. B"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/jlac.19103770106","article-title":"Circular polarization of usninic acids and other lichen substances","volume":"377","author":"Salkowski","year":"1911","journal-title":"Liebigs Ann. Chem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jlac.19073520102","article-title":"A contribution to the knowledge of the lichen constituents","volume":"352","author":"Zopf","year":"1907","journal-title":"Liebigs Ann. Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/jlac.18972970303","article-title":"To the knowledge of the lichen material","volume":"297","author":"Zopf","year":"1897","journal-title":"Liebigs Ann."},{"key":"ref_82","first-page":"150","article-title":"Content determination and antioxidant activity evaluation of usnic acid in Ramalina sinensis Jatta","volume":"31","author":"Tugunay","year":"2010","journal-title":"Shipin Kexue"},{"key":"ref_83","first-page":"130","article-title":"Usnic acid and atranorin in some regional lichens","volume":"12","author":"Reyes","year":"1981","journal-title":"Rev. Latinoam. Quim."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1017\/S0024282961000498","article-title":"The Genus Ramalina in the British Isles","volume":"5","author":"Wade","year":"1961","journal-title":"Lichenologist"},{"key":"ref_85","unstructured":"Marshak, A.G. (1951). Extracting Usnic Acid. (US 2,557,987 A)."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/jlac.19053400303","article-title":"To the knowledge of the lichen substances","volume":"340","author":"Zopf","year":"1905","journal-title":"Liebigs Ann. Chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1017\/S0953756204009402","article-title":"Culture studies and secondary compounds of six Ramalina species","volume":"108","author":"Cordeiro","year":"2004","journal-title":"Mycol. Res."},{"key":"ref_88","unstructured":"Asahina, Y., and Shibata, S. (1971). Chemistry of Lichen Substances, A, Asher & Co. Ltd."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2307\/3242622","article-title":"Individual variation in the contents of lichen substances in Ramalina nervulosa and Ramalina subcomplanata","volume":"91","author":"Hamada","year":"1988","journal-title":"Bryologist"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"396","DOI":"10.2307\/3242860","article-title":"A chemically distinctive new Ramalina from Fiji","volume":"84","author":"Molho","year":"1981","journal-title":"Bryologist"},{"key":"ref_91","first-page":"197","article-title":"Chemical components of Ramalina farinacea","volume":"16","author":"Rangaswami","year":"1954","journal-title":"Indian J. Pharm."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1080\/14786419.2013.811410","article-title":"Antibacterial and antioxidante activity of lichen species Ramalina roesleri","volume":"27","author":"Sisodia","year":"2013","journal-title":"Nat. Prod. Res."},{"key":"ref_93","first-page":"309","article-title":"Studies on chemical composition and in vitro antibacterial activity of solvent extracts of the lichen Ramalina hossei Vain","volume":"3","author":"Vinayaka","year":"2009","journal-title":"BioTechnol. Indian J."},{"key":"ref_94","first-page":"238","article-title":"Anthelmintic and antioxidant efficacy of two macrolichens of Ramalinaceae","volume":"1","author":"Kekuda","year":"2009","journal-title":"Pharmacogn. J."},{"key":"ref_95","first-page":"959","article-title":"Phytochemical investigation of the Australian lichens Ramalina glaucescens and Xanthoria parietina","volume":"4","author":"Dias","year":"2009","journal-title":"Nat. Prod. Commun."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/S10267-010-0048-5","article-title":"Antioxidant activities of edible lichen Ramalina conduplicans and its free radical scavenging constituents","volume":"51","author":"Luo","year":"2010","journal-title":"Mycoscience"},{"key":"ref_97","first-page":"445","article-title":"Chemical investigation of south Indian lichens: Ramalina species","volume":"31","author":"Ramesh","year":"1994","journal-title":"Indian Drugs"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF02491097","article-title":"The effect of temperature on lichen substances in Ramalina subbreviuscula (Lichens)","volume":"96","author":"Hamada","year":"1983","journal-title":"Bot. Mag."