{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T11:06:20Z","timestamp":1769943980280,"version":"3.49.0"},"reference-count":50,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T00:00:00Z","timestamp":1477440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Lodz","award":["503\/3-014-1\/503-01"],"award-info":[{"award-number":["503\/3-014-1\/503-01"]}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["GOA 15\/19 TBA"],"award-info":[{"award-number":["GOA 15\/19 TBA"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A novel series of diethyl {4-[(5-substituted-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-methyl]-1H-1,2,3-triazol-1-yl}alkylphosphonates designed as analogues of amonafide was synthesized. All phosphonates were assessed for antiviral activity against a broad range of DNA and RNA viruses and several of them showed potency against varicella-zoster virus (VZV) [EC50 (50% effective concentration) = 27.6\u201391.5 \u03bcM]. Compound 16b exhibited the highest activity against a thymidine kinase-deficient (TK\u2212) VZV strain (EC50 = 27.59 \u03bcM), while 16d was the most potent towards TK+ VZV (EC50 = 29.91 \u03bcM). Cytostatic properties of the compounds 14a\u2013i\u201317a\u2013i were studied on L1210, CEM, HeLa and HMEC-1 cell lines and most of them were slightly cytostatic for HeLa [IC50 (50% inhibitory concentration) = 29\u2013130 \u00b5M] and L1210 cells [IC50 (50% inhibitory concentration) = 14\u2013142 \u00b5M].<\/jats:p>","DOI":"10.3390\/molecules21111420","type":"journal-article","created":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T10:12:01Z","timestamp":1477476721000},"page":"1420","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Synthesis and the Biological Activity of Phosphonylated 1,2,3-Triazolenaphthalimide Conjugates"],"prefix":"10.3390","volume":"21","author":[{"given":"Iwona","family":"G\u0142owacka","sequence":"first","affiliation":[{"name":"Bioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, Muszy\u0144skiego 1, 90-151 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafa\u0142","family":"Gulej","sequence":"additional","affiliation":[{"name":"Bioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, Muszy\u0144skiego 1, 90-151 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Grzonkowski","sequence":"additional","affiliation":[{"name":"Bioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, Muszy\u0144skiego 1, 90-151 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graciela","family":"Andrei","sequence":"additional","affiliation":[{"name":"Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Schols","sequence":"additional","affiliation":[{"name":"Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Snoeck","sequence":"additional","affiliation":[{"name":"Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorota","family":"Piotrowska","sequence":"additional","affiliation":[{"name":"Bioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, Muszy\u0144skiego 1, 90-151 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,10,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cclet.2013.12.017","article-title":"An eco-friendly water mediated synthesis of 1,2,3-triazolyl-2-aminopyrimidine hybrids as highly potent anti-bacterial agents","volume":"25","author":"Nagarajan","year":"2014","journal-title":"Chin. 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