{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:49:52Z","timestamp":1792432192568,"version":"4.5.0"},"reference-count":73,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T00:00:00Z","timestamp":1484611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>4-(2-(4-Halophenyl)hydrazinyl)-6-phenylpyridazin-3(2H)-ones 1a,b were prepared and treated with phosphorus oxychloride, phosphorus pentasulphide and ethyl chloroformate to give the corresponding chloropyridazine, pyridazinethione, oxazolopyridazine derivatives 2\u20134, respectively. Compound 2 reacted with hydrazine hydrate to afford hydrazinylpyridazine 7. The reaction of 4-(2-(4-chlorophenyl)hydrazinyl)-3-hydrazinyl-6-phenylpyridazine (7) with acetic anhydride, p-chlorobenzaldehyde and carbon disulphide gave the corresponding pyridazinotriazine derivatives 8\u201310. On the other hand, 5-(4-chlorophenylamino)-7-(3,5-dimethoxybenzylidene)-3-phenyl-5H-pyridazino[3,4-b][1,4]thiazin-6(7H)-one (11) was prepared directly from the reaction of compound 3 with chloroacetic acid in presence of p-chlorobenzaldehyde. Compound 11 reacted with nitrogen nucleophiles (hydroxylamine hydrochloride, hydrazine hydrate) and active methylene group-containing reagents (malononitrile, ethyl cyanoacetate) to afford the corresponding fused compounds 12\u201315, respectively. Pharmacological screening for antiviral activity against hepatitis A virus (HAV) was performed for the new compounds. 4-(4-Chlorophenylamino)-6-phenyl-1,2-dihydropyridazino[4,3-e][1,2,4]triazine-3(4H)-thione (10) showed the highest effect against HAV.<\/jats:p>","DOI":"10.3390\/molecules22010148","type":"journal-article","created":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T10:00:47Z","timestamp":1484733647000},"page":"148","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Synthesis of Some New Pyridazine Derivatives for Anti-HAV Evaluation"],"prefix":"10.3390","volume":"22","author":[{"given":"Eman","family":"Flefel","sequence":"first","affiliation":[{"name":"Department of Chemistry, College of Science, Taibah University, Al-Madinah Al-Monawarah 1343, Saudi Arabia"},{"name":"Department of Photochemistry, Chemical Industries Research Division, National Research Centre, 33 EL-Bohouth St., Dokki 12622, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waled","family":"Tantawy","sequence":"additional","affiliation":[{"name":"Department of Photochemistry, Chemical Industries Research Division, National Research Centre, 33 EL-Bohouth St., Dokki 12622, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8838-6769","authenticated-orcid":false,"given":"Walaa","family":"El-Sofany","sequence":"additional","affiliation":[{"name":"Department of Photochemistry, Chemical Industries Research Division, National Research Centre, 33 EL-Bohouth St., Dokki 12622, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"El-Shahat","sequence":"additional","affiliation":[{"name":"Department of Photochemistry, Chemical Industries Research Division, National Research Centre, 33 EL-Bohouth St., Dokki 12622, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2555-5259","authenticated-orcid":false,"given":"Ahmed","family":"El-Sayed","sequence":"additional","affiliation":[{"name":"Department of Photochemistry, Chemical Industries Research Division, National Research Centre, 33 EL-Bohouth St., Dokki 12622, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Abd-Elshafy","sequence":"additional","affiliation":[{"name":"Department of Water Pollution, Environmental Research Division, National Research Centre, 33 EL-Bohouth St., Dokki 12622, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,1,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ejmech.2016.07.061","article-title":"The therapeutic journey of pyridazinone","volume":"123","author":"Akhtar","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"ref_2","first-page":"1112","article-title":"Exploring potential, synthetic methods and general chemistry of pyridazine and pyridazinone: A brief introduction","volume":"2","author":"Asif","year":"2010","journal-title":"Int. J. ChemTech Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"6624","DOI":"10.1016\/j.bmcl.2010.09.031","article-title":"New pyridazinone derivatives with vasorelaxant and platelet antiaggregatory activities","volume":"20","author":"Costas","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5164","DOI":"10.1016\/j.ejmech.2010.08.029","article-title":"Synthesis and antituberculosis activity of some new pyridazine derivatives. Part II","volume":"45","author":"Mantu","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref_5","first-page":"114","article-title":"The tautomeric properties of 6-(2-pyrrolyl)pyridazin-3-one and 6-(2-pyrrolyl)pyridazin-3-thione","volume":"11","author":"Jones","year":"2007","journal-title":"Arkivoc"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1021\/jm00130a009","article-title":"Synthesis and biological evaluation of substituted benzo[H] cinnolinones and 3H-benzo[6,7]cyclohepta[1,2-c]pyridazinones: Higher homologs of the antihypertensive and antithrombotic 5H-indeno[1,2-c]pyridazinones","volume":"32","author":"Cignarella","year":"1989","journal-title":"J. Med. Chem."