{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:46:58Z","timestamp":1783615618119,"version":"3.55.0"},"reference-count":39,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T00:00:00Z","timestamp":1478649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81260664 and 81560597 to L.-H.Lian; 81360658 and 81660689 to J.-X.Nan)"],"award-info":[{"award-number":["81260664 and 81560597 to L.-H.Lian; 81360658 and 81660689 to J.-X.Nan)"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Planning Projects from the Science and Technology Department of Jilin Province","award":["20150520145JH and 20160101205JC L.-H.Lian"],"award-info":[{"award-number":["20150520145JH and 20160101205JC L.-H.Lian"]}]},{"name":"\u201cDouble Ten\u201d Cultivation Project from the Educational Commission of Jilin Province of China","award":["2014, to J.-X.Nan"],"award-info":[{"award-number":["2014, to J.-X.Nan"]}]},{"name":"Medical Scientific Research Foundation of Jilin Province of China","award":["20142090, to J.-X.Nan"],"award-info":[{"award-number":["20142090, to J.-X.Nan"]}]},{"name":"the Innovative Research Team Project of Key Laboratory at Yanbian University","award":["J.-X.Nan"],"award-info":[{"award-number":["J.-X.Nan"]}]},{"name":"Outstanding Young Talent Cultivation Project of Key Laboratory at Yanbian University.","award":["NRFM-YF201602, to L.-H.Lian"],"award-info":[{"award-number":["NRFM-YF201602, to L.-H.Lian"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The current study was designed to investigate the anti-inflammatory effect of salidroside (SDS) and the underlying mechanism by using lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages in vitro and a mouse model of binge drinking-induced liver injury in vivo. SDS downregulated protein expression of toll-like receptor 4 (TLR4) and CD14. SDS inhibited LPS-triggered phosphorylation of LPS-activated kinase 1 (TAK1), p38, c-Jun terminal kinase (JNK), and extracellular signal-regulated kinase (ERK). Degradation of I\u03baB-\u03b1 and nuclear translocation of nuclear factor (NF)-\u03baB were effectively blocked by SDS. SDS concentration-dependently suppressed LPS mediated inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein levels, as well as their downstream products, NO. SDS significantly inhibited protein secretion and mRNA expression of of interleukin (IL)-1\u03b2 and tumor necrosis factor (TNF)-\u03b1. Additionally C57BL\/6 mice were orally administrated SDS for continuous 5 days, followed by three gavages of ethanol every 30 min. Alcohol binge drinking caused the increasing of hepatic lipid accumulation and serum transaminases levels. SDS pretreatment significantly alleviated liver inflammatory changes and serum transaminases levels. Further investigation indicated that SDS markedly decreased protein level of IL-1\u03b2 in serum. Taken together, these data implied that SDS inhibits liver inflammation both in vitro and in vivo, and may be a promising candidate for the treatment of inflammatory liver injury.<\/jats:p>","DOI":"10.3390\/molecules21111490","type":"journal-article","created":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T10:09:39Z","timestamp":1478686179000},"page":"1490","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Salidroside Regulates Inflammatory Response in Raw 264.7 Macrophages via TLR4\/TAK1 and Ameliorates Inflammation in Alcohol Binge Drinking-Induced Liver Injury"],"prefix":"10.3390","volume":"21","author":[{"given":"Peng","family":"Sun","sequence":"first","affiliation":[{"name":"Key Laboratory for Natural Resource of ChangBai Mountain &amp; Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China"},{"name":"Clinical Research Center, Yanbian University Hospital, Yanji 133002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-Zong","family":"Song","sequence":"additional","affiliation":[{"name":"Key Laboratory for Natural Resource of ChangBai Mountain &amp; Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Natural Resource of ChangBai Mountain &amp; Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory for Natural Resource of ChangBai Mountain &amp; Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Li","family":"Yao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Natural Resource of ChangBai Mountain &amp; Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ling","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Natural Resource of ChangBai Mountain &amp; Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Hua","family":"Lian","sequence":"additional","affiliation":[{"name":"Key Laboratory for Natural Resource of ChangBai Mountain &amp; Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6221-4309","authenticated-orcid":false,"given":"Ji-Xing","family":"Nan","sequence":"additional","affiliation":[{"name":"Key Laboratory for Natural Resource of ChangBai Mountain &amp; Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China"},{"name":"Clinical Research Center, Yanbian University Hospital, Yanji 133002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,11,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nri910","article-title":"NF-\u03baB regulation in the immune system","volume":"2","author":"Li","year":"2002","journal-title":"Nat. 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