{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:13:47Z","timestamp":1784182427253,"version":"3.55.0"},"reference-count":70,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T00:00:00Z","timestamp":1451347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The Schmidt reaction of aromatic aldehydes using a substoichiometric amount (40 mol %) of triflic acid is described. Low catalyst loading was enabled by a strong hydrogen-bond-donating solvent hexafluoro-2-propanol (HFIP). This improved protocol tolerates a broad scope of aldehydes with diverse functional groups and the corresponding nitriles were obtained in good to high yields without the need for aqueous work up.<\/jats:p>","DOI":"10.3390\/molecules21010045","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T10:00:08Z","timestamp":1451383208000},"page":"45","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Improved Schmidt Conversion of Aldehydes to Nitriles Using Azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-propanol"],"prefix":"10.3390","volume":"21","author":[{"given":"Hashim","family":"Motiwala","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, Delbert M. 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Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/9780470771709.ch9","article-title":"Preparation and synthetic applications of cyano compounds","volume":"Volume 2","author":"Fatiadi","year":"1983","journal-title":"Triple-Bonded Functional Groups"},{"key":"ref_4","unstructured":"Larock, R.C. (1989). Comprehensive Organic Transformations, Wiley-VCH."},{"key":"ref_5","unstructured":"Kleemann, A., Engel, J., Kutscher, B., and Reichert, D. (2001). Pharmaceutical Substances: Syntheses, Patents, Applications, Georg Thieme. [4th ed.]."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Smith, M.B., and March, J. (2007). March\u2019s Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, Wiley. [6th ed.].","DOI":"10.1002\/0470084960"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1002\/cber.188401702202","article-title":"Substitution of the amido-group in aromatic derivatives by chlorine, bromine, and cyanogen","volume":"17","author":"Sandmeyer","year":"1884","journal-title":"Chem. Ber."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1002\/cber.188501801322","article-title":"Ueberf\u00fchrung der drei nitraniline in die nitrobenzo\u00ebs\u00e4uren","volume":"18","author":"Sandmeyer","year":"1885","journal-title":"Chem. Ber."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1021\/cr60132a001","article-title":"The preparation of nitriles","volume":"42","author":"Mowry","year":"1948","journal-title":"Chem. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1002\/cber.19190520840","article-title":"Halogen attached to a ring carbon atom and its replacement by other substituents. I. Replacement of the halogen by the carboxyl group","volume":"52","author":"Rosenmund","year":"1919","journal-title":"Chem. Ber."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/jlac.19314880107","article-title":"Fluoranthen und seine derivate. III. Mitteilung","volume":"488","author":"Manz","year":"1931","journal-title":"Justus Liebigs Ann. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1246\/cl.1973.471","article-title":"Palladium(II) catalyzed synthesis of aryl cyanides from aryl halides","volume":"2","author":"Takagi","year":"1973","journal-title":"Chem. Lett."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1021\/cr00080a006","article-title":"Cyanation of aromatic halides","volume":"87","author":"Ellis","year":"1987","journal-title":"Chem. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1039\/c1cs15004a","article-title":"Recent developments and perspectives in palladium-catalyzed cyanation of aryl halides: Synthesis of benzonitriles","volume":"40","author":"Anbarasan","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.1002\/ejoc.201300052","article-title":"Copper-mediated cyanation of aryl halides by activation of benzyl Cyanide as the cyanide source","volume":"2013","author":"Wen","year":"2013","journal-title":"Eur. J. Org. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"10272","DOI":"10.1021\/ja104917t","article-title":"A new combined source of \u201cCN\u201d from N,N-dimethylformamide and ammonia in the palladium-catalyzed cyanation of aryl C\u2013H bonds","volume":"132","author":"Kim","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1021\/ol1000439","article-title":"Palladium-catalyzed direct cyanation of indoles with K4[Fe(CN)6]","volume":"12","author":"Yan","year":"2010","journal-title":"Org. Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1021\/ol100772u","article-title":"Copper-catalyzed cyanation of heterocycle carbon-hydrogen bonds","volume":"12","author":"Do","year":"2010","journal-title":"Org. Lett."