{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:31:51Z","timestamp":1782235911671,"version":"3.54.5"},"reference-count":103,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Rubia cordifolia Linn (Rubiaceae) is a climbing perennial herbal plant, which is widely distributed in China and India. Its root and rhizome, Rubiae Radix et Rhizoma (called Qiancao in China and Indian madder in India), is a well known phytomedicine used for hematemesis, epistaxis, flooding, spotting, traumatic bleeding, amenorrhea caused by obstruction, joint impediment pain, swelling and pain caused by injuries from falls. In addition, it is a kind of pigment utilized as a food additive and a dye for wool or fiber. This review mainly concentrates on studies of the botany, phytochemistry, pharmacology and toxicology of this Traditional Chinese Medicine. The phytochemical evidences indicated that over a hundred chemical components have been found and isolated from the medicine, such as anthraquinones, naphthoquinones, triterpenoids, cyclic hexapeptides and others. These components are considered responsible for the various bioactivities of the herbal drug, including anti-oxidation, anti-inflammation, immunomodulation, antitumor, effects on coagulation-fibrinolysis system, neuroprotection and other effects. Additionally, based on these existing results, we also propose some interesting future research directions. Consequently, this review should help us to more comprehensively understand and to more fully utilize the herbal medicine Rubiae Radix et Rhizoma.<\/jats:p>","DOI":"10.3390\/molecules21121747","type":"journal-article","created":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T04:09:09Z","timestamp":1482466149000},"page":"1747","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["A Review of the Botany, Phytochemistry, Pharmacology and Toxicology of Rubiae Radix et Rhizoma"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3029-7074","authenticated-orcid":false,"given":"Mingqiu","family":"Shan","sequence":"first","affiliation":[{"name":"Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yan","sequence":"additional","affiliation":[{"name":"Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peidong","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwei","family":"Ding","sequence":"additional","affiliation":[{"name":"Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,12,20]]},"reference":[{"key":"ref_1","unstructured":"Chinese Pharmacopeia Commission (2015). Pharmacopoeia of the People\u2019s Republic of China, Chinese Medical Science Press."},{"key":"ref_2","first-page":"1945","article-title":"New anthraquinones from Rubia cordifolia roots","volume":"45","author":"Akhtar","year":"2006","journal-title":"Indian J. Chem. B"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"9673","DOI":"10.1016\/j.tet.2015.10.044","article-title":"Rubicordins A-C, new cyclopeptides from Rubia cordifolia with cytotoxicity and inhibiting NF-\u03baB signaling pathway","volume":"71","author":"Chen","year":"2015","journal-title":"Tetrahedron"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.phytol.2012.02.014","article-title":"O-Seco-RA-XXIV, a possible precursor of an antitumor peptide RA-XXIV, from Rubia cordifolia L.","volume":"5","author":"Hitotsuyanagi","year":"2012","journal-title":"Phytochem. Lett."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1002\/chem.201103185","article-title":"Isolation, structure determination, and synthesis of allo-RA-V and neo-RA-V, RA-series bicyclic peptides from Rubia cordifolia L.","volume":"18","author":"Hitotsuyanagi","year":"2012","journal-title":"Chem. Eur. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1248\/cpb.31.2353","article-title":"Studies on a novel anthraquinone and its glycosides isolated from Rubia cordifolia and R. akane","volume":"31","author":"Itokawa","year":"1983","journal-title":"Chem. Pharm. Bull."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1016\/0031-9422(89)80365-6","article-title":"Anthraquinones and naphthohydroquinones from Rubia cordifolia","volume":"28","author":"Itokawa","year":"1989","journal-title":"Phytochemistry"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1248\/cpb.41.1869","article-title":"Anthraquinones, naphthohydroquinones and naphthohydroquinone dimers from Rubia cordifolia and their cytotoxic activity","volume":"41","author":"Itokawa","year":"1993","journal-title":"Chem. Pharm. Bull."