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/cber.19360690245","article-title":"Lichen substances. LXV. A new depside, ramalinolic acid","volume":"69B","author":"Asahina","year":"1936","journal-title":"Ber. Dtsch. Chem. Ges. B"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/S0031-9422(00)90110-9","article-title":"Lichen constituents. LXXXIX. Secondary substances of some lichens","volume":"11","author":"Huneck","year":"1972","journal-title":"Phytochemistry"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1002\/cber.19660990404","article-title":"Lichen constituents. XXXIV. Structure of tumidulin, a new chlorine containing depside","volume":"99","author":"Huneck","year":"1966","journal-title":"Chem. Ber."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.3891\/acta.chem.scand.19-1188","article-title":"Chemistry of lichens. XXI. Isolation and synthesis of methyl 3,5-dichlorolecanorate, a new depside from Ramalina spp","volume":"19","author":"Bendz","year":"1965","journal-title":"Acta Chem. Scand."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/BF01552779","article-title":"Ramalic acid","volume":"61","author":"Koller","year":"1932","journal-title":"Monatsh. Chem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1071\/CH9782745","article-title":"The identification of four new meta-depsides in the lichen Ramalina asahinae","volume":"31","author":"Chester","year":"1978","journal-title":"Aust. J. Chem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1007\/s10886-007-9330-1","article-title":"Ozone Reactivity and Free Radical Scavenging Behavior of Phenolic Secondary Metabolites in Lichens Exposed to Chronic Oxidant Air Pollution from Mexico City","volume":"33","author":"Islas","year":"2007","journal-title":"J. Chem. Ecol."},{"key":"ref_106","first-page":"1705","article-title":"Depside from an isolated lichen mycobiont","volume":"51","author":"Hamada","year":"1987","journal-title":"Agric. Biol. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1515\/znb-1968-0617","article-title":"Lichen components. XLIX. 4-O-demethylbarbatinic acid, a new depside from Ramalina subdecipiens","volume":"23","author":"Huneck","year":"1968","journal-title":"Z. Naturforschung B"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/prac.19030680101","article-title":"Contribution for the knowledge of the lichens and their characteristic components","volume":"68","author":"Hesse","year":"1903","journal-title":"J. Prakt. Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"595","DOI":"10.2307\/3244249","article-title":"Trivaric acid, a new tridepside in the Ramalina americana chemotype complex (lichenized Ascomycota: Ramalinaceae)","volume":"102","author":"Culberson","year":"2000","journal-title":"Bryologist"},{"key":"ref_110","first-page":"407","article-title":"Peculiarities of the Australiasian lichen flora: Accessory metabolites, chemical and hybrid strains","volume":"52","author":"Elix","year":"1982","journal-title":"J. Hattori Bot. Lab."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2307\/3243623","article-title":"A novel meta-depside from the Ramalina subfraxinea complex (Ascomycotina, Ramalinaceae)","volume":"93","author":"Culberson","year":"1990","journal-title":"Bryologist"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/S0040-4039(01)96014-9","article-title":"Desmaziera evernioides and Ramalina bourgeana","volume":"18","author":"Bodo","year":"1973","journal-title":"Tetraedron Lett."},{"key":"ref_113","first-page":"23","article-title":"Bourgeanic acid: A new metabolite of lichens. Structure, synthesis and biosynthesis","volume":"3","author":"Bodo","year":"1975","journal-title":"Bull. Mus. Natl. Hist. Nat. Sci. Phys.-Chim."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1126\/science.106.2756.394","article-title":"Antibiotic compound isolated from the lichen Ramalina reticulate","volume":"24","author":"Marshak","year":"1947","journal-title":"Science"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1639\/0007-2745(2004)107[0152:SCOLFC]2.0.CO;2","article-title":"Secondary chemistry of lichen forming fungi: Chemosyndromic variation and DNA analyses of cultures and chemotypes in the Ramalina farinacea","volume":"107","author":"Elix","year":"2004","journal-title":"Bryologist"},{"key":"ref_116","first-page":"317","article-title":"Chemical strains of the lichen Ramalina subfariancacea","volume":"121","author":"Hawksworth","year":"1968","journal-title":"Bot. Notiser"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1639\/0007-2745(1965)68[301:SMTFTL]2.0.CO;2","article-title":"Microchemical tests for the lichen depsidone hypoprotocetraric acid","volume":"68","author":"Culberson","year":"1965","journal-title":"Bryologist"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1515\/znb-1966-0327","article-title":"Lichen constituents. XXVII. Identity between coquimboic acid and hypoprotocetraric acid","volume":"21","author":"Huneck","year":"1966","journal-title":"Z. Naturforschung B"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2323\/jgam.20.83","article-title":"Fatty acid composition of lichens and their phyco and mycobionts","volume":"20","author":"Yamamoto","year":"1974","journal-title":"J. Gen. Appl. Microbiol."