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5608","DOI":"10.1021\/ol202335p","article-title":"Lewis acid catalyzed direct cyanation of indoles and pyrroles with N-cyano-N-phenyl-p-toluenesulfonamide (NCTS)","volume":"13","author":"Yang","year":"2011","journal-title":"Org. Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"12374","DOI":"10.1021\/ja204063z","article-title":"Direct transformation of N,N-dimethylformamide to \u2013CN: Pd-catalyzed cyanation of heteroarenes via C\u2013H functionalization","volume":"133","author":"Ding","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref_21","unstructured":"Pollak, P., Romeder, G., Hagedorn, F., and Gelbke, H.-P. (2000). Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH."},{"key":"ref_22","unstructured":"L\u00fccke, B., and Martin, A. (2001). Fine Chemicals through Heterogeneous Catalysis, VCH-Wiley."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1002\/adsc.200404027","article-title":"Oxidation and ammoxidation of aromatics","volume":"346","author":"Narayana","year":"2004","journal-title":"Adv. Synth. Catal."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"9908","DOI":"10.1016\/j.tet.2005.06.061","article-title":"A practical synthesis of highly functionalized aryl nitriles through cyanation of aryl bromides employing heterogeneous Pd\/C: In quest of an industrially viable process","volume":"61","author":"Hatsuda","year":"2005","journal-title":"Tetrahedron"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1016\/S0040-4020(02)00304-6","article-title":"Activated dimethyl sulfoxide dehydration of amide and its application to one-pot preparation of benzyl-type perfluoroimidates","volume":"58","author":"Nakajima","year":"2002","journal-title":"Tetrahedron"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Kuo, C.-W., Zhu, J.-L., Wu, J.-D., Chu, C.-M., Yao, C.-F., and Shia, K.-S. (2007). A convenient new procedure for converting primary amides into nitriles. Chem. Commun., 301\u2013303.","DOI":"10.1039\/B614061K"},{"key":"ref_27","first-page":"657","article-title":"Synthetic Methods and Reactions; 82. Cyanuric Chloride, a Mild Dehydrating Agent in the Preparation of Nitriles from Amides","volume":"1980","author":"Olah","year":"1980","journal-title":"Synthesis"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1021\/ol900716q","article-title":"A general and convenient catalytic synthesis of nitriles from amides and silanes","volume":"11","author":"Zhou","year":"2009","journal-title":"Org. Lett."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.1021\/ol0168768","article-title":"Highly efficient and catalytic conversion of aldoximes to nitriles","volume":"3","author":"Yang","year":"2001","journal-title":"Org. Lett."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1016\/j.tet.2012.01.067","article-title":"Phosphonium salt-catalysed synthesis of nitriles from in situ activated oximes","volume":"68","author":"Denton","year":"2012","journal-title":"Tetrahedron"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1021\/ol0260977","article-title":"[RuCl2(p-cymene)]2 on carbon: An efficient, selective, reusable, and environmentally versatile heterogeneous catalyst","volume":"4","author":"Choi","year":"2002","journal-title":"Org. Lett."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"6272","DOI":"10.1021\/jo025960d","article-title":"Beckmann rearrangement of oximes under very mild conditions","volume":"67","author":"Giacomelli","year":"2002","journal-title":"J. Org. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1055\/s-2002-25333","article-title":"A clean conversion of aldehydes to nitriles using a solid-supported hydrazine","volume":"2002","author":"Baxendale","year":"2002","journal-title":"Synlett"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1080\/00397910902788174","article-title":"A facile one-pot conversion of aldehydes into nitriles","volume":"39","author":"Chill","year":"2009","journal-title":"Synth. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"0625","DOI":"10.1055\/s-2002-22701","article-title":"Highly convenient and efficient one-pot conversions of aldehydes into nitriles and ketones into amides using HY-zeolite","volume":"2002","author":"Srinivas","year":"2002","journal-title":"Synlett."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"9334","DOI":"10.1021\/jo301133y","article-title":"A chemoselective, one-pot transformation of aldehydes to nitriles","volume":"77","author":"Gori","year":"2012","journal-title":"J. Org. