{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T22:41:03Z","timestamp":1768084863976,"version":"3.49.0"},"reference-count":30,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T00:00:00Z","timestamp":1476316800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81502951"],"award-info":[{"award-number":["81502951"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Three new butenolides aspernolides H\u2013J (1\u20133) together with seven known ones (4\u201310) were isolated from the fungus Aspergillus sp. CBS-P-2. Their chemical structures were established on the basis of 1D- and 2D-NMR spectroscopic data, HR-ESI-MS analysis, and their absolute configuration were determined by circular dichroism (CD) analysis. All the compounds were evaluated for the antioxidant effects by DPPH and ABTS methods, the antitumor activities against four human tumor cell lines (HL-60, ASPC1, HCT-116 and PC-3) and antimicrobial activities. Compounds 4\u201310 showed significant activity against DPPH (IC50 = 15.9\u201334.3 \u03bcM) and compounds 1\u201310 exhibited significant ABTS free radical scavenging activity (IC50 = 2.8\u201333.1 \u03bcM). Compounds 2, 5 and 11 showed potent cytotoxic activities against HL-60 cell lines with IC50 values of 39.4, 13.2 and 16.3 \u03bcM, respectively. Compound 10 showed good antimicrobial activity against Staphylococcus aureus with minimum inhibitory concentration (MIC) of 21.3 \u03bcM.<\/jats:p>","DOI":"10.3390\/molecules21101361","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T10:33:10Z","timestamp":1476354790000},"page":"1361","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Three New Butenolides from the Fungus Aspergillus sp. CBS-P-2"],"prefix":"10.3390","volume":"21","author":[{"given":"Xiao","family":"An","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China"},{"name":"Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuehu","family":"Pei","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China"},{"name":"Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaofei","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China"},{"name":"Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengge","family":"Li","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China"},{"name":"Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolong","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China"},{"name":"Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China"},{"name":"Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Lin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"},{"name":"Department of Medicinal Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2344-1066","authenticated-orcid":false,"given":"Haifeng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China"},{"name":"Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,10,13]]},"reference":[{"key":"ref_1","first-page":"12","article-title":"Discovery of new bioactive natural products from fungi of unique ecological niches","volume":"38","author":"Che","year":"2011","journal-title":"J. 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