},{"key":"ref_7","first-page":"623","article-title":"Cadralazine, a new vasodilator, in addition to a beta-blocker for long-term treatment of hypertension","volume":"35","author":"Salvadeo","year":"1985","journal-title":"Arzneim. Forsch."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/00005344-198105000-00005","article-title":"Pharmacological studies on cadralazine: A new antihypertensive vasodilator drug","volume":"3","author":"Semeraro","year":"1981","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1177\/009286150103500134","article-title":"Evaluation of the characteristics of safety withdrawal of prescription drugs from worldwide pharmaceutical markets-1960 to 1999","volume":"35","author":"Fung","year":"2001","journal-title":"Drug Inf. J."},{"key":"ref_10","first-page":"831","article-title":"Minaprine, a new drug with antidepressant properties","volume":"11","author":"Biziere","year":"1984","journal-title":"Drugs Exp. Clin. Res."},{"key":"ref_11","first-page":"824","article-title":"Pharmacological evaluation of minaprine dihydrochloride, a new psychotropic drug","volume":"32","author":"Biziere","year":"1981","journal-title":"Arzneim. Forsch."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jscs.2010.02.003","article-title":"A study of redox properties of hydralazine hydrochloride, an antihypertensive drug","volume":"14","author":"Imad","year":"2010","journal-title":"J. Saudi Chem. Soc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1056\/NEJM199108013250502","article-title":"A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure","volume":"325","author":"Cohn","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15764\/STAC.2014.01001","article-title":"The pharmacological importance of some diazine containing drug molecules","volume":"1","author":"Asif","year":"2014","journal-title":"Sop Trans. Org. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/j.bmc.2012.12.049","article-title":"Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs","volume":"21","author":"Li","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"593","DOI":"10.2478\/v10007-012-0037-7","article-title":"Heterocyclic compounds based on 3-(4-bromophenyl)azo-5-phenyl-2(3H)-furanone: Anti-avian influenza virus (H5N1) activity","volume":"62","author":"Flefel","year":"2012","journal-title":"Acta Pharm."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejmech.2012.04.020","article-title":"Design, synthesis and antiviral activity of novel pyridazines","volume":"54","author":"Wang","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/10426507.2010.482543","article-title":"Synthesis and Antiviral Activities of \u03b1-Aminophosphonate Derivatives Containing a Pyridazine Moiety","volume":"186","author":"Zhou","year":"2010","journal-title":"Phosphorus Sulfur Silicon Relat. Elem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/jhet.230","article-title":"Synthesis of new pyridazine derivatives as potential anti-HIV-1 agents","volume":"46","author":"Ferro","year":"2009","journal-title":"J. Heterocycl. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1177\/095632020301400402","article-title":"Synthesis and antiviral activities of 3-aralkylthiomethylimidazo[1,2-b]pyridazine derivatives","volume":"14","author":"Galtier","year":"2003","journal-title":"Antivir. Chem. Chemother."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1016\/j.bmc.2012.03.021","article-title":"Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents","volume":"20","author":"Jain","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.bmc.2012.01.033","article-title":"Phosphodiesterase inhibitors. Part 3: Design, synthesis and structure\u2013activity relationships of dual PDE3\/4-inhibitory fused bicyclic heteroaromatic-dihydropyridazinones with anti-inflammatory and bronchodilatory activity","volume":"20","author":"Ochiai","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1007\/s12272-012-1205-5","article-title":"Synthesis and anti-inflammatory activity of novel pyridazine and pyridazinone derivatives as non-ulcerogenic agents","volume":"35","author":"Saeed","year":"2012","journal-title":"Arch. Pharm. