{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T13:02:10Z","timestamp":1768827730098,"version":"3.49.0"},"reference-count":29,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008061","name":"Fundaci\u00f3n Mutua Madrile\u00f1a","doi-asserted-by":"publisher","award":["AP102962012"],"award-info":[{"award-number":["AP102962012"]}],"id":[{"id":"10.13039\/100008061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"MINECO","doi-asserted-by":"publisher","award":["SAF2011-28150"],"award-info":[{"award-number":["SAF2011-28150"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"MINECO","doi-asserted-by":"publisher","award":["SAF2014-55399"],"award-info":[{"award-number":["SAF2014-55399"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"MINECO","doi-asserted-by":"publisher","award":["SAF2014-58950R"],"award-info":[{"award-number":["SAF2014-58950R"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Background: We hypothesized that treatment with quercetin could result in improved hemodynamics, lung inflammatory parameters and mortality in a rat model of hemorrhagic shock. Methods: Rats were anesthetized (80 mg\/kg ketamine plus 8 mg\/kg xylazine i.p.). The protocol included laparotomy for 15 min (trauma), hemorrhagic shock (blood withdrawal to reduce the mean arterial pressure to 35 mmHg) for 75 min and resuscitation by re-infusion of all the shed blood plus lactate Ringer for 90 min. Intravenous quercetin (50 mg\/kg) or vehicle were administered during resuscitation. Results: There was a trend for increased survival 84.6% (11\/13) in the treated group vs. the shock group 68.4% (13\/19, p &gt; 0.05 Kaplan\u2013Meier). Quercetin fully prevented the development of lung edema. The activity of aSMase was increased in the shock group compared to the sham group and the quercetin prevented this effect. However, other inflammatory markers such as myeloperoxidase activity, interleukin-6 in plasma or bronchoalveolar fluid were similar in the sham and shock groups. We found no bacterial DNA in plasma in these animals. Conclusions: Quercetin partially prevented the changes in blood pressure and lung injury in shock associated to hemorrhage and reperfusion.<\/jats:p>","DOI":"10.3390\/molecules21121739","type":"journal-article","created":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T04:09:09Z","timestamp":1482466149000},"page":"1739","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effects of Quercetin in a Rat Model of Hemorrhagic Traumatic Shock and Reperfusion"],"prefix":"10.3390","volume":"21","author":[{"given":"Virginia","family":"Chamorro","sequence":"first","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad Complutense de Madrid, Madrid 28040, Spain"},{"name":"Centro de Investigaciones Biom\u00e9dicas en Red de Enfermedades Respiratorias (Ciberes), Madrid 28029, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IISGM), Madrid 28007, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachele","family":"Pandolfi","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad Complutense de Madrid, Madrid 28040, Spain"},{"name":"Centro de Investigaciones Biom\u00e9dicas en Red de Enfermedades Respiratorias (Ciberes), Madrid 28029, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IISGM), Madrid 28007, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Moreno","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad Complutense de Madrid, Madrid 28040, Spain"},{"name":"Centro de Investigaciones Biom\u00e9dicas en Red de Enfermedades Respiratorias (Ciberes), Madrid 28029, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IISGM), Madrid 28007, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"Barreira","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biom\u00e9dicas en Red de Enfermedades Respiratorias (Ciberes), Madrid 28029, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IISGM), Madrid 28007, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5680-3529","authenticated-orcid":false,"given":"Andrea","family":"Mart\u00ednez-Ramas","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biom\u00e9dicas en Red de Enfermedades Respiratorias (Ciberes), Madrid 28029, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IISGM), Madrid 28007, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1692-4633","authenticated-orcid":false,"given":"Daniel","family":"Morales-Cano","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad Complutense de Madrid, Madrid 28040, Spain"},{"name":"Centro de Investigaciones Biom\u00e9dicas en Red de Enfermedades Respiratorias (Ciberes), Madrid 28029, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IISGM), Madrid 28007, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Ruiz-Cabello","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biom\u00e9dicas en Red de Enfermedades Respiratorias (Ciberes), Madrid 28029, Spain"},{"name":"Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fern\u00e1ndez Almagro 3, Madrid 28029, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Lorente","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biom\u00e9dicas en Red de Enfermedades Respiratorias (Ciberes), Madrid 28029, Spain"},{"name":"Servicio de Medicina Intensiva, Hospital Universitario de Getafe, Getafe, Madrid 28905, Spain"},{"name":"Universidad Europea de Madrid, Madrid 28905, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Duarte","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Farmacia, Universidad de Granada, Granada 18071, Spain"},{"name":"Centro de Investigaciones Biom\u00e9dicas en Red de Enfermedades Cardiovasculares (Ciberec), Madrid 28029, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1382-1698","authenticated-orcid":false,"given":"\u00c1ngel","family":"Cogolludo","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad Complutense de Madrid, Madrid 28040, Spain"},{"name":"Centro de Investigaciones Biom\u00e9dicas en Red de Enfermedades Respiratorias (Ciberes), Madrid 28029, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IISGM), Madrid 28007, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Alvarez-Sala","sequence":"additional","affiliation":[{"name":"Departamento de Medicina, Facultad de Medicina, Universidad Complutense de Madrid, Madrid 28040, Spain"},{"name":"Servicio de Neumolog\u00eda, Instituto de Investigaci\u00f3n Sanitaria San Carlos (IdISSC), Madrid 28040, 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