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"937","DOI":"10.2298\/JSC0507937S","article-title":"Isolation and synthesis of anthraquinones and related compounds of Rubia cordifolia","volume":"70","author":"Singh","year":"2005","journal-title":"J. Serbian Chem. Soc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/0031-9422(81)84036-8","article-title":"Two pentacyclic triterpenes from Rubia cordifolia","volume":"20","author":"Talapatra","year":"1981","journal-title":"Phytochemistry"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1042\/BJ20111661","article-title":"Macromolecular and small-molecule modulation of intracellular A beta(42)aggregationand associated toxicity","volume":"442","author":"Chakrabortee","year":"2012","journal-title":"Biochem. J."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Deoda, R.S., Kumar, D., and Bhujbal, S.S. (2011). Gastroprotective effect of Rubia cordifolia Linn on aspirin plus pylorus-ligated ulcer. Evid. Based Complement. Altern. Med.","DOI":"10.1155\/2011\/541624"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"441","DOI":"10.4103\/0253-7613.83118","article-title":"The protective effect of Rubia cordifolia against lead nitrate-induced immune response impairment and kidney oxidative damage","volume":"43","author":"Lodi","year":"2011","journal-title":"Indian J. Pharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Lopez-Exposito, I., Castillo, A., Yang, N., Liang, B.H., and Li, X.M. (2011). Chinese herbal extracts of Rubia cordifolia and Dianthus superbus suppress IgE production and prevent peanut-induced anaphylaxis. Chin. Med.","DOI":"10.1186\/1749-8546-6-35"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.7314\/APJCP.2012.13.6.2753","article-title":"Induction of apoptosis by methanolic extract of Rubia Cordifolia Linn in HEp-2 cell line is mediated by reactive oxygen species","volume":"13","author":"Shilpa","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3109\/13880209.2011.608073","article-title":"Ameliorative effect of methanol extract of Rubia cordifolia in N-nitrosodiethylamine-induced hepatocellular carcinoma","volume":"50","author":"Shilpa","year":"2012","journal-title":"Pharm. Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1248\/bpb.b12-00804","article-title":"Mollugin inhibits the inflammatory response in lipopolysaccharide-stimulated RAW264.7 macrophages by blocking the Janus kinase-signal transducers and activators of transcription signaling pathway","volume":"36","author":"Zhu","year":"2013","journal-title":"Biol. Pharm. Bull."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1478-4408.2001.tb00084.x","article-title":"Dyeing studies with hydroxyanthraquinones extracted from Indian madder. Part 1: Dyeing of nylon with purpurin","volume":"117","author":"Gupta","year":"2001","journal-title":"Color. Technol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1478-4408.2001.tb00085.x","article-title":"Dyeing studies with hydroxyanthraquinones extracted from Indian madder. Part 2: Dyeing of nylon and polyester with nordamncanthal","volume":"117","author":"Gupta","year":"2001","journal-title":"Color. Technol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.dyepig.2006.08.023","article-title":"Ecofriendly sonicator dyeing of cotton with Rubia cordifolia Linn using biomordant","volume":"76","author":"Vankar","year":"2008","journal-title":"Dyes Pigment"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1080\/15440478.2012.738026","article-title":"Eco-dyeing of wool using aqueous extract of the roots of Indian Madder (Rubia cordifolia) as natural dye","volume":"10","author":"Yusuf","year":"2013","journal-title":"J. Nat. Fibers"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Namsa, N.D., Mandal, M., Tangjang, S., and Mandal, S.C. (2011). Ethnobotany of the Monpa ethnic group at Arunachal Pradesh, India. J. Ethnobiol. Ethnomed.","DOI":"10.1186\/1746-4269-7-31"},{"key":"ref_23","unstructured":"Xun, L. (2014). Quality Control Study of Rubia cordifolia L. and the Fakes. [Master\u2019s Thesis, Beijing University of Chinese Medicine]."},{"key":"ref_24","unstructured":"State Administration of Traditional Chinese Medicine (1998). Chinese Materia Medica."},{"key":"ref_25","first-page":"7","article-title":"A study on the medicinal plants of genus Rubia. I. Botanical origins and resource of Chinese traditional drug \u201cQiancao\u201d (Madder)","volume":"3","author":"Chen","year":"1991","journal-title":"Nat. Prod. Res. Dev."},{"key":"ref_26","first-page":"2069","article-title":"Rubiatriol, a new triterpenoid from the Chinese drug, Qian-Cao-Gen, Rubia cordifolia","volume":"74","author":"Arisawa","year":"1986","journal-title":"J. Nat. Prod."