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00044-009-9290-9","article-title":"2-Substituted-8-methyl-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazine as an anti-inflammatory agent","volume":"20","author":"Tewari","year":"2011","journal-title":"Med. Chem. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5547","DOI":"10.1016\/j.bmc.2008.04.007","article-title":"Novel anti-inflammatory agents based on pyridazinone scaffold; design, synthesis and in vivo activity","volume":"16","author":"Abouzid","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1007\/s12272-013-0144-0","article-title":"Synthesis and biological evaluation of some novel urea and thiourea derivatives of isoxazolo[4,5-d]pyridazine and structurally related thiazolo[4,5-d]pyridazine as antimicrobial agents","volume":"36","author":"Faidallah","year":"2013","journal-title":"Arch. Pharmacal Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/jccs.201190076","article-title":"Synthesis and Biological Evaluation of New Fused Isoxazolo[4,5-d] Pyridazine Derivatives","volume":"58","author":"Faidallah","year":"2011","journal-title":"J. Chin. Chem. Soc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1080\/10426500500272038","article-title":"Pyridazine Derivatives and Related Compounds, Part 17: The Synthesis of Some 3-Substituted Pyridazino[3\u2032,4\u2032:3,4]pyrazolo[5,1-c]-1,2,4-triazines and Their Antimicrobial Activity","volume":"181","author":"Hosny","year":"2006","journal-title":"Phosphorus Sulfur Silicon Relat. Elem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"7670","DOI":"10.1016\/j.tet.2015.07.063","article-title":"First synthesis of novel 3,3\u2032-bipyridazine derivatives as new potent antihepatocellular carcinoma agents","volume":"71","author":"Yue","year":"2015","journal-title":"Tetrahedron"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"148","DOI":"10.14419\/ijac.v2i2.2661","article-title":"The anticancer potential of various substituted pyridazines and related compounds","volume":"2","author":"Asif","year":"2014","journal-title":"Int. J. Adv. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.ejmech.2014.06.068","article-title":"Design, synthesis and structure\u2013activity relationships of novel 4-phenoxyquinoline derivatives containing pyridazinone moiety as potential antitumor agents","volume":"83","author":"Zhou","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s12272-013-0007-8","article-title":"3-[(6-Arylamino)pyridazinylamino]benzoic acids: Design, synthesis and in vitro evaluation of anticancer activity","volume":"36","author":"Abouzid","year":"2013","journal-title":"Arch. Pharm. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jorganchem.2013.06.040","article-title":"Synthesis, spectroscopy, X-ray analysis and in vitro antiproliferative effect of ferrocenylmethylene-hydrazinylpyridazin-3(2H)-ones and related ferroceno[d]pyridazin-1(2H)-ones","volume":"743","author":"Drahos","year":"2013","journal-title":"J. Organomet. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ejmech.2012.01.026","article-title":"Synthesis and evaluation of anticancer activity of some novel 6-aryl-2-(p-sulfamylphenyl)-pyridazin-3-(2H)-ones","volume":"49","author":"Rathish","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1007\/s00044-011-9851-6","article-title":"Synthesis and preliminary evaluation activity studies of novel 4-(aryl\/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted-piperazine-1-yl)propyl]pyridazin-3(2H)-one derivatives as anticancer agents","volume":"21","author":"Murty","year":"2012","journal-title":"Med. Chem. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5724","DOI":"10.1016\/j.ejmech.2010.09.029","article-title":"Design and synthesis of novel tetrahydro-2H-Pyrano[3,2-c]pyridazin-3(6H)-one derivatives as potential anticancer agents","volume":"45","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s00044-013-0618-0","article-title":"Efficient synthesis, anticonvulsant and muscle relaxant activities of new 2-((5-amino-1,3,4-thiadiazol-2-yl)methyl)-6-phenyl-4,5-dihydropyridazin-3(2H)-one derivatives","volume":"23","author":"Sharma","year":"2014","journal-title":"Med. Chem. Res."},{"key":"ref_38","first-page":"481","article-title":"Anticonvulsant Activity of 4-(Substituted Benzylidene)-6-(3-nitrophenyl)-4, 5-dihydroPyridazin-3(2H)-ones against Maximal Electro Shock Induced Seizure","volume":"9","author":"Asif","year":"2011","journal-title":"Middle-East J. Sci. Res."