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1055\/s-0030-1261181","article-title":"A practical and cost-efficient, one-pot conversion of aldehydes into nitriles mediated by \u201cactivated DMSO\u201d","volume":"2011","author":"Augustine","year":"2011","journal-title":"Synlett"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/j.tetlet.2008.02.046","article-title":"A novel system for the synthesis of nitriles from aldehydes using aqueous ammonia and sodium dichloroiodate","volume":"49","author":"Telvekar","year":"2008","journal-title":"Tetrahedron Lett."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1002\/anie.201412256","article-title":"Access to nitriles from aldehydes mediated by an oxoammonium salt","volume":"54","author":"Kelly","year":"2015","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_40","first-page":"52","article-title":"Direct synthesis of nitriles from alcohols or aldehydes using H5IO6\/KI in aqueous ammonia","volume":"43","author":"Zolfigol","year":"2012","journal-title":"Synth. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1055\/s-0033-1339904","article-title":"One-pot synthesis of nitriles from aldehydes catalyzed by deep eutectic solvent","volume":"45","author":"Patil","year":"2013","journal-title":"Synthesis"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1055\/s-0029-1218388","article-title":"Propylphosphonic anhydride (T3P\u00ae): A remarkably efficient reagent for the one-pot transformation of aromatic, heteroaromatic, and aliphatic aldehydes to nitriles","volume":"2009","author":"Augustine","year":"2009","journal-title":"Synlett"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1055\/s-2007-980338","article-title":"An efficient new procedure for the one-pot conversion of aldehydes into the corresponding nitriles","volume":"2007","author":"Zhu","year":"2007","journal-title":"Synlett."},{"key":"ref_44","first-page":"1","article-title":"The Schmidt reaction","volume":"78","author":"Wrobleski","year":"2012","journal-title":"Org. React."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1021\/ja01125a010","article-title":"The Schmidt reaction applied to aldehydes and epoxides","volume":"74","author":"McEwen","year":"1952","journal-title":"J. Am. Chem. Soc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5364","DOI":"10.1021\/jo3008258","article-title":"Chemoselective Schmidt reaction mediated by triflic acid: Selective synthesis of nitriles from aldehydes","volume":"77","author":"Rokade","year":"2012","journal-title":"J. Org. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1016\/j.tetlet.2013.02.051","article-title":"Schmidt reaction in ionic liquids: Highly efficient and selective conversion of aromatic and heteroaromatic aldehydes to nitriles with [BMIM(SO3H)][OTf] as catalyst and [BMIM][PF6] as solvent","volume":"54","author":"Nandi","year":"2013","journal-title":"Tetrahedron Lett."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"5686","DOI":"10.1002\/ejoc.201402662","article-title":"One-pot sequential Schmidt and Ritter reactions for the synthesis of N-tert-butyl amides","volume":"2014","author":"Hazarika","year":"2014","journal-title":"Eur. J. Org. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"9000","DOI":"10.1021\/ja402848c","article-title":"Overcoming Product Inhibition in Catalysis of the Intramolecular Schmidt Reaction","volume":"135","author":"Motiwala","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1021\/ja01181a098","article-title":"The Schmidt reaction: Experimental conditions and mechanism","volume":"70","author":"Smith","year":"1948","journal-title":"J. Am. Chem. Soc."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1021\/jo00341a012","article-title":"Theoretical study of the barrier to nitrogen inversion in N-cyano- and N-diazoformimine. Mechanism of the Schmidt reaction","volume":"47","author":"Bach","year":"1982","journal-title":"J. Org. Chem."},{"key":"ref_52","first-page":"339","article-title":"Mechanism of the Schmidt reaction. XVIII. Kinetics of reaction of substituted benzaldehydes with hydrazoic acid in aqueous solutions of sulfuric acid","volume":"13","author":"Ostrovskii","year":"1977","journal-title":"Zh. Org. Khim."},{"key":"ref_53","first-page":"1027","article-title":"Mechanism of the Schmidt reaction. XIV. Determination of the ratio of reaction products of substituted benzaldehydes with hydrazoic acid","volume":"11","author":"Ostrovskii","year":"1975","journal-title":"Zh. Org. Khim."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4494","DOI":"10.1016\/j.tet.2011.04.038","article-title":"Superelectrophilic chemistry of amino-nitriles and related substrates","volume":"67","author":"Raja","year":"2011","journal-title":"Tetrahedron"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1021\/ol401906q","article-title":"Direct oxidative conversion of methylarenes into aromatic nitriles","volume":"15","author":"Tsuchiya","year":"2013","journal-title":"Org. Lett."