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s13744-016-0386-x","article-title":"Larvicidal and pupicidal activities of alizarin isolated from roots of Rubia cordifolia against Culex quinquefasciatus Say and Aedes aegypti (L.) (Diptera: Culicidae)","volume":"45","author":"Gandhi","year":"2016","journal-title":"Neotrop. Entomol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/S0031-9422(00)90136-5","article-title":"Anthraquinones of Rubia cordifolia","volume":"11","author":"Murti","year":"1972","journal-title":"Phytochemistry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1248\/cpb.56.213","article-title":"Anticancer Constituents from the Roots of Rubia cordifolia L.","volume":"56","author":"Son","year":"2008","journal-title":"Chem. Pharm. Bull."},{"key":"ref_30","first-page":"743","article-title":"Study on anthraquinones from the roots of Rubia cordifolia L.","volume":"27","author":"Wang","year":"1992","journal-title":"Acta Pharm. Sin."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0367-326X(99)00085-4","article-title":"Anthraquinone production by callus cultures of Rubia cordifolia","volume":"70","author":"Mischenko","year":"1999","journal-title":"Fitoterapia"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1055\/s-2007-971724","article-title":"New anthraquinones in Rubia cordifolia roots","volume":"41","author":"Tessier","year":"1981","journal-title":"Planta Med."},{"key":"ref_33","first-page":"1126","article-title":"Study on the chemical constituents and anticancer activity from the roots of Rubia cordifolia L.","volume":"32","author":"Jiang","year":"2012","journal-title":"Chin. Hosp. Pharm. J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3390\/molecules14010566","article-title":"Rubiacordone A: A new anthraquinone glycoside from the roots of Rubia cordifolia","volume":"14","author":"Li","year":"2009","journal-title":"Molecules"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1055\/s-2007-971524","article-title":"New quinones in Rubia cordifolia L. Roots, III","volume":"43","author":"Dosseh","year":"1981","journal-title":"Planta Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1016\/0031-9422(92)83662-I","article-title":"Two naphthoquinones from Rubia cordifolia","volume":"31","author":"Koyama","year":"1992","journal-title":"Phytochemistry"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1365\/s10337-008-0629-z","article-title":"Simultaneous isolation and purification of mollugin and two anthraquinones from Rubia cordifolia by HSCCC","volume":"68","author":"Liu","year":"2008","journal-title":"Chromatographia"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1002\/jssc.201000173","article-title":"Preparative separation of anti-oxidative constituents from Rubia cordifolia by column-switching counter-current chromatography","volume":"33","author":"Lu","year":"2010","journal-title":"J. Sep. Sci."},{"key":"ref_39","first-page":"857","article-title":"Study of anthraquinone components from rhizome of Rubia cordifolia by preparative chromatogram of medium and low press","volume":"31","author":"Lin","year":"2011","journal-title":"Guihaia"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1055\/s-2007-971490","article-title":"Rubia cordifolia roots. II: New quinones","volume":"43","author":"Dosseh","year":"1981","journal-title":"Planta Med."},{"key":"ref_41","unstructured":"Wang, J.J. (2014). Study on the Chemical and Biological Activity of Rubia cordifolia L. Collected from Henan Province. [Master\u2019s Thesis, Henan University]."},{"key":"ref_42","first-page":"216","article-title":"Two new anthraquinones from the roots of Rubia cordifolia Linn","volume":"58","author":"Abdullah","year":"2003","journal-title":"Pharmazie"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.5012\/bkcs.2006.27.8.1231","article-title":"DNA Topoisomerases I and II inhibition and cytotoxicity of constituents from the roots of Rubia cordifolia","volume":"27","author":"Son","year":"2006","journal-title":"Bull. Korean Chem. Soc."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1076\/phbi.37.1.46.6322","article-title":"Biological activity of Rubia cordifolia and isolation of an active principle","volume":"37","author":"Gupta","year":"1999","journal-title":"Pharm. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1021\/np960200h","article-title":"Inhibition of hepatitis B surface antigen secretion on human hepatoma cells. Components from Rubia cordifolia","volume":"59","author":"Ho","year":"1996","journal-title":"J. Nat. Prod."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/0031-9422(91)84241-J","article-title":"6-Methoxygeniposidic acid, an iridoid glycoside from Rubia cordifolia","volume":"30","author":"Wu","year":"1991","journal-title":"Phytochemistry"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1089\/jmf.2010.1385","article-title":"Anti-adipogenic activity of 2-carbomethoxy-2,3-epoxy-3-prenyl-1,4-naphthoquinone from Rubia cordifolia L.","volume":"14","author":"Jun","year":"2011","journal-title":"J. Med. Food"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.1248\/cpb.34.3762","article-title":"Studies on antitumor cyctic hexapeptides RA obtained from Rubiae Radix, Rubiaceae.VI. Minor antitumor constituents","volume":"34","author":"Itokawa","year":"1986","journal-title":"Chem. Pharm. Bull."