{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:12:54Z","timestamp":1788480774863,"version":"build-2803163510"},"reference-count":38,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T00:00:00Z","timestamp":1437436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Castilleja tenuiflora has been used for the treatment of several Central Nervous System (CNS) diseases. Herein we report the antidepressant activity of the methanol extract from the leaves of this medicinal plant. The oral administration of MeOH extract (500 mg\/kg) induced a significant (p &lt; 0.05) decrement of the immobility parameter on Forced Swimming Test (FST) and an increment in the latency and duration of the hypnosis, induced by administration of sodium pentobarbital (Pbi, 40 mg\/kg, i.p.). Chemical analysis of this antidepressant extract allowed the isolation of (+)-piperitol-4-O-xylopyranosyl-(1\u21926)-O-glucopyranoside. This new furofuran lignan diglycoside was named tenuifloroside (1) and its complete chemical structure elucidation on the basis of 1D and 2D NMR spectra analysis of the natural compound 1 and its peracetylated derivative 1a is described. This compound was found together with two flavones\u2014apigenin and luteolin 5-methyl ether\u2014a phenylethanoid\u2014verbascoside\u2014and three iridoids\u2014geniposide, caryoptoside and aucubin. All these compounds were purified by successive normal and reverse phase column chromatography. Tenuifloroside, caryoptoside and luteolin 5-methyl ether were isolated from Castilleja genus for the first time. These findings demonstrate that C. tenuiflora methanol extract has beneficial effect on depressive behaviors, and the knowledge of its chemical constitution allows us to propose a new standardized treatment for future investigations of this species in depressive illness.<\/jats:p>","DOI":"10.3390\/molecules200713127","type":"journal-article","created":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T10:17:48Z","timestamp":1437473868000},"page":"13127-13143","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A New Furofuran Lignan Diglycoside and Other Secondary Metabolites from the Antidepressant Extract of  Castilleja tenuiflora Benth"],"prefix":"10.3390","volume":"20","author":[{"given":"Maribel","family":"Herrera-Ruiz","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec, Morelos 62790, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7479-9332","authenticated-orcid":false,"given":"Ricardo","family":"L\u00f3pez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec, Morelos 62790, Mexico"},{"name":"Departamento de Biotecnolog\u00eda, Centro de Desarrollo de Productos Bi\u00f3ticos,  Instituto Polit\u00e9cnico Nacional, P.O. Box 24, Yautepec, Morelos 62730, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7479-9332","authenticated-orcid":false,"given":"Gabriela","family":"Trejo-Tapia","sequence":"additional","affiliation":[{"name":"Departamento de Biotecnolog\u00eda, Centro de Desarrollo de Productos Bi\u00f3ticos,  Instituto Polit\u00e9cnico Nacional, P.O. Box 24, Yautepec, Morelos 62730, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Dom\u00ednguez-Mendoza","sequence":"additional","affiliation":[{"name":"Laboratorio de RMN, Centro de Investigaciones Qu\u00edmicas, Universidad Aut\u00f3noma del Estado de Morelos, Av. Universidad 1001, Colonia Chamilpa C.P. Cuernavaca, Morelos 62210, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manases","family":"Gonz\u00e1lez-Cortazar","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec, Morelos 62790, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Tortoriello","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec, Morelos 62790, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2233-5958","authenticated-orcid":false,"given":"Alejandro","family":"Zamilpa","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec, Morelos 62790, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2307\/2805830","article-title":"Four new species of mexican castilleja (subgenus Castilleja, Scrophulariaceae) and their relatives","volume":"28","author":"Holmgren","year":"1976","journal-title":"Brittonia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0378-8741(00)00341-X","article-title":"Plants used against cancer-an extension of the work of Jonathan Hartwell","volume":"73","author":"Graham","year":"2000","journal-title":"J. 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