{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:19:23Z","timestamp":1790662763733,"version":"4.1.0"},"reference-count":53,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2016,8,13]],"date-time":"2016-08-13T00:00:00Z","timestamp":1471046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Erigeron floribundus (Asteraceae) is an herbaceous plant widely used in Cameroonian traditional medicine to treat various diseases of microbial and non-microbial origin. In the present study, we evaluated the in vitro biological activities displayed by the essential oil obtained from the aerial parts of E. floribundus, namely the antioxidant, antimicrobial and antiproliferative activities. Moreover, we investigated the inhibitory effects of E. floribundus essential oil on nicotinate mononucleotide adenylyltransferase (NadD), a promising new target for developing novel antibiotics, and Trypanosoma brucei, the protozoan parasite responsible for Human African trypanosomiasis. The essential oil composition was dominated by spathulenol (12.2%), caryophyllene oxide (12.4%) and limonene (8.8%). The E. floribundus oil showed a good activity against Staphylococcus aureus (inhibition zone diameter, IZD of 14 mm, minimum inhibitory concentration, MIC of 512 \u00b5g\/mL). Interestingly, it inhibited the NadD enzyme from S. aureus (IC50 of 98 \u00b5g\/mL), with no effects on mammalian orthologue enzymes. In addition, T. brucei proliferation was inhibited with IC50 values of 33.5 \u00b5g\/mL with the essential oil and 5.6 \u00b5g\/mL with the active component limonene. The essential oil exhibited strong cytotoxicity on HCT 116 colon carcinoma cells with an IC50 value of 14.89 \u00b5g\/mL, and remarkable ferric reducing antioxidant power (tocopherol-equivalent antioxidant capacity, TEAC = 411.9 \u03bcmol\u00b7TE\/g).<\/jats:p>","DOI":"10.3390\/molecules21081065","type":"journal-article","created":{"date-parts":[[2016,8,15]],"date-time":"2016-08-15T09:47:20Z","timestamp":1471254440000},"page":"1065","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Biological Activities of the Essential Oil from Erigeron floribundus"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4760-1204","authenticated-orcid":false,"given":"Riccardo","family":"Petrelli","sequence":"first","affiliation":[{"name":"School of Pharmacy, University of Camerino, Camerino 62032, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Orsomando","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Section of Biochemistry, Polytechnic University of Marche, Ancona 60131, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Sorci","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Section of Biochemistry, Polytechnic University of Marche, Ancona 60131, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1375-4744","authenticated-orcid":false,"given":"Filippo","family":"Maggi","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Camerino, Camerino 62032, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farahnaz","family":"Ranjbarian","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Biophysics, Ume\u00e5 University, Ume\u00e5 90187, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prosper","family":"Biapa Nya","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal Plant Biochemistry, Food Science and Nutrition, Department of Biochemistry, Faculty of Sciences, University of Dschang, PO Box 67, Dschang, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezemona","family":"Petrelli","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino, Camerino 62032, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Vitali","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Camerino, Camerino 62032, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Lupidi","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Camerino, Camerino 62032, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana","family":"Quassinti","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Camerino, Camerino 62032, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Bramucci","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Camerino, Camerino 62032, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Hofer","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Biophysics, Ume\u00e5 University, Ume\u00e5 90187, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8155-7211","authenticated-orcid":false,"given":"Loredana","family":"Cappellacci","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Camerino, Camerino 62032, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,8,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jep.2004.01.010","article-title":"Analgesic and antinflammatory activities of Erigeron floribundus","volume":"91","author":"Asongalem","year":"2004","journal-title":"J. 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