{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:17:58Z","timestamp":1760242678128,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Leading Academic Discipline Project of Beijing Education Bureau","award":["BMU20110254"],"award-info":[{"award-number":["BMU20110254"]}]},{"name":"the fund for Fostering Talents in Basic Science of the National Natural Science Foundation of China","award":["J1030831\/J0108"],"award-info":[{"award-number":["J1030831\/J0108"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Nano-TiO2 is widely applied in the automobile exhaust hose reels as a catalyst to reduce oxynitride emissions, including nitric oxide (NO). In the biomedicine field, NO plays an important role in vasodilation and edema formation in human bodies. However, the deswelling activity of nano-TiO2 has not been reported. Here, we demonstrated that nano-TiO2 can significantly degrade the production of NO in LPS-induced RAW264.7 mouse macrophages. Further study indicated that nano-TiO2 exhibited an effect on vascular permeability inhibition, and prevented carrageenan-induced footpad edema. Therefore, we prepared a nano-TiO2 ointment and observed similar deswelling effects. In conclusion, nano-TiO2 might act as a novel deswelling agent related with its degradation of NO, which will aid in our ability to design effective interventions for edema involved diseases.<\/jats:p>","DOI":"10.3390\/molecules21010057","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T02:29:07Z","timestamp":1451960947000},"page":"57","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of the Nano-TiO2 as a Novel Deswelling Material"],"prefix":"10.3390","volume":"21","author":[{"given":"Ming","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China"},{"name":"Key Laboratory of Medical Immunology, Ministry of Health, Beijing 100191, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1870-2153","authenticated-orcid":false,"given":"Yue-Long","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China"},{"name":"Key Laboratory of Medical Immunology, Ministry of Health, Beijing 100191, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China"},{"name":"Key Laboratory of Medical Immunology, Ministry of Health, Beijing 100191, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng-Yun","family":"Chu","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Liao Ning University of Traditional Chinese Medicine, Shenyang 116600, Liao Ning, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Liao Ning University of Traditional Chinese Medicine, Shenyang 116600, Liao Ning, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4167-5250","authenticated-orcid":false,"given":"Yue-Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China"},{"name":"Key Laboratory of Medical Immunology, Ministry of Health, Beijing 100191, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,1,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jenvman.2013.08.006","article-title":"An overview of photocatalysis phenomena applied to NOx abatement","volume":"129","author":"Andrade","year":"2013","journal-title":"J. Environ. Manag."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/cssc.201000158","article-title":"Metal-free porphyrin-sensitized mesoporous titania films for visible-light indoor air oxidation","volume":"3","author":"Ismail","year":"2010","journal-title":"ChemSusChem"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/288373a0","article-title":"The obligatory role of the endothelial cell in the relaxation of arterial smooth muscle by acetylcholine","volume":"288","author":"Furchgott","year":"1980","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1161\/01.RES.53.5.557","article-title":"Role of endothelium in responses of vascular smooth muscle","volume":"53","author":"Furchgott","year":"1983","journal-title":"Circ. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"9265","DOI":"10.1073\/pnas.84.24.9265","article-title":"Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide","volume":"84","author":"Ignarro","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"14879","DOI":"10.3390\/molecules200814879","article-title":"Diterpenoids from Saliva plebeian R. Br. and Their Antioxidant and Anti-Inflammatory Activities","volume":"20","author":"Zhang","year":"2015","journal-title":"Molecules"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"14474","DOI":"10.3390\/molecules200814474","article-title":"Anti-inflammatory Activity of Heterocarpin from the Salt Marsh Plant Corydalis heterocarpa in LPS-Induced RAW 264.7 Macrophage Cells","volume":"20","author":"Kim","year":"2015","journal-title":"Molecules"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6888","DOI":"10.3390\/molecules20046888","article-title":"Anti-inflammatory Effect of Wogonin on RAW 264.7 Mouse Macrophages Induced with Polyinosinic-Polycytidylic Acid","volume":"20","author":"Lee","year":"2015","journal-title":"Molecules"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3390\/molecules20010625","article-title":"Optimization of astillbin extraction from the rhizome of Smilax glabra, and evalution of its anti-inflammatory effect and probable underlying mechanism in lipopolysaccharide-induced RAW264.7 macrophages","volume":"20","author":"Lu","year":"2015","journal-title":"Molecules"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.niox.2010.12.010","article-title":"Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease","volume":"25","author":"Olson","year":"2011","journal-title":"Nitric Oxide"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1472-6882-14-89","article-title":"Role of berberine in anti-bacterial as a high-affinity LPS antagonist binding to TLR4\/MD-2 receptor","volume":"14","author":"Chu","year":"2014","journal-title":"BMC Complement. Altern. