{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:43:48Z","timestamp":1778795028308,"version":"3.51.4"},"reference-count":48,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T00:00:00Z","timestamp":1467849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Basic Science Research Program through the National Research Foundation of Korea","award":["NRF-2014R1A1A2056899"],"award-info":[{"award-number":["NRF-2014R1A1A2056899"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Adina rubella Hance (AR), a plant native to Korea, has been used as traditional medicine for dysentery, eczema, intoxication, and external hemorrhages. Previous phytochemical studies of AR have reported several components, including terpenoids, phenolics, and alkaloids. The current study evaluated the anti-oxidative and anti-inflammatory activities and 5\u03b1-reductase inhibition of isolated compounds of AR leaves to find a potential therapeutic agent for benign prostatic hypertrophy (BPH). Repeated chromatographic isolation of an 80% acetone extract of AR leaves yielded seven phenolic compounds: caffeic acid (1), chlorogenic acid (2), methyl chlorogenate (3), quercetin-3-rutinoside (4), kaempferol-3-O-\u03b1-l-rhamnopyranosyl-(1\u21926)-\u03b2-d-glucopyranoside (5), hyperoside (6), and grandifloroside (7). Compound 7 is a novel compound in AR. Caffeoyl derivatives 1\u20133 and 7 showed good anti-oxidative activities. In particular, caffeic acid (1) and grandifloroside (7) showed potent anti-inflammatory activities, and 7 also exhibited potent inhibitory activity against TNF-\u03b1 and 5\u03b1-reductase. Our results show that the extract and grandifloroside (7) from leaves of AR might be developed as a source of potent anti-oxidative and anti-inflammatory agents and therapeutic agent for BPH.<\/jats:p>","DOI":"10.3390\/molecules21070887","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T09:49:06Z","timestamp":1467884946000},"page":"887","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Inhibitory Activities of Phenolic Compounds Isolated from Adina rubella Leaves Against 5\u03b1-Reductase Associated with Benign Prostatic Hypertrophy"],"prefix":"10.3390","volume":"21","author":[{"given":"Jun","family":"Yin","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Heo","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon","family":"Hwang","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi","family":"Le","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,7,7]]},"reference":[{"key":"ref_1","first-page":"499","article-title":"Studies on chemical constituents of Adina rubella Hance (I)","volume":"25","author":"Lin","year":"1994","journal-title":"J. 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