{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:37:08Z","timestamp":1787650628559,"version":"build-2736575974"},"reference-count":20,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T00:00:00Z","timestamp":1477872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Embothrium coccineum J.R. Forst. &amp; G. Forst is an evergreen tree that has been used as a folk remedy for the treatment of neuralgia, tooth pains, wound healing, and glandular conditions, as well as an antiseptic agent against bacterial infection. The antibacterial activities of sequential extracts (hexane, dichloromethane, ethyl acetate, and ethanol) from the leaves of E. coccineum were evaluated by means of the micro-dilution assay against six (Escherichia coli; Klebsiella pneumoniae; Proteus mirabilis; Pseudomonas aeruginosa; Staphylococcus aureus and Streptococcus pyogenes) multiresistant bacteria strains. Ethyl acetate extract showed the best spectra of antibacterial activity against all tested bacteria, and was analyzed by gas chromatography\u2013mass spectrometry (GC-MS) for its composition. The results of the present work provide useful baseline information for the potential development and use of nanoparticles and\/or nanofibers doped with extracts of E. coccineum in the fight against multiresistant bacteria, which would allow the validation of the traditional use of E. coccineum by native peoples of Patagonia as an antimicrobial agent in the biomedical Field.<\/jats:p>","DOI":"10.3390\/molecules21111441","type":"journal-article","created":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T11:09:46Z","timestamp":1477912186000},"page":"1441","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["In Vitro Antimicrobial Activity of Embothrium coccineum Used as Traditional Medicine in Patagonia against Multiresistant Bacteria"],"prefix":"10.3390","volume":"21","author":[{"given":"Nicole","family":"Canales","sequence":"first","affiliation":[{"name":"Escuela de Tecnolog\u00eda M\u00e9dica Facultad de Ciencias de la Salud, Universidad Central de Chile, Edificio Gonzalo Hern\u00e1ndez Uribe, Lord Cochrane 417, Santiago Centro 8320000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"Montenegro","sequence":"additional","affiliation":[{"name":"Escuela de Obstetricia y Puericultura, Facultad de medicina, Campus de la Salud, Universidad de Valpara\u00edso, Angamos 655, Re\u00f1aca, Vi\u00f1a del Mar 2520000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"P\u00e1rraga","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biom\u00e9dicas (CIB), Escuela de Medicina, Universidad de Valpara\u00edso, Av. Hontaneda No. 2664, Valpara\u00edso 2340000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusser","family":"Olgu\u00edn","sequence":"additional","affiliation":[{"name":"Center for Integrative Medicine and Innovative Science (CIMIS), Facultad de Medicina, Universidad Andr\u00e9s Bello, Santiago 8320000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricio","family":"Godoy","sequence":"additional","affiliation":[{"name":"Instituto de Microbiolog\u00eda Cl\u00ednica, Facultad de Medicina, Universidad Austral de Chile, Los Laureles s\/n, Isla Teja, Valdivia 5090000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Werner","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias B\u00e1sicas, Campus Fernando May Universidad del Biob\u00edo, Avda. Andr\u00e9s Bello s\/n casilla 447, Chill\u00e1n 3780000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Madrid","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Avda. Leopoldo Carvallo 270, Playa Ancha, Valpara\u00edso 2340000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,10,31]]},"reference":[{"key":"ref_1","unstructured":"Donoso, C. (2006). Las especies arb\u00f3reas de los bosques templados de Argentina y Chile. Autoecolog\u00eda, Marisa Cuneo Ediciones. 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