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Blunt, J.W., and Munro, M.H.G. (2008). Dictionary of Marine Natural Products, Chapman & Hall\u2013Taylor & Francis Group.","DOI":"10.1201\/9780849382178"},{"key":"ref_121","first-page":"213","article-title":"Usnic acid and triacylglycerides production by the cultured lichen mycobiont of Ramalina celastri","volume":"9","author":"Fazio","year":"2014","journal-title":"Nat. Prod. Commun."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1248\/yakushi1947.100.7_755","article-title":"Anti-tumor activities of some lichen products and their degradation products","volume":"100","author":"Hirayama","year":"1980","journal-title":"Yakugaku Zasshi"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0305-1978(87)90097-4","article-title":"Carotenoids in lichens from Argentina","volume":"15","author":"Czeczuga","year":"1987","journal-title":"Biochem. Syst. Ecol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0163-7827(92)90002-Z","article-title":"Lipids of lichens","volume":"31","author":"Dembitsky","year":"1992","journal-title":"Prog. Lipid Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1515\/znb-1966-0727","article-title":"Lichen constituents. XXVIII. Chemistry of Chilean lichen. Compounds from Ramalina tigrina, and Ramalina inanis","volume":"21","author":"Huneck","year":"1966","journal-title":"Z. Naturforschung B"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1515\/znb-1965-1021","article-title":"Lichen constituents. XVIII. First separation of the diterpene (\u2212)-16-\u03b1-hydroxykaurane from a lichen","volume":"20","author":"Lehn","year":"1965","journal-title":"Z. Naturforschung B"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11745-001-0703-y","article-title":"Fatty acid composition of lipids present in selected lichenized fungi: A chemotyping study","volume":"36","author":"Sassaki","year":"2001","journal-title":"Lipids"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0031-9422(96)00876-X","article-title":"A galactosphingolipid from the lichen, Ramalina celastri","volume":"45","author":"Machado","year":"1997","journal-title":"Phytochemistry"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1134\/S1021443708010147","article-title":"Abscisic acid and polyamine contents in the lichens Pseudevernia furfuracea and Ramalina farinacea. A. Sukatar","volume":"55","author":"Unal","year":"2008","journal-title":"Russ. J. Plant Physiol."},{"key":"ref_130","unstructured":"Mateos, J.L., and Legaz, M.E. (1997). Eukaryotism and Symbiosis, Springer-Verlag."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1017\/S0024282970000361","article-title":"Studies on the chemistry of lichens. IX Quantitative determination of monosaccharides and amino acids in hydrolysates of several Norwegian lichen species","volume":"4","author":"Solberg","year":"1970","journal-title":"Lichenologist"},{"key":"ref_132","first-page":"124","article-title":"Amino acids of Lobaria subisidiosa, Umbilicaria pustulata, Parmelia nepalensis, and Ramalina sinensis","volume":"35","author":"Ramakrishnan","year":"1966","journal-title":"Curr. Sci. Indian"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1248\/yakushi1947.92.7_823","article-title":"Free amino acids in lichens of Japan","volume":"92","author":"Fujikawa","year":"1972","journal-title":"Yakugaku Zasshi"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1515\/znc-2010-1-206","article-title":"Antibacterial activities of ramalin, usnic acid and its tree derivatives isolated from the Antarctic lichen Ramalina terebrata","volume":"65","author":"Paudel","year":"2010","journal-title":"Z. Naturforschung C"},{"key":"ref_135","unstructured":"Yim, J.H., Kim, I.C., Han, S.J., Lee, H.S., Battarai, H.D., Yang, S-G., and Lee, D.H. (2013). Ramalin for Preveting or Treating Hepatic Fibrosis and Liver Cirrhosis. (WO 2,013,129,714 A1)."},{"key":"ref_136","unstructured":"Yim, J.H., Kim, I.C., Lee, S.G., Kim, D.G., Han, S.J., Lee, H.S., Kim, S.J., Kim, T.G., Kang, P.S., and Park, H.Y. (2013). Ramalin for Preveting and Treating Inflammatory Diseases and Immune Diseases. (KR 1290745 B1)."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.tetlet.2007.11.022","article-title":"Stereocalpin A, a bioactive cyclic depsipeptide from the Antarctic lichen Stereocaulon alpinum","volume":"49","author":"Seo","year":"2008","journal-title":"Tetrahedron Lett."