},{"key":"ref_39","first-page":"522","article-title":"Synthesis and anticonvulsant activity of pyridazinone derivatives","volume":"1","author":"Banerjee","year":"2009","journal-title":"Int. J. ChemTech Res"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0223-5234(02)01405-8","article-title":"Pharmacological evaluation of some new 1-substituted-4-hydroxy-phthalazines","volume":"37","author":"Sivakumar","year":"2002","journal-title":"Eur. J. Med. Chem."},{"key":"ref_41","first-page":"18","article-title":"Analgesic activity of some 6-phenyl-4-substituted benzylidene tetrahydro pyridazin-3(2H)-ones","volume":"5","author":"Asif","year":"2011","journal-title":"Glob. J. Pharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"7397","DOI":"10.1021\/jm900458r","article-title":"Further Studies on Arylpiperazinyl Alkyl Pyridazinones: Discovery of an Exceptionally Potent, Orally Active, Antinociceptive Agent in Thermally Induced Pain","volume":"52","author":"Biancalani","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1007\/s00044-011-9770-6","article-title":"Synthesis and antimycobacterial activities of some new N-acylhydrazone and thiosemicarbazide derivatives of 6-methyl-4,5-dihydropyridazin-3(2H)-one","volume":"21","author":"Tan","year":"2012","journal-title":"Med. Chem. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"778","DOI":"10.4067\/S0717-97072011000300013","article-title":"Synthesis and antitubercular activity of pyridazinone derivatives","volume":"56","author":"Husain","year":"2011","journal-title":"J. Chil. Chem. Soc."},{"key":"ref_45","first-page":"319","article-title":"Synthesis and antitubeculostic activity of 5-{3\u2032-oxo-6\u2032-(substituted phenyl)-2\u2032,3\u2032,4\u2032,5\u2032-tetrahyropyridazin-2\u2032-yl} methyl-2-substituted 1,3,4-oxadiazole","volume":"2","author":"Siddiqui","year":"2010","journal-title":"Der Pharm. Lett."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.bmc.2007.09.031","article-title":"Pyridazinone derivatives: Design, synthesis, and in vitro vasorelaxant activity","volume":"16","author":"Abouzid","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1016\/j.ejmech.2008.12.013","article-title":"Synthesis and blood glucose lowering effect of novel pyridazinone substituted benzenesulfonylurea derivatives","volume":"44","author":"Rathish","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1007\/s00044-015-1490-x","article-title":"Synthesis and antidepressant activity of 5-(benzo[b]furan-2-ylmethyl)-6-methylpyridazin-3(2H)-one derivatives","volume":"25","author":"Boukharsa","year":"2016","journal-title":"Med. Chem. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1021\/jm00123a004","article-title":"3-aminopyridazine derivatives with atypical antidepressant, serotonergic, and dopaminergic activities","volume":"32","author":"Wermuth","year":"1989","journal-title":"J. Med. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.1016\/j.bmcl.2015.05.084","article-title":"Discovery of a novel 2,3,11,11a-tetrahydro-1H-pyrazino[1,2-b]isoquinoline-1,4(6H)-dione series promoting neurogenesis of human neural progenitor cells","volume":"25","author":"Lin","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1021\/jm001088u","article-title":"Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors","volume":"44","author":"Contreras","year":"2001","journal-title":"J. Med. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.1016\/j.bmc.2010.03.066","article-title":"Functionalized pyrazoles and pyrazolo[3,4-d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activity","volume":"18","author":"Biagini","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"5363","DOI":"10.1021\/jm060265+","article-title":"Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase 5 (PDE5) inhibitory activity as potential agents for treatment of erectile dysfunction","volume":"49","author":"Giovannoni","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.bmcl.2010.12.028","article-title":"Triazole incorporated pyridazinones as a new class of antihypertensive agents: Design, synthesis and in vivo screening","volume":"21","author":"Siddiqui","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1007\/s00044-009-9232-6","article-title":"Synthesis of new pyridazinone derivatives as platelet aggregation inhibitors","volume":"19","author":"Thota","year":"2010","journal-title":"Med. Chem. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2478\/v1007-008-0021-4","article-title":"Synthesis and evaluation of 2-substituted-6-phenyl-4,5-dihydropyridazin-3(2H)-ones as potent inodilators","volume":"58","author":"Kumar","year":"2008","journal-title":"Acta Pharm."