{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:18:14Z","timestamp":1792199894448,"version":"4.4.0"},"reference-count":51,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2016,6,25]],"date-time":"2016-06-25T00:00:00Z","timestamp":1466812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Aerial parts of Achillea moschata Wulfen (Asteraceae) growing wild in the Italian Rhaetian Alps were investigated to describe, for the first time, their phenolic content, as well as to characterize the essential oil. Inspection of the metabolic profile combining HPLC-DAD and ESI-MS\/MS data showed that the methanol extract contained glycosylated flavonoids with luteolin and apigenin as the main aglycones. Among them, the major compound was 7-O-glucosyl apigenin. Caffeoyl derivates were other phenolics identified. The essential oil obtained by steam distillation and investigated by GC\/FID and GC\/MS showed camphor, 1,8-cineole, and bornylacetate as the main constituents. The antioxidant capacity of three different extracts with increasing polarity and of the essential oil was evaluated by employing ABTS\u00b7+ and DPPH\u00b7 radical scavenging assays. The methanolic extract was the only significantly effective sample against both synthetic radicals. All samples were also tested against Gram-positive (Bacillus cereus, Enterococcus faecalis, Staphylococcus aureus) and Gram-negative (Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa) bacterial species using the disk diffusion assay. The non-polar extracts (dichloromethane and petroleum ether) and the essential oil possessed a broad spectrum of antimicrobial activity expressed according to inhibition zone diameter (8\u201324 mm).<\/jats:p>","DOI":"10.3390\/molecules21070830","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T12:56:01Z","timestamp":1467032161000},"page":"830","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Chemical Profile, Antioxidant and Antibacterial Activities of Achillea moschata Wulfen, an Endemic Species from the Alps"],"prefix":"10.3390","volume":"21","author":[{"given":"Sara","family":"Vitalini","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Agrarie ed Ambientali, Universit\u00e0 degli Studi di Milano, via G. Celoria 2, 20133 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moira","family":"Madeo","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina e Chirurgia, Universit\u00e0 degli Studi di Milano-Bicocca, Via Cadore 48, 20900 Monza, MB, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4657-4053","authenticated-orcid":false,"given":"Aldo","family":"Tava","sequence":"additional","affiliation":[{"name":"Consiglio per la Ricerca in Agricoltura e l\u2019Analisi dell\u2019Economia Agraria\u2014Centro di Ricerca per le Produzioni Foraggere e Lattiero Casearie (CREA-FLC), viale Piacenza 29, 26900 Lodi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5063-1236","authenticated-orcid":false,"given":"Marcello","family":"Iriti","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Agrarie ed Ambientali, Universit\u00e0 degli Studi di Milano, via G. Celoria 2, 20133 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Vallone","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Veterinarie per la Salute, la Produzione Animale e la Sicurezza Alimentare Universit\u00e0 degli Studi di Milano, via Grasselli 7, 20137 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinarosa","family":"Avato","sequence":"additional","affiliation":[{"name":"Dipartimento di Farmacia-Scienze del Farmaco, Universit\u00e0 degli Studi di Bari \u201cAldo Moro\u201d, via Orabona 4, 70125 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clementina","family":"Cocuzza","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina e Chirurgia, Universit\u00e0 degli Studi di Milano-Bicocca, Via Cadore 48, 20900 Monza, MB, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Simonetti","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze per gli Alimenti, la Nutrizione e l\u2019Ambiente, Universit\u00e0 degli Studi di Milano, via G. Celoria 2, 20133 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Argentieri","sequence":"additional","affiliation":[{"name":"Dipartimento di Farmacia-Scienze del Farmaco, Universit\u00e0 degli Studi di Bari \u201cAldo Moro\u201d, via Orabona 4, 70125 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1095-8339.2006.00541.x","article-title":"Karyological notes on eight species of Achillea L. (Asteraceae, Santolinoideae) from Turkey","volume":"151","author":"Sahin","year":"2006","journal-title":"Bot. J. Linn. Soc."},{"key":"ref_2","first-page":"173","article-title":"A review on Phytochemistry and medicinal properties of the genus Achillea","volume":"19","author":"Saeidnia","year":"2011","journal-title":"Daru"},{"key":"ref_3","unstructured":"Pignatti, S. (1982). 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