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"7007","DOI":"10.1016\/S0040-4020(01)96155-1","article-title":"New antitumor bicyclic hexapeptides, RA-VI and RA-VIII from Rubia cordifolia-conformation-activity relationship II","volume":"47","author":"Itokawa","year":"1991","journal-title":"Tetrahedron"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1039\/P19920000455","article-title":"New antitumour bicyclic hexapeptides, RA-IX and -X from Rubia cordifolia. Part 3. Conformation-antitumour activity relationship","volume":"14","author":"Itokawa","year":"1992","journal-title":"J. Chem. Soc. Perkin Trans."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1248\/cpb.40.1352","article-title":"New antitumor bicyclic hexapeptides, RA-XI, RA-XII, RA-XIII and RA-XIV from Rubia cordifolia","volume":"40","author":"Morita","year":"1992","journal-title":"Chem. Pharm. Bull."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0031-9422(93)85458-4","article-title":"Two antitumour bicyclic hexapeptides from Rubia cordifolia","volume":"33","author":"Takeya","year":"1993","journal-title":"Phytochemistry"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.tetlet.2003.11.112","article-title":"Isolation, structural elucidation, and synthesis of RA-XVII, a novel bicyclic hexapeptide from Rubia cordifolia, and the effect of side chain at residue 1 upon the conformation and cytotoxic activity","volume":"45","author":"Hitotsuyanagi","year":"2004","journal-title":"Tetrahedron Lett."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.bmcl.2007.11.030","article-title":"A novel bicyclic hexapeptide, RA-XVIII, from Rubia cordifolia: Structure, semi-synthesis, and cytotoxicity","volume":"18","author":"Lee","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1016\/j.tet.2008.01.094","article-title":"Structures of cytotoxic bicyclic hexapeptides, RA-XIX, -XX, -XXI, and -XXII, from Rubia cordifolia L.","volume":"64","author":"Lee","year":"2008","journal-title":"Tetrahedron"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1248\/cpb.56.730","article-title":"New cytotoxic bicyclic hexapeptides, RA-XXIII and XXIV, from Rubia cordifolia L.","volume":"56","author":"Lee","year":"2008","journal-title":"Chem. Pharm. Bull."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1246\/cl.1991.2217","article-title":"RAI-III and VI, Conformational isomers of antitumor cyclic hexapeptides, RA-III and VI from Rubia cordifolia","volume":"12","author":"Itokawa","year":"1991","journal-title":"Chem. Lett."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"6127","DOI":"10.1016\/S0040-4039(00)01029-7","article-title":"RA-dimer A, a novel dimeric antitumor bicyclic hexapeptide from Rubia cordifolia L.","volume":"41","author":"Hitotsuyanagi","year":"2000","journal-title":"Tetrahedron Lett."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1248\/cpb.38.1435","article-title":"New arborane type triterpenoids from Rubia cordifolia var Pratensis and Rubia oncotricha","volume":"38","author":"Itokawa","year":"1990","journal-title":"Chem. Pharm. Bull."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1248\/cpb.37.1670","article-title":"New triterpenoids from Rubiacordifolia var Pratensis (Rubiaceae)","volume":"37","author":"Itokawa","year":"1989","journal-title":"Chem. Pharm. Bull."},{"key":"ref_61","first-page":"225","article-title":"Minor constituents from Rubia cordifolia L. root","volume":"33","author":"Ibraheim","year":"2010","journal-title":"Bull. Pharm. Sci."},{"key":"ref_62","first-page":"58","article-title":"Structure identification of a new iridoid glycoside from Rubia cordifolia","volume":"46","author":"Wang","year":"1991","journal-title":"J. Shenyang Coll. Pharm."},{"key":"ref_63","first-page":"317","article-title":"Further quinoidal derivatives from Rubia cordifolia L.","volume":"55","author":"Hassanean","year":"2000","journal-title":"Pharmazie"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"7157","DOI":"10.1016\/S0040-4039(00)01205-3","article-title":"Rubiasins A-C, new anthracene derivatives from the roots and stems of Rubia cordifolia","volume":"41","author":"Chang","year":"2000","journal-title":"Tetrahedron Lett."},{"key":"ref_65","first-page":"25","article-title":"Studies on the constituents of polysaccharides RPS-1, RPS-2 and RPS-3 from R. cordifolia","volume":"19","author":"Huang","year":"1996","journal-title":"Chin. Tradit. Patent Med."