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1016\/S0968-0896(02)00146-3","article-title":"Pyridazines. Part XXIX: Synthesis and platelet aggregation inhibition activity of 5-substituted-6-phenyl-3(2H)-pyridazinones. Novel aspects of their biological actions","volume":"10","author":"Sotelo","year":"2002","journal-title":"Bioorg. Med. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1021\/jm701474c","article-title":"Biphenyl versus Phenylpyridazine Derivatives: The Role of the Heterocycle in a Series of Acyl-CoA: Cholesterol Acyl Transferase Inhibitors","volume":"51","author":"Gelain","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1021\/acs.orglett.5b00522","article-title":"Synthesis of Peptide Nucleic Acids Containing Pyridazine Derivatives As Cytosine and Thymine Analogs, and Their Duplexes with Complementary Oligodeoxynucleotides","volume":"17","author":"Tomori","year":"2015","journal-title":"Org. Lett."},{"key":"ref_60","unstructured":"Ryan, K.J., and Ray, C.G. (2004). Medical Microbiology: An Introduction to Infectious Diseases, McGraw-Hill."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/S0140-6736(98)01304-X","article-title":"Hepatitis A","volume":"351","author":"Koff","year":"1998","journal-title":"Lancet"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/epirev\/mxj012","article-title":"Hepatitis A in the era of vaccination","volume":"28","author":"Wasley","year":"2006","journal-title":"Epidemiol. Rev."},{"key":"ref_63","first-page":"2971","article-title":"Hepatitis B virus","volume":"4","author":"Hollinger","year":"2001","journal-title":"Fields Virol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/ardp.200600055","article-title":"Synthesis and Biological Evaluation of Some Pyrrolo[2,3-d]pyrimidines","volume":"339","author":"Rashad","year":"2006","journal-title":"Arch. Pharm."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/ardp.200600100","article-title":"Synthesis and Antiviral Evaluation of Some Sugar Arylglycinoylhydrazones and Their Oxadiazoline Derivatives","volume":"339","year":"2006","journal-title":"Arch. Pharm."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1515\/znc-2009-3-402","article-title":"Synthesis and Antiviral Evaluation of 5-(1,2,3-Triazol-1-ylmethyl)uridine Derivatives","volume":"64","author":"Wada","year":"2009","journal-title":"Z. Naturforschung Sect. C J. Biosci."},{"key":"ref_67","first-page":"69","article-title":"New pyrimidine and fused pyrimidine derivatives: Synthesis and anti Hepatitis A virus (HAV) evaluation","volume":"5","author":"Rabie","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/ardp.200700043","article-title":"Conversion of 3-Arylazo-5-phenyl-2(3H)-furanones into Other Heterocycles of Anticipated Biological Activity","volume":"340","author":"Sayed","year":"2007","journal-title":"Arch. Pharm."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1021\/np50064a002","article-title":"Plant Metabolites. Structure and In Vitro Antiviral Activity of Quinovic Acid Glycosides from Uncaria tomentosa and Guettarda platyipoda","volume":"52","author":"Aquino","year":"1989","journal-title":"J. Nat. Prod."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1128\/AAC.39.6.1287","article-title":"Antiviral susceptibility testing with a cell line which expresses beta-galactosidase after infection with herpes simplex virus","volume":"39","author":"Tebas","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1078\/094471103322331467","article-title":"Virucidal effect of peppermint oil on the enveloped viruses herpes simplex virus type 1 and type 2 in vitro","volume":"10","author":"Schuhmacher","year":"2003","journal-title":"Phytomedicine"},{"key":"ref_72","first-page":"556","article-title":"Antiviral activity of tannin from the pericarp of Punica granatum L. against genital Herpes virus in vitro","volume":"20","author":"Zhang","year":"1995","journal-title":"China J. Chin. Mater. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1021\/np50107a013","article-title":"Comparison of the anti-herpes simplex virus activities of propolis and 3-methyl-but-2-enyl caffeate","volume":"57","author":"Amoros","year":"1994","journal-title":"J. Nat. Prod."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/22\/1\/148\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:26:24Z","timestamp":1760207184000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/22\/1\/148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,17]]},"references-count":73,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1]]}},"alternative-id":["molecules22010148"],"URL":"https:\/\/doi.org\/10.3390\/molecules22010148","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,17]]}}}