{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T19:03:01Z","timestamp":1785783781814,"version":"3.56.0"},"reference-count":67,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A novel one pot synthesis of pyrazolo[4\u2032,3\u2032:5,6]pyrido[2,3-d]pyrimidine-diones, via a five-component reaction, involving, hydrazine hydrate, ethyl acetoacetate, and 1,3-dimethyl barbituric acid, an appropriate aryl aldehydes and ammonium acetate catalyzed via both of heterogeneous and homogeneous catalysis in water, is reported.<\/jats:p>","DOI":"10.3390\/molecules21040441","type":"journal-article","created":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T10:31:20Z","timestamp":1459506680000},"page":"441","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["A Novel and Efficient Five-Component Synthesis of Pyrazole Based Pyrido[2,3-d]pyrimidine-diones in Water: A Triply Green Synthesis"],"prefix":"10.3390","volume":"21","author":[{"given":"Majid","family":"Heravi","sequence":"first","affiliation":[{"name":"Department of Chemistry, School of Science, Alzahra University, Vanak, Tehran 1993893973, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansoureh","family":"Daraie","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Science, Alzahra University, Vanak, Tehran 1993893973, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,4,1]]},"reference":[{"key":"ref_1","unstructured":"Chan, M. 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