{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:36:41Z","timestamp":1777351001787,"version":"3.51.4"},"reference-count":42,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T00:00:00Z","timestamp":1470096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"IGA VFU Brno","award":["302\/2015\/FaF"],"award-info":[{"award-number":["302\/2015\/FaF"]}]},{"name":"Ministry of Education, Youth and Sports of the Czech Republic from the National Programme of Sustainability (NPU II)","award":["LQ1602"],"award-info":[{"award-number":["LQ1602"]}]},{"name":"Ministry of Education, Youth and Sports of the Czech Republic","award":["SP2016\/85"],"award-info":[{"award-number":["SP2016\/85"]}]},{"DOI":"10.13039\/501100005357","name":"Slovak Research and Development Agency","doi-asserted-by":"publisher","award":["APVV-0516-12"],"award-info":[{"award-number":["APVV-0516-12"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Nanoparticles can be considered as a useful tool for improving properties of poorly soluble active ingredients. Hydrochlorothiazide (Class IV of the Biopharmaceutical Classification System) was chosen as a model compound. Antisolvent precipitation-solvent evaporation and emulsion solvent evaporation methods were used for preparation of 18 samples containing hydrochlorothiazide nanoparticles. Water solutions of surfactants sodium dodecyl sulfate, Tween 80 and carboxymethyl dextran were used in mass concentrations of 1%, 3% and 5%. Acetone and dichloromethane were used as solvents of the model compound. The particle size of the prepared samples was measured by dynamic light scattering. The selected sample of hydrochlorothiazide nanoparticles stabilized with carboxymethyl dextran sodium salt with particle size 2.6 nm was characterized additionally by Fourier transform mid-infrared spectroscopy and scanning electron microscopy. It was found that the solubility of this sample was 6.5-fold higher than that of bulk hydrochlorothiazide.<\/jats:p>","DOI":"10.3390\/molecules21081005","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T03:47:39Z","timestamp":1470196059000},"page":"1005","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Preparation of Hydrochlorothiazide Nanoparticles for Solubility Enhancement"],"prefix":"10.3390","volume":"21","author":[{"given":"Eliska","family":"Vaculikova","sequence":"first","affiliation":[{"name":"Nanotechnology Centre, VSB\u2014Technical University of Ostrava, 17. listopadu 15\/2172, 708 33 Ostrava, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aneta","family":"Cernikova","sequence":"additional","affiliation":[{"name":"Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1\/3, 612 42 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Placha","sequence":"additional","affiliation":[{"name":"Nanotechnology Centre, VSB\u2014Technical University of Ostrava, 17. listopadu 15\/2172, 708 33 Ostrava, Czech Republic"},{"name":"IT4 Innovations Centrum Excellence, VSB\u2014Technical University of Ostrava, 17. listopadu 15\/2172, 708 33 Ostrava, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Pisarcik","sequence":"additional","affiliation":[{"name":"Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Kalinciakova 8, 832 32 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavlina","family":"Peikertova","sequence":"additional","affiliation":[{"name":"Nanotechnology Centre, VSB\u2014Technical University of Ostrava, 17. listopadu 15\/2172, 708 33 Ostrava, Czech Republic"},{"name":"IT4 Innovations Centrum Excellence, VSB\u2014Technical University of Ostrava, 17. listopadu 15\/2172, 708 33 Ostrava, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Dedkova","sequence":"additional","affiliation":[{"name":"Nanotechnology Centre, VSB\u2014Technical University of Ostrava, 17. listopadu 15\/2172, 708 33 Ostrava, Czech Republic"},{"name":"Regional Materials Science and Technology Centre, VSB\u2014Technical University of Ostrava, 17. listopadu 15\/2172, 708 33 Ostrava, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-9994","authenticated-orcid":false,"given":"Ferdinand","family":"Devinsky","sequence":"additional","affiliation":[{"name":"Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Kalinciakova 8, 832 32 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2003-9052","authenticated-orcid":false,"given":"Josef","family":"Jampilek","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Odbojarov 10, 832 32 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,8,2]]},"reference":[{"key":"ref_1","unstructured":"Drug bank-Hydrochlorothiazide. 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