{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:08:33Z","timestamp":1790381313972,"version":"4.1.0"},"reference-count":18,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T00:00:00Z","timestamp":1459123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Plasmodium falciparum thioredoxin reductase (PfTrxR) has been identified as a potential drug target to combat growing antimalarial drug resistance. Medicines for Malaria Venture (MMV) has pre-screened and identified a set of 400 antimalarial compounds called the Malaria Box. From those, we have evaluated their mechanisms of action through inhibition of PfTrxR and found new active chemical scaffolds. Five compounds with significant PfTrxR inhibitory activity, with IC50 values ranging from 0.9\u20137.5 \u00b5M against the target enzyme, were found out of the Malaria Box.<\/jats:p>","DOI":"10.3390\/molecules21040424","type":"journal-article","created":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T16:00:28Z","timestamp":1459267228000},"page":"424","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Preliminary LC-MS Based Screening for Inhibitors of Plasmodium falciparum Thioredoxin Reductase (PfTrxR) among a Set of Antimalarials from the Malaria Box"],"prefix":"10.3390","volume":"21","author":[{"given":"Neil","family":"Tiwari","sequence":"first","affiliation":[{"name":"Department of Drug Discovery and Development, Auburn University, 4306 Walker Building, Auburn, AL 36849, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Drug Discovery and Development, Auburn University, 4306 Walker Building, Auburn, AL 36849, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Calder\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Drug Discovery and Development, Auburn University, 4306 Walker Building, Auburn, AL 36849, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,3,28]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization World Malaria Report 2014. 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