},{"key":"ref_66","first-page":"219","article-title":"Isolation, purification and structural analysis of polysaccharide QA2 from Indian Madder (Rubia cordifolia)","volume":"29","author":"Wang","year":"1998","journal-title":"Chin. Tradit Herb. Drugs"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.bbrc.2014.06.017","article-title":"Purpurin inhibits adipocyte-derived leucineaminopeptidase and angiogenesis in a zebrafish model","volume":"450","author":"Park","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00706-011-0695-z","article-title":"Antioxidant and free radical scavenging activity of purpurin","volume":"143","author":"Jeremic","year":"2012","journal-title":"Monatshefte Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1177\/0960327115595687","article-title":"Evaluation of antioxidant, enzyme inhibition, and cytotoxic activity of three anthraquinones (alizarin, purpurin, and quinizarin)","volume":"35","author":"Zengin","year":"2016","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1002\/jcp.24258","article-title":"Mollugin inhibits proliferation and induces apoptosis by suppressing fatty acid synthase in HER2-overexpressing cancer cells","volume":"228","author":"Do","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.bbrc.2014.05.101","article-title":"Mollugin induces tumor cell apoptosis and autophagy via the PI3K\/AKT\/mTOR\/p70S6K and ERK signaling pathways","volume":"450","author":"Zhang","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ejphar.2010.12.027","article-title":"Neuroprotective and anti-inflammatory effects of mollugin via up-regulation of heme oxygenase-1 in mouse hippocampal and microglial cells","volume":"654","author":"Jeong","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejphar.2009.09.008","article-title":"Anti-inflammatory action of mollugin and its synthetic derivatives in HT-29 human colonic epithelial cells is mediated through inhibition of NF-kappa B activation","volume":"622","author":"Kim","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"ref_74","first-page":"620","article-title":"Role of Rubia cordifolia Linn in radiation protection","volume":"45","author":"Tripathi","year":"2007","journal-title":"Indian J. Exp. Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1080\/13880200600798593","article-title":"Antihyperglycemic activity of aqueous root extract of Rubia cordifolia in streptozotocin-induced diabetic rats","volume":"44","author":"Baskar","year":"2006","journal-title":"Pharm. Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jep.2005.08.073","article-title":"Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn","volume":"103","author":"Rao","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/(SICI)1099-1573(199809)12:6<454::AID-PTR331>3.0.CO;2-N","article-title":"Rubia cordifolia extract inhibits cell proliferation in A-431 cells","volume":"12","author":"Tripathi","year":"1998","journal-title":"Phytother. Res."},{"key":"ref_78","first-page":"533","article-title":"Anti-platelet activating factor property of Rubia cordifolia Linn","volume":"31","author":"Tripathi","year":"1993","journal-title":"Indian J. Exp. Biol."},{"key":"ref_79","first-page":"124","article-title":"A comeprehensive review of Rubia cordifolia Linn","volume":"2","author":"Deshkar","year":"2008","journal-title":"Pharmacogn. Rev."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3742\/OPEM.2009.9.1.001","article-title":"Rubia cordifolia: A review","volume":"9","author":"Patil","year":"2009","journal-title":"Orient. Pharm. Exp. Med."},{"key":"ref_81","first-page":"493","article-title":"Comparative study on effects of Rubiae Radix et Rhizoma and carbonized Rubiae Radix et Rhizoma on acute blood stasis rat model","volume":"39","author":"Shan","year":"2014","journal-title":"China J. Chin. Mater. Med."},{"key":"ref_82","first-page":"279","article-title":"Effects of Rubia cordifolia and charred R. Cordifolia on coagulation-fibrinolytic system of normal rats","volume":"19","author":"Geng","year":"2013","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1248\/bpb.33.1430","article-title":"Purpurin as a specific inhibitor of spermidine-induced autoactivation of the protease plasma hyaluronan-binding protein","volume":"33","author":"Nishimura","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.fct.2009.10.019","article-title":"Modulatory role of alizarin from Rubia cordifolia L. against genotoxicity of mutagens","volume":"48","author":"Kaur","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Lee, Y.M., Auh, Q.S., Lee, D.W., Kim, J.Y., Jung, H.J., Lee, S.H., and Kim, E.C. (2013). Involvement of Nrf2-mediated upregulation of hemeoxygenase-1 in mollugin-induced growth inhibition and apoptosis in human oral cancer cells. Biomed. Res. Int.","DOI":"10.1155\/2013\/210604"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1111\/j.2042-7158.2010.01151.x","article-title":"Anti-inflammatory and anticancer compounds isolated from Ventilago madraspatana Gaertn, Rubia cordifolia Linn and Lantana camara Linn","volume":"62","author":"Ghosh","year":"2010","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"250","DOI":"10.4103\/0250-474X.91577","article-title":"Protective effect of hydroalcoholic root extract of Rubia cordifolia in indomethacin-induced enterocolitis in rats","volume":"73","author":"Pawar","year":"2011","journal-title":"Indian J. Pharm. Sci."