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.intimp.2011.11.020","article-title":"Stereocalpin A inhibits the expression of adhesion molecules in activated vascular smooth muscle cells","volume":"12","author":"Byeon","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"ref_139","unstructured":"Yim, J.H., Kim, I.C., Kim, D.G., Han, S.J., Lee, H.S., Oh, H.C., and Pyo, S.N. (2013). Stereoclapin-A for Preveting or Treating Arteriosclerosis. (KR 20,130,043,995 A)."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/hlca.192801101102","article-title":"Constituents of lichens. II. Constitution of barbatinic acid","volume":"11","author":"Pfau","year":"1928","journal-title":"Helv. Chim Acta"},{"key":"ref_141","first-page":"27","article-title":"The constituents of absolute from Ramalina fastigiata (Pors) Ach. The main ethyl ester of fatty acids","volume":"1","author":"Huang","year":"1989","journal-title":"Nat. Prod. Res. Dev."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/0031-9422(93)85158-N","article-title":"Alkanes in lichens","volume":"32","author":"Zygadlo","year":"1993","journal-title":"Phytochemistry"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0305-1978(78)90002-9","article-title":"The ecological role of secondary lichen substances","volume":"6","author":"Rundel","year":"1978","journal-title":"Biochem. Syst. Ecol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.phymed.2005.09.008","article-title":"Screening the antioxidant and antimicrobial properties of the lichens Parmelia saxatilis, Platismatia glauca, Ramalina pollinaria, Ramalina polymorpha and Umbilicaria nylanderiana","volume":"13","author":"Gulluce","year":"2006","journal-title":"Phytomedicine"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1002\/ptr.2445","article-title":"Antibacterial potential of Antarctic lichens against human pathogenic Gram-positive bacteria","volume":"22","author":"Paudel","year":"2008","journal-title":"Phytother. Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10750-006-0220-2","article-title":"The study of antagonistic interactions among pelagic bacteria: A promising way to coin environmentally friendly antiflouling compounds","volume":"568","author":"Bhattarai","year":"2006","journal-title":"Hydrobiologia"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1128\/AAC.22.2.186","article-title":"Rapidly growing mycobacteria: Testing of susceptibility to 34 antimicrobial agentes by microdilution","volume":"22","author":"Swenson","year":"1982","journal-title":"Antimiob Agent Chemother."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"387","DOI":"10.4067\/S0716-97602012000400010","article-title":"Antioxidant, antibacterial activity and brine shrimp toxicity test of some mountainous lichens from Nepal","volume":"45","author":"Paudel","year":"2012","journal-title":"Biol. Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/1811199a0","article-title":"Antioxidant determinations by the use of a stable free radical","volume":"26","author":"Blois","year":"1958","journal-title":"Nature"},{"key":"ref_150","first-page":"210","article-title":"Antioxidation action of indole compounds during the autoxidation of linoleic acid","volume":"19","author":"Mitsuda","year":"1996","journal-title":"Nihon Eiyo Shokuryo Gakkai Shi"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s00300-009-0602-9","article-title":"Lecanoric acid, a secondary lichen substance with antioxidant properties from Umbilicaria Antarctica in maritime Antarctica (King George Island)","volume":"32","author":"Luo","year":"2009","journal-title":"Polar Biol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1745-4514.2010.00363.x","article-title":"The ethanol-water extract of Ramalina capitata has gastroprotective and antioxidative properties: An experimental study in rats with indomethacin-induced gastric injuries","volume":"35","author":"Halici","year":"2011","journal-title":"J. Food Biochem."},{"key":"ref_153","first-page":"2824","article-title":"Comparative evaluation of antioxidant activity and total phenolic content of selected species from Malaysia","volume":"4","author":"Stanly","year":"2011","journal-title":"J. Pharm. Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1055\/s-2002-23134","article-title":"Evaluation of the antiviral activity against Junin v\u00edrus of macrocyclic trichothecenes produced by the hypocrealean epibiont of Baccharis corififolia","volume":"68","author":"Rosso","year":"2002","journal-title":"Planta Med."