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The isoprenoid-containing 1,1-bisphosphonates exhibited modest antiparasitic activity, whereas the linear \u03b1-fluoro-2-alkyl(amino)ethyl-1,1-bisphosphonates were unexpectedly devoid of antiparasitic activity. In spite of not presenting efficient antiparasitic activity, these data turned out to be very important to establish a structural activity relationship.<\/jats:p>","DOI":"10.3390\/molecules22010082","type":"journal-article","created":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T09:39:32Z","timestamp":1483522772000},"page":"82","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Antiparasitic Activity of Sulfur- and Fluorine-Containing Bisphosphonates against Trypanosomatids and Apicomplexan Parasites"],"prefix":"10.3390","volume":"22","author":[{"given":"Tamila","family":"Galaka","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica and UMYMFOR (CONICET\u2013FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Ferrer Casal","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica and UMYMFOR (CONICET\u2013FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Storey","sequence":"additional","affiliation":[{"name":"Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Chao","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica and UMYMFOR (CONICET\u2013FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Szajnman","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica and UMYMFOR (CONICET\u2013FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4229-8784","authenticated-orcid":false,"given":"Roberto","family":"Docampo","sequence":"additional","affiliation":[{"name":"Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Moreno","sequence":"additional","affiliation":[{"name":"Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5180-096X","authenticated-orcid":false,"given":"Juan","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica and UMYMFOR (CONICET\u2013FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,1,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.actatropica.2009.10.023","article-title":"Specific Chemotherapy of Chagas Disease: Relevance, Current Limitations and New Approaches","volume":"115","author":"Urbina","year":"2010","journal-title":"Acta Trop."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1358\/dof.2010.35.5.1484391","article-title":"New Insights in Chagas Disease Treatment","volume":"35","author":"Urbina","year":"2010","journal-title":"Drugs Future"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2174\/1568005013343191","article-title":"Bisphosphonates as Chemotherapeutic Agents Against Trypanosomatid and Apicomplexan Parasites","volume":"1","author":"Docampo","year":"2001","journal-title":"Curr. 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