{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:57:13Z","timestamp":1787029033314,"version":"build-2736575974"},"reference-count":93,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T00:00:00Z","timestamp":1445558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31370947"],"award-info":[{"award-number":["31370947"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373150"],"award-info":[{"award-number":["81373150"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Bone metabolism is a lifelong process for maintaining skeletal system homeostasis, which is regulated by bone-resorbing osteoclasts and bone-forming osteoblasts. Aberrant differentiation of osteoclasts and osteoblasts leads to imbalanced bone metabolism, resulting in ossification and osteolysis diseases. MicroRNAs (miRNAs) are pivotal factors in regulating bone metabolism via post-transcriptional inhibition of target genes. Recent studies have revealed that miR-223 exerts multiple effects on bone metabolism, especially in the processes of osteoclast and osteoblasts differentiation. In this review, we highlight the roles of miR-223 during the processes of osteoclast and osteoblast differentiation, as well as the potential clinical applications of miR-223 in bone metabolism disorders.<\/jats:p>","DOI":"10.3390\/molecules201019433","type":"journal-article","created":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T08:27:06Z","timestamp":1445675226000},"page":"19433-19448","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The Multiple Roles of Microrna-223 in Regulating  Bone Metabolism"],"prefix":"10.3390","volume":"20","author":[{"given":"Yong","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Orthopedics, General Hospital of Chinese PLA, Beijing 100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, General Hospital of Chinese PLA, Beijing 100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanpan","family":"Gao","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Medical Molecular Biology, Department of Immunology,  Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ge","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Medical Molecular Biology, Department of Immunology,  Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peifu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, General Hospital of Chinese PLA, Beijing 100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2147\/PPA.S46192","article-title":"A review of denosumab for the treatment of osteoporosis","volume":"8","author":"Miyazaki","year":"2014","journal-title":"Patient Prefer. 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