{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:59:56Z","timestamp":1790114396380,"version":"4.0.1"},"reference-count":67,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T00:00:00Z","timestamp":1453766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The study was aimed at exploring the curative effects of Rubus coreanus (RC) vinegar against postmenopausal osteoporosis by using ovariectomized rats as a model. The investigations were performed in five groups: sham, ovariectomized (OVX) rats without treatment, low-dose RC vinegar (LRV)-treated OVX rats, high-dose RC vinegar (HRV)-treated OVX rats and alendronate (ALEN)-treated OVX rats. The efficacy of RC vinegar was evaluated using physical, biochemical, histological and metabolomic parameters. Compared to the OVX rats, the LRV and HRV groups showed positive effects on the aforementioned parameters, indicating estrogen regulation. Plasma metabolome analysis of the groups using gas chromatography-time of flight mass spectrometry (GC-TOF-MS) and ultra-performance liquid chromatography quadrupole-TOF-MS (UPLC-Q-TOF-MS) with multivariate analysis revealed 19 and 16 metabolites, respectively. Notably, the levels of butyric acid, phenylalanine, glucose, tryptophan and some lysophosphatidylcholines were marginally increased in RC vinegar-treated groups compared to OVX. However, the pattern of metabolite levels in RC vinegar-treated groups was found similar to ALEN, but differed significantly from that in sham group. The results highlight the prophylactic and curative potential of dietary vinegar against postmenopausal osteoporosis. RC vinegar could be an effective natural alternative for the prevention of postmenopausal osteoporosis.<\/jats:p>","DOI":"10.3390\/molecules21020149","type":"journal-article","created":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T10:00:42Z","timestamp":1453802442000},"page":"149","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Metabolite Profiling Reveals the Effect of Dietary Rubus coreanus Vinegar on Ovariectomy-Induced Osteoporosis in a Rat Model"],"prefix":"10.3390","volume":"21","author":[{"given":"Mee","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Bioscience and Biotechnology, Kon-Kuk University, Seoul 143-701, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyang","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology, Kon-Kuk University, Seoul 143-701, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6008-060X","authenticated-orcid":false,"given":"Digar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology, Kon-Kuk University, Seoul 143-701, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo","family":"Yeo","sequence":"additional","affiliation":[{"name":"Fermented Food Science Division, Department of Agro-food Resource, National Academy of Agricultural Sciences, Rural Development Administration, Jeollabuk-do 565-851, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong","family":"Baek","sequence":"additional","affiliation":[{"name":"Fermented Food Science Division, Department of Agro-food Resource, National Academy of Agricultural Sciences, Rural Development Administration, Jeollabuk-do 565-851, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8536-0835","authenticated-orcid":false,"given":"Yoo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Gyeonggi-do 446-791, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology, Kon-Kuk University, Seoul 143-701, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/ncprheum0070","article-title":"Mechanisms of disease: Is osteoporosis the obesity of bone?","volume":"2","author":"Rosen","year":"2006","journal-title":"Nat. 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