{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:10:45Z","timestamp":1760267445299,"version":"build-2065373602"},"reference-count":56,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2017,2,19]],"date-time":"2017-02-19T00:00:00Z","timestamp":1487462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Economia y competitividad","doi-asserted-by":"publisher","award":["P116\/C111\/034"],"award-info":[{"award-number":["P116\/C111\/034"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007349","name":"SENACYT","doi-asserted-by":"publisher","award":["151-2016"],"award-info":[{"award-number":["151-2016"]}],"id":[{"id":"10.13039\/501100007349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Twenty-eight neoflavonoids have been prepared and evaluated in vitro against HIV-1. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase reporter gene. Inhibition of HIV transcription and Tat function were tested on cells stably transfected with the HIV-LTR and Tat protein. Seven 4-phenylchromen-2-one derivatives showed HIV transcriptional inhibitory activity but only the phenylchrome-2-one 10 inhibited NF-\u03baB and displayed anti-Tat activity simultaneously. Compounds 10, 14, and 25, inhibited HIV replication in both targets at concentrations &lt;25 \u03bcM. The assays of these synthetic 4-phenylchromen-2-ones may aid in the investigation of some aspects of the anti-HIV activity of such compounds and could serve as a scaffold for designing better anti-HIV compounds, which may lead to a potential anti-HIV therapeutic drug.<\/jats:p>","DOI":"10.3390\/molecules22020321","type":"journal-article","created":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T11:07:24Z","timestamp":1487588844000},"page":"321","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Neoflavonoids as Inhibitors of HIV-1 Replication by Targeting the Tat and NF-\u03baB Pathways"],"prefix":"10.3390","volume":"22","author":[{"given":"Dionisio","family":"Olmedo","sequence":"first","affiliation":[{"name":"Pharmaceutical Chemistry Area, Department of Pharmaceutical Sciences, University of Salamanca, Faculty of Pharmacy, CIETUS, IBSAL, Campus Miguel de Unamuno, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3728-7602","authenticated-orcid":false,"given":"Jos\u00e9","family":"L\u00f3pez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Area, Department of Pharmaceutical Sciences, University of Salamanca, Faculty of Pharmacy, CIETUS, IBSAL, Campus Miguel de Unamuno, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Del Olmo","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Area, Department of Pharmaceutical Sciences, University of Salamanca, Faculty of Pharmacy, CIETUS, IBSAL, Campus Miguel de Unamuno, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6249-6847","authenticated-orcid":false,"given":"Luis","family":"Bedoya","sequence":"additional","affiliation":[{"name":"National Centre of Microbiology, Institute Carlos III, Crt. 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