},{"key":"ref_88","first-page":"2159","article-title":"Protective effect of Rubia cordifolia on reserpine-induced orofacial dyskinesia","volume":"26","author":"Patil","year":"2012","journal-title":"Nat. Prod. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"7884","DOI":"10.1021\/jf0489116","article-title":"Antioxidant phenolic constituents in roots of Rheum officinale and Rubia cordifolia: Structure-radical scavenging activity relationships","volume":"52","author":"Cai","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.fct.2010.01.011","article-title":"Protective effect of the hydro-alcoholic extract of Rubia cordifolia roots against ethylene glycol induced urolithiasis in rats","volume":"48","author":"Divakar","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/ptr.3079","article-title":"Ethyl acetate fraction of the root of Rubia cordifolia L. inhibits keratinocyte proliferation in vitro and promotes keratinocyte differentiation in vivo: Potential application for psoriasis treatment","volume":"24","author":"Lin","year":"2010","journal-title":"Phytother. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4103\/0973-1482.43139","article-title":"Amelioration of cisplatin induced nephrotoxicity in Swiss albino mice by Rubia cordifolia extract","volume":"4","author":"Joy","year":"2008","journal-title":"J. Cancer Res. Ther."},{"key":"ref_93","first-page":"2861","article-title":"Estrogenic and progestational activity of roots of Rubia cordifolia","volume":"19","author":"Parial","year":"2007","journal-title":"Asian J. Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.phymed.2014.10.008","article-title":"Mollugin from Rubia cordifolia suppresses receptor activator of nuclear factor-kappa B ligand-induced osteoclastogenesis and bone resorbing activity in vitro and prevents lipopolysaccharide-induced bone loss in vivo","volume":"22","author":"Baek","year":"2015","journal-title":"Phytomedicine"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1007\/s11418-011-0513-2","article-title":"Anti-HIV activity of Indian medicinal plants","volume":"65","author":"Sabde","year":"2011","journal-title":"J. Nat. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.fct.2009.01.003","article-title":"Possible contribution of rubiadin, a metabolite of madder color, to renal carcinogenesis in rats","volume":"47","author":"Inoue","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1111\/j.1349-7006.2009.01342.x","article-title":"Carcinogenic potential of alizarin and rubiadin, components of madder color, in a rat medium-term multi-organ bioassay","volume":"100","author":"Inoue","year":"2009","journal-title":"Cancer Sci."},{"key":"ref_98","first-page":"35","article-title":"Study on potential toxicity of madder pigment","volume":"40","author":"Li","year":"2013","journal-title":"Guangdong Agric. Sci."},{"key":"ref_99","first-page":"437","article-title":"The pharmacokinetics and leukocytotic effect of 1,4-naphthodiol-2,3-dicarboxylic acid diethyl ester (NDDE)","volume":"32","author":"Wu","year":"1984","journal-title":"Bull. Acad. Mil. Med. Sci."},{"key":"ref_100","first-page":"98","article-title":"Clinical observation of diethylester Rubia cordifolia L. promoting the increase of leucocyte count in leucopenia","volume":"3","author":"Zhang","year":"1983","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"ref_101","first-page":"92","article-title":"Rubidatum","volume":"18","author":"Xie","year":"1987","journal-title":"Pharm. Ind."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1016\/j.bmc.2006.02.036","article-title":"Effects of structural modification on the DNA binding properties and photo-induced cleavagere activity of propargylic sulfones conjugated with an anthraquinone structure","volume":"14","author":"Haruna","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jphotochem.2004.02.014","article-title":"Photosensitisation and photoinduced DNA cleavage by four naturally occurring anthraquinones","volume":"168","author":"Rajendran","year":"2004","journal-title":"J. Photochem. Photobiol. 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