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1021\/ol500075h","article-title":"Organoselenium-catalyzed mild dehydration of aldoximes: An unexpected practical method for organonitrile synthesis","volume":"16","author":"Yu","year":"2014","journal-title":"Org. Lett."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/j.tetlet.2014.01.116","article-title":"Metal-free chemoselective oxidation of sulfides by in situ generated Koser\u2019s reagent in aqueous media","volume":"55","author":"Yu","year":"2014","journal-title":"Tetrahedron Lett."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"6328","DOI":"10.1021\/jo4008157","article-title":"Deoxygenation of sulfoxides to sulfides with thionyl chloride and triphenylphosphine: Competition with the Pummerer reaction","volume":"78","author":"Jang","year":"2013","journal-title":"J. Org. Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"7575","DOI":"10.1021\/jo4011415","article-title":"Development of second generation gold-supported palladium material with low-leaching and recyclable characteristics in aromatic amination","volume":"78","author":"Arai","year":"2013","journal-title":"J. Org. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1039\/C3RA46553E","article-title":"Visible-light-mediated efficient conversion of aldoximes and primary amides into nitriles","volume":"4","author":"Yadav","year":"2014","journal-title":"RSC Adv."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"6088","DOI":"10.1016\/j.tetlet.2009.08.069","article-title":"Ionic liquid-promoted dehydration of aldoximes: A convenient access to aromatic, heteroaromatic and aliphatic nitriles","volume":"50","author":"Saha","year":"2009","journal-title":"Tetrahedron Lett."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1016\/j.tetlet.2013.05.149","article-title":"An unexpected involvement of ethyl-2-cyano-2-(hydroxyimino) acetate cleaved product in the promotion of the synthesis of nitriles from aldoximes: A mechanistic perception","volume":"54","author":"Dev","year":"2013","journal-title":"Tetrahedron Lett."},{"key":"ref_63","first-page":"1499","article-title":"Oxidation of aromatic compounds. V. Oxidation of substituted benzonitriles and 2,4,6-triaryl-1,3,5-triazines in the HSO3F-PbO2 system","volume":"32","author":"Rudenko","year":"1996","journal-title":"Zh. Org. Khim."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"8400","DOI":"10.1016\/j.tet.2013.07.063","article-title":"Copper-mediated cyanation of aryl boronic acids using benzyl cyanide","volume":"69","author":"Luo","year":"2013","journal-title":"Tetrahedron"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1021\/ol5032359","article-title":"Mild palladium-catalyzed cyanation of (hetero)aryl halides and triflates in aqueous media","volume":"17","author":"Cohen","year":"2015","journal-title":"Org. Lett."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1021\/ol500618w","article-title":"Chemoselective palladium-catalyzed cyanation of alkenyl halides","volume":"16","author":"Powell","year":"2014","journal-title":"Org. Lett."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"8053","DOI":"10.1021\/jo201280x","article-title":"An \u03b1-diaminoboryl carbanion assisted stereoselective single-pot preparation of \u03b1,\u03b2-disubstituted acrylonitriles","volume":"76","author":"Tomioka","year":"2011","journal-title":"J. Org. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1021\/ol101094u","article-title":"An efficient transformation from benzyl or allyl halides to aryl and alkenyl nitriles","volume":"12","author":"Zhou","year":"2010","journal-title":"Org. Lett."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1021\/jo200023r","article-title":"An investigation into the one-pot Heck olefination-hydrogenation reaction","volume":"76","author":"Geoghegan","year":"2011","journal-title":"J. Org. Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.1016\/j.tetlet.2010.04.056","article-title":"Microwave-promoted, one-pot conversion of alkoxymethylated protected alcohols into their corresponding nitriles, bromides, and iodides using [bmim][InCl4] as a green catalyst","volume":"51","author":"Mirjafari","year":"2010","journal-title":"Tetrahedron Lett."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/21\/1\/45\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T20:55:00Z","timestamp":1760216100000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/21\/1\/45"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,29]]},"references-count":70,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1]]}},"alternative-id":["molecules21010045"],"URL":"https:\/\/doi.org\/10.3390\/molecules21010045","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,29]]}}}