{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:43:25Z","timestamp":1791585805313,"version":"4.3.4"},"reference-count":38,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T00:00:00Z","timestamp":1465862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Methanolic extracts from the aerial parts and roots of two Scutellaria species, S. alpina and S. altissima, and five polyphenols from these plants demonstrated a significant ability to inhibit the formation of advanced glycation end-products (AGE) in vitro. S. alpina, which is richer in polyphenolic compounds, had strong antiglycation properties. These extracts demonstrated also high activity in the FRAP (ferric-reducing antioxidant power), antiradical (DPPH) and lipid peroxidation inhibition assays. Among the pure compounds, baicalin was the strongest glycation inhibitor (90.4% inhibition at 100 \u03bcg\/mL), followed by luteolin (85.4%). Two other flavone glycosides had about half of this activity. Verbascoside was similar to the reference drug aminoguanidine (71.2% and 75.9%, respectively). The strong correlation observed between AGE inhibition and total flavonoid content indicated that flavonoids contribute significantly to antiglycation properties. A positive correlation was also observed between antiglycative and antioxidant activities. The studied skullcap species can be considered as a potential source of therapeutic agents for hyperglycemia-related disorders.<\/jats:p>","DOI":"10.3390\/molecules21060739","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T11:12:12Z","timestamp":1465902732000},"page":"739","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Inhibition of Advanced Glycation End-Product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L."],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4793-4604","authenticated-orcid":false,"given":"Izabela","family":"Grzegorczyk-Karolak","sequence":"first","affiliation":[{"name":"Department of Biology and Pharmaceutical Botany, Medical University of Lodz, ul. Muszynskiego 1, Lodz 90\u2013151, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9257-1497","authenticated-orcid":false,"given":"Krzysztof","family":"Go\u0142\u0105b","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biochemistry, Wroclaw Medical University, ul. Borowska 211A, Wroclaw 50-556, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Gburek","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biochemistry, Wroclaw Medical University, ul. Borowska 211A, Wroclaw 50-556, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halina","family":"Wysoki\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Biology and Pharmaceutical Botany, Medical University of Lodz, ul. Muszynskiego 1, Lodz 90\u2013151, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7283-2653","authenticated-orcid":false,"given":"Adam","family":"Matkowski","sequence":"additional","affiliation":[{"name":"Department of Biology and Pharmaceutical Botany, Wroclaw Medical University, ul. Borowska 211, Wroclaw 50-556, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,6,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"14320","DOI":"10.3390\/molecules181114320","article-title":"Tuning a 96-well microtiter plate fluorescence-based assay to identify AGE inhibitors in crude plant extracts","volume":"18","author":"Sanguinet","year":"2013","journal-title":"Molecules"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"946","DOI":"10.2174\/138161208784139710","article-title":"Role of AGEs in diabetic nephropathy","volume":"14","author":"Fukami","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"953","DOI":"10.2174\/138161208784139774","article-title":"Role of advanced glycation end products in diabetic neuropathy","volume":"14","author":"Sugimoto","year":"2008","journal-title":"Curr. Pharm. 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