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000194974","article-title":"Broad spectrum antiviral fractions from the lichen Ramalina farinacea (L.) Ach","volume":"55","author":"Esimone","year":"2009","journal-title":"Chemotherapy"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1248\/cpb.c12-00739","article-title":"Cytotoxic evaluation of phenolic compounds from lichens against melanona cells","volume":"61","author":"Alcantara","year":"2013","journal-title":"Chem. Pharm. Bull."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1080\/01635581.2013.785007","article-title":"Usnic acid inhibits and induces cell cycle arrest and apoptosis in human lung carcinoma A549 cells","volume":"65","author":"Singh","year":"2013","journal-title":"Nutr. Cancer"},{"key":"ref_158","first-page":"503","article-title":"Cytotoxic effect againts HeLa cells of polysaccharides from the lichen Ramalina celastri","volume":"29","author":"Buchi","year":"1997","journal-title":"J. Submicrosc. Cytol. Pathol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1055\/s-2004-832657","article-title":"Anti-proliferative effects of lichen-derived lipoxygenase inhibitors on twelve human cancer cell lines of different tissue origin in vitro","volume":"70","year":"2004","journal-title":"Planta Med."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1080\/14786410601101910","article-title":"In vitro cytotoxic activities of (+)-usnic acid and (\u2212)-usnic acid on V79, A549, and human lymphocyte cells and their non-genotoxicity on human lymphocytes","volume":"20","author":"Koparal","year":"2006","journal-title":"Nat. Prod. Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1055\/s-0029-1240851","article-title":"Cellular mechanisms of the anticancer effects of the lichen compound usnic acid","volume":"76","author":"Groeneweg","year":"2010","journal-title":"Planta Med."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tiv.2010.09.004","article-title":"Variable responses of different human cancer cells to the lichen compounds parietin, atranorin, usnic acid and gyrophoric acid","volume":"25","year":"2011","journal-title":"Toxicol. In Vitro"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.tiv.2012.01.017","article-title":"Lichen secondary metabolites are responsible for induction of apoptosis in HT-29 and A2780 human cancer cell lines","volume":"26","author":"Kello","year":"2012","journal-title":"Toxicol. In Vitro"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.ejca.2003.11.022","article-title":"Update on NCI in vitro drug screen utilities","volume":"40","author":"Holbeck","year":"2004","journal-title":"Eur. J. Cancer"},{"key":"ref_165","first-page":"61","article-title":"Fungitoxic activity of compounds isolated from lichens","volume":"7","author":"Honda","year":"1999","journal-title":"South. Braz. J. Chem."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"202","DOI":"10.5423\/PPJ.2008.24.2.202","article-title":"Antifungal activity of lichen forming fungi against Colletotrichum acutatum on hot pepper","volume":"24","author":"Wei","year":"2008","journal-title":"Plant Pathol. J."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.phymed.2009.07.018","article-title":"Antimycobacterial activity of lichen substances","volume":"17","author":"Honda","year":"2010","journal-title":"Phytomedicine"},{"key":"ref_168","unstructured":"Lim, J.H., Lee, H.G., Kim, I.C., Hong, S.G., Kim, D.G., Lee, Y.G., Lee, S.G., Han, S.J., Lee, H.S., and Lee, Y.M. (2011). Cosmetics Containing Usimine-C for Promoting Collagen Production. (KR 20,110,084,753 A)."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1590\/S0100-879X2011000400007","article-title":"Evaluation of the antischistosomal activity of sulfated \u03b1-d-glucan from the lichen Ramalina celastri free and encapsulated into liposomes","volume":"44","author":"Araojo","year":"2011","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1007\/s00436-008-0905-8","article-title":"Insecticidal activity of major lichen compounds, (\u2212)- and (+)-usnic acid, against the larvae of house mosquito, Culex pipiens L","volume":"102","author":"Cetin","year":"2008","journal-title":"Parasitol. Res."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/20\/5\/8952\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T20:46:30Z","timestamp":1760215590000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/20\/5\/8952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,19]]},"references-count":170,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5]]}},"alternative-id":["molecules20058952"],"URL":"https:\/\/doi.org\/10.3390\/molecules20058952","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,19]]}}}