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.niox.2009.07.002","article-title":"What is the real physiological NO concentration in vivo?","volume":"21","author":"Hall","year":"2009","journal-title":"Nitric Oxide"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"36167","DOI":"10.1074\/jbc.R400017200","article-title":"Update on mechanism and catalytic regulation in the NO synthases","volume":"279","author":"Stuehr","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1124\/pr.110.002907","article-title":"cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action","volume":"62","author":"Francis","year":"2010","journal-title":"Pharmacol. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s00424-009-0773-9","article-title":"The multiple actions of NO","volume":"459","author":"Gao","year":"2010","journal-title":"Pflug. Arch. Eur. J. Phys."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"9628","DOI":"10.3390\/molecules19079628","article-title":"Ruthenium complexes as NO donors for vascular relaxation induction","volume":"19","author":"Silva","year":"2014","journal-title":"Molecules"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Yang, B., Cai, B., Deng, P., Wu, X., Guan, Y., Zhang, B., Cai, W., Schaper, J., and Schaper, W. (2015). Nitric oxide increases arterial endotheial permeability through mediating VE-cadherin expression during arteriogenesis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0127931"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.biomaterials.2009.10.003","article-title":"Toxicological characteristics of nanaparticulate anatase titanium dioxide in mice","volume":"31","author":"Duan","year":"2010","journal-title":"Biomaterials"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.fct.2010.11.036","article-title":"Lack of skin carcinogenicity of topically applied titanium dioxide nanoparticles in the mouse","volume":"49","author":"Furukawa","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jaad.2009.02.051","article-title":"The safety of nanosized particles in titanium dioxide- and zinc oxide-based sunscreens","volume":"61","author":"Newman","year":"2009","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3109\/1547691X.2013.844750","article-title":"Route-dependent systemic and local immune effects following exposure to solutions prepared from titanium dioxide nanoparticles","volume":"11","author":"Auttachoat","year":"2014","journal-title":"J. Immunotoxicol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3181\/00379727-111-27849","article-title":"Carregeenin-induced edema in hind paw of the rat as assay for anti-inflammatory drugs","volume":"11","author":"Winter","year":"1962","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5374","DOI":"10.3390\/molecules20045374","article-title":"Anti-inflammatory screening and molecular modeling of some novel coumarin derivatives","volume":"20","year":"2015","journal-title":"Molecules"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.3390\/molecules19033310","article-title":"Appraisal of antioxidant and anti-inflammatory activities of various extracts from the fruiting bodies of Pleurotus florida","volume":"19","author":"Im","year":"2014","journal-title":"Molecules"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1093\/toxsci\/kfq041","article-title":"Lack of significant dermal penetration of titanium dioxide from sunscreen formulations containing nano- and submicron-size TiO2 particles","volume":"115","author":"Sadrieh","year":"2010","journal-title":"Toxicol. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/toxsci\/kfp139","article-title":"Quantitative determination of skin penetration of PEG-coated CdSe quantum dots in dermabraded but not intact SKH-1 hairless mouse skin","volume":"111","author":"Gopee","year":"2009","journal-title":"Toxicol. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Chu, M., Xu, L., Zhang, M.B., Chu, Z.Y., and Wang, Y.D. (2015). Role of Baicalin in anti-influenza virus A as a potent inducer of IFN-gamma. BioMed Res. Int., 2015.","DOI":"10.1155\/2015\/263630"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"13532","DOI":"10.1073\/pnas.0803852105","article-title":"Pathogen induction of CXCR4\/TLR2 cross-talk impairs host defense function","volume":"105","author":"Hajishengallis","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Chu, M., Kang, J.-R., Wang, W., Li, H., Feng, J.-H., Chu, Z.-Y., Zhang, M.-B., Xu, L., and Wang, Y.-D. (2015). Evaluation of human epidermal growth factor receptor 2 in breast cancer with a novel specific aptamer. Cell. Mol. Immunol.","DOI":"10.1038\/cmi.2015.31"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/21\/1\/57\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:17:12Z","timestamp":1760210232000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/21\/1\/57"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,4]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1]]}},"alternative-id":["molecules21010057"],"URL":"https:\/\/doi.org\/10.3390\/molecules21010057","relation":{},"ISSN":["1420-3049"],"issn-type":[{"type":"electronic","value":"1420-3049"}],"subject":[],"published":{"date-parts":[[2016,1,4]]}}}