{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:44:31Z","timestamp":1790793871867,"version":"4.1.0"},"reference-count":287,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T00:00:00Z","timestamp":1467072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)"},{"name":"MCTI\/SETI\/Funda\u00e7\u00e3o Arauc\u00e1ria and Parana State Government"},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this review, we discuss the importance of capsaicin to the current understanding of neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We will focus on the analgesic effects of capsaicin and its clinical applicability in treating pain. Furthermore, we will draw attention to the rationale for other clinical therapeutic uses and implications of capsaicin in diseases such as obesity, diabetes, cardiovascular conditions, cancer, airway diseases, itch, gastric, and urological disorders.<\/jats:p>","DOI":"10.3390\/molecules21070844","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T06:20:33Z","timestamp":1467181233000},"page":"844","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":438,"title":["Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4565-7706","authenticated-orcid":false,"given":"Victor","family":"Fattori","sequence":"first","affiliation":[{"name":"Departamento de Ci\u00eancias Patol\u00f3gicas, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Hohmann","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Patol\u00f3gicas, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5711-818X","authenticated-orcid":false,"given":"Ana","family":"Rossaneis","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Patol\u00f3gicas, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Pinho-Ribeiro","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Patol\u00f3gicas, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldiceu","family":"Verri","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Patol\u00f3gicas, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.bmcl.2015.12.103","article-title":"New approaches to treating pain","volume":"26","author":"Wolkerstorfer","year":"